Association between Glycoprotein Acetylation-Indicated Inflammation and Small HDL Particle Number in Coronary Artery Disease

Clin Chem. 2026 Oct 15:hvag129. doi: 10.1093/clinchem/hvag129. Online ahead of print. ABSTRACT BACKGROUND: Glycoprotein acetylation (GlycA) is a nuclear magnetic resonance-derived biomarker of systemic inflammation. GlycA shows statistical interaction with small HDL particle number (s-HDL-P) in relation to coronary artery disease (CAD). This study examines the confounding effects of GlycA-related glycoproteins, hypertriglyceridemia, and s-HDL-P on … Read more

Optimal Positive Control Assays for Methylation-Specific PCR

Clin Chem. 2026 Sep 1:hvag097. doi: 10.1093/clinchem/hvag097. Online ahead of print. ABSTRACT BACKGROUND: Methylation-specific PCR (MSP) is widely used in cancer diagnostics and requires positive controls to confirm DNA integrity and bisulfite conversion. Positive control assays include conversion-specific PCR (CSP) and cytosine-free fragment (CFF) assays. Despite their ubiquity and critical need in MSP assays, positive … Read more

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