Clinical Chemistry

Poor Performance of LDL-Cholesterol Equations versus Beta Quantification in a Very Large Cohort of Patients with Dyslipidemia

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Clin Chem. 2026 Apr 28:hvag038. doi: 10.1093/clinchem/hvag038. Online ahead of print. ABSTRACT BACKGROUND: Accurate estimations of low-density lipoprotein cholesterol (LDL-C) is important to guide clinical decisions concerning lipid-lowering treatment. The Friedewald formula has been used for the past 50 years, but its limitations compared to the reference β-quantification method have led to the development of … Read more

Saliva vs Plasma in Liquid Biopsy Sampling for Head and Neck Cancer: A Comparative Study

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Clin Chem. 2026 Apr 28:hvag035. doi: 10.1093/clinchem/hvag035. Online ahead of print. ABSTRACT BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) presents significant diagnostic and therapeutic challenges due to its rising incidence and poor prognosis. Liquid biopsy, utilizing biofluids such as blood and saliva, offers a noninvasive approach to detect circulating tumor DNA (ctDNA), circulating tumor … Read more

Novel Rapid Phenotypic Susceptibility Testing Techniques That Enhance Antimicrobial Stewardship and Clinical Decision-Making

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Clin Chem. 2026 Apr 24:hvag033. doi: 10.1093/clinchem/hvag033. Online ahead of print. ABSTRACT BACKGROUND: Antimicrobial resistance (AMR) is a critical global health challenge, underscoring the need for diagnostic innovations that enable timely, and targeted therapy. Rapid phenotypic antimicrobial susceptibility testing (AST) offers a transformative approach by delivering actionable susceptibility results significantly earlier than conventional methods. This … Read more

Transferability and Between Laboratory Imprecision of an LC-MS/MS-Based Reference Measurement Procedure for Apolipoproteins

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Clin Chem. 2026 Apr 18:hvag020. doi: 10.1093/clinchem/hvag020. Online ahead of print. ABSTRACT BACKGROUND: Apolipoprotein standardization in multiple calibration laboratories requires equivalent results to value assign matrix-based reference and external quality assurance materials. A multiplexed LC-MS/MS-based reference measurement procedure (RMP) has been developed for serum apolipoproteins apo(a), apoA-I, apoB, apoC-I, apoC-II, apoC-III, and apoE. This study … Read more

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