Clinical Chemistry

Enriching Microbial Cell-Free DNA in Clinical Metagenomics Using Epigenetic Filters

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Clin Chem. 2026 Aug 5:hvag089. doi: 10.1093/clinchem/hvag089. Online ahead of print. ABSTRACT INTRODUCTION: Noninvasive cell-free DNA (cfDNA) metagenomic sequencing enables hypothesis-free detection of microbial pathogens in patients with suspected infections. However, its clinical sensitivity is often limited by the overwhelming background of host-derived cfDNA, which can obscure low-abundance microbial signals. We developed an epigenetically guided … Read more

APOB to Estimated APOB Ratio for Screening for the APOE2 Genotype

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Clin Chem. 2026 Aug 3:hvag094. doi: 10.1093/clinchem/hvag094. Online ahead of print. ABSTRACT BACKGROUND: Familial dysbetalipoproteinemia (FDB) is a genetic lipoprotein disorder that can develop in patients homozygous for the apolipoprotein 2 (APOE2) genotype (APOE ɛ2/ɛ2). It is associated with decreased clearance of remnant lipoproteins and increased atherosclerotic cardiovascular disease (ASCVD) risk disproportionate to low-density lipoprotein-cholesterol … Read more

Highly Accurate Sequencing Methods for Low-Frequency Variant Detection

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Clin Chem. 2026 Jul 29:hvag074. doi: 10.1093/clinchem/hvag074. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing (NGS), also known as massively parallel sequencing, has become an essential tool across many areas of the life sciences, yet its application to low-frequency variant detection remains constrained by intrinsic error rates and the high cost of ultra-deep sequencing. To … Read more

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