Clinical Chemistry

Enrichment of Microbial DNA in Plasma to Improve Pathogen Detection in Sepsis: A Pilot Study

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Clin Chem. 2025 Mar 11:hvaf011. doi: 10.1093/clinchem/hvaf011. Online ahead of print. ABSTRACT BACKGROUND: Diagnosis of sepsis and timely identification of pathogens in critically ill patients remains challenging. Plasma metagenomic sequencing to detect microbial cell-free DNA (mDNA) has shown promise, but low abundance of mDNA in plasma limits sensitivity and necessitates high sequencing depth. mDNA is … Read more

Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants by an Improved Full-Length ABO Haplotype Sequencing

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Clin Chem. 2025 Mar 6:hvaf015. doi: 10.1093/clinchem/hvaf015. Online ahead of print. ABSTRACT BACKGROUND: Full-length ABO haplotype sequencing is crucial for accurate genotyping, reference gene annotation, and molecular mechanism analysis of its variants. However, there is currently a deficiency of comprehensive annotation for full-length ABO haplotypes, spanning from the 5′ untranslated region (UTR) to the 3′ … Read more

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