Clinical Chemistry

Optimal Positive Control Assays for Methylation-Specific PCR

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Clin Chem. 2026 Sep 1:hvag097. doi: 10.1093/clinchem/hvag097. Online ahead of print. ABSTRACT BACKGROUND: Methylation-specific PCR (MSP) is widely used in cancer diagnostics and requires positive controls to confirm DNA integrity and bisulfite conversion. Positive control assays include conversion-specific PCR (CSP) and cytosine-free fragment (CFF) assays. Despite their ubiquity and critical need in MSP assays, positive … Read more

Clinical Utility and Diagnostic Performance of (1→3)-β-D-Glucan in Invasive Mycoses

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Clin Chem. 2026 Aug 26:hvag108. doi: 10.1093/clinchem/hvag108. Online ahead of print. ABSTRACT BACKGROUND: The BDG assay is a non-culture-based biomarker widely used in the diagnosis of invasive fungal infections, particularly among immunocompromised patients. Conventional diagnostic methods, including culture and histopathology, are limited by low sensitivity and delayed turnaround times, prompting increased reliance on adjunctive serologic … Read more

Genetic Investigation of X-Linked Defects with Optimized Targeted Long-Read Sequencing

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Clin Chem. 2026 Aug 24:hvag088. doi: 10.1093/clinchem/hvag088. Online ahead of print. ABSTRACT BACKGROUND: X-linked genetic diseases affect males and females through different inheritance patterns influenced by sex, where differential methylation caused by X-chromosome inactivation can present with a range of asymptomatic, mild, and severe symptoms in females. Targeted long-read sequencing (LRS) through adaptive sampling (AS) … Read more

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