- Evaluating seven bioinformatics platforms for tertiary analysis of genomic data from whole exome sequencing in a pilot group of patientsNerea Bastida-Lertxundion March 31, 2025 at 10:00 amAdv Lab Med. 2025 Mar 10;6(1):28-36. doi: 10.1515/almed-2025-0031. eCollection 2025 Mar. ABSTRACT OBJECTIVES: To evaluate seven bioinformatics platforms for automated AI-based genomic variant prioritization and classification. METHODS: An evaluation was performed of 24 genetic variants that explained the phenotype of 20 patients. FASTQ files were simultaneously uploaded on the following bioinformatics platforms: Emedgene, eVai, Varsome … Read more
- Parámetros de variabilidad glucémica de la monitorización continua de glucosa como predictores de diabetes: evaluación prospectiva en una población general sin diabetesAndrea Valle Rodríguezon March 31, 2025 at 10:00 amAdv Lab Med. 2025 Jan 13;6(1):52-58. doi: 10.1515/almed-2024-0125. eCollection 2025 Mar. NO ABSTRACT PMID:40160403 | PMC:PMC11949565 | DOI:10.1515/almed-2024-0125
- Evaluating the research parameters available on the Sysmex® XN-series hematology analyzers as markers of dysplasia in peripheral bloodVicente Aguaderoon March 31, 2025 at 10:00 amAdv Lab Med. 2025 Feb 4;6(1):98-102. doi: 10.1515/almed-2025-0003. eCollection 2025 Mar. ABSTRACT OBJECTIVES: Myelodysplastic syndromes (MDS) are clonal hematopoietic disorders characterized by peripheral blood cytopenias, cellular dysplasia and risk for progression into acute leukemia. Recent studies reveal that some research parameters available on Sysmex XN-1000® hematology analyzers, including immature platelet fraction (IPF), Neutrophil Granularity Index … Read more
- Valoración de los parámetros de investigación de los analizadores hematológicos de la serie XN (Sysmex®) como marcadores de displasia en sangre perifèricaVicente Aguaderoon March 31, 2025 at 10:00 amAdv Lab Med. 2024 Dec 2;6(1):103-107. doi: 10.1515/almed-2024-0111. eCollection 2025 Mar. NO ABSTRACT PMID:40160401 | PMC:PMC11949532 | DOI:10.1515/almed-2024-0111
- Parameters of glycemic variability in continuous glucose monitoring as predictors of diabetes: a prospective evaluation in a non-diabetic general populationJavier Rodríguez Garcíaon March 31, 2025 at 10:00 amAdv Lab Med. 2025 Mar 7;6(1):46-51. doi: 10.1515/almed-2025-0011. eCollection 2025 Mar. ABSTRACT OBJECTIVES: To prospectively examine the ability of some glycemic variability metrics from continuous glucose monitoring (CGM) to predict the development of diabetes in a non-diabetic population. METHODS: A total of 497 non-diabetic patients from the AEGIS study were included. Participants used a CGM … Read more
- Luces y sombras de la inteligencia artificial en la medicina de laboratorioGiuseppe Lippion March 31, 2025 at 10:00 amAdv Lab Med. 2025 Mar 3;6(1):4-6. doi: 10.1515/almed-2025-0039. eCollection 2025 Mar. NO ABSTRACT PMID:40160409 | PMC:PMC11949558 | DOI:10.1515/almed-2025-0039
- Intervalos de referencia de parámetros hematológicos en población chilena adulta y en la etnia mapuchePablo J Letelieron March 31, 2025 at 10:00 amAdv Lab Med. 2025 Feb 19;6(1):69-78. doi: 10.1515/almed-2025-0014. eCollection 2025 Mar. NO ABSTRACT PMID:40160408 | PMC:PMC11949563 | DOI:10.1515/almed-2025-0014
- Lights and shadows of artificial intelligence in laboratory medicineGiuseppe Lippion March 31, 2025 at 10:00 amAdv Lab Med. 2025 Feb 24;6(1):1-3. doi: 10.1515/almed-2025-0024. eCollection 2025 Mar. NO ABSTRACT PMID:40160407 | PMC:PMC11949529 | DOI:10.1515/almed-2025-0024
- Evaluation of an alternative centrifugation protocol for reducing total turnaround timeReyes Nicolás de Blason March 31, 2025 at 10:00 amAdv Lab Med. 2024 Nov 21;6(1):108-112. doi: 10.1515/almed-2024-0170. eCollection 2025 Mar. ABSTRACT OBJECTIVES: Centrifugation is a key process that should be controlled to ensure an adequate sample quality. To achieve rapid, standardized, and consistent sample centrifugation, we aimed to evaluate an alternative centrifugation protocol and its impact on the results of 20 biochemical determinations in … Read more
- Reference intervals of hematological parameters in the Chilean adult population and the Mapuche ethnic groupPablo J Letelieron March 31, 2025 at 10:00 amAdv Lab Med. 2025 Jan 3;6(1):59-68. doi: 10.1515/almed-2024-0080. eCollection 2025 Mar. ABSTRACT OBJECTIVES: Reference intervals (RI) are an essential tool to support clinical decisions. These may have intra- and inter-individual variations associated with genetic differences and environmental factors. Given that Chile is a multiethnic territory, studying these variables is even more relevant. The purpose of … Read more
- Sperm recovery from urine in men with retrograde ejaculationErnesto Veiga Álvarezon January 8, 2025 at 11:00 amAdv Lab Med. 2024 Aug 22;5(4):356-365. doi: 10.1515/almed-2024-0109. eCollection 2024 Dec. ABSTRACT INTRODUCTION: Retrograde ejaculation (RE) consists of the reflux backwards, towards the bladder, of the ejaculate, during the emission phase of ejaculation, causing a total or partial absence of sperm emission, with the consequent diversion of semen into the bladder during the emission phase … Read more
- Interference by vitamin B12-macrocomplexes: towards an effective detection and correct interpretation of hypo- and hypervitaminemiaJosé A Delgadoon December 23, 2024 at 11:00 amAdv Lab Med. 2024 Jul 12;5(4):386-393. doi: 10.1515/almed-2024-0041. eCollection 2024 Dec. ABSTRACT OBJECTIVES: The presence of macro-B12 is a cause of factual hypervitaminemia B12. Precipitation with polyethylene glycol (PEG) is a simple method of removing high-molecular-weight biomolecules. However, “free” molecule may co-precipitate. This fact requires the establishment of reference intervals for the post-precipitation result. The … Read more
- Pharmacogenetics of colorectal cancer in a third-level hospital in ValenciaAna Comes-Ragaon December 23, 2024 at 11:00 amAdv Lab Med. 2024 Nov 7;5(4):425-431. doi: 10.1515/almed-2024-0146. eCollection 2024 Dec. ABSTRACT OBJECTIVES: Genetic variants with associated pharmacokinetic and pharmacodynamic effects have an impact on the development of adverse drug reactions and survival of patients with colorectal cancer. METHODS: A selection of genetic variants was performed according to the established chemotherapy and the pharmacogenetic databases. … Read more
- Comparison between a new device for the semen quality analysis and the manual microscopic evaluation in a not specialistic clinical laboratoryErika Janion December 23, 2024 at 11:00 amAdv Lab Med. 2024 Aug 26;5(4):402-406. doi: 10.1515/almed-2024-0089. eCollection 2024 Dec. ABSTRACT OBJECTIVES: Semen analysis investigates different parameters of human semen with a high relevance in fertility workup, confirmation of sterility by post vasectomy, in pathologies follow-up such as varicocele and in all cases where sperm preservation is required. Manually seminal fluid examination is characterized … Read more
- Point of care testing for high-sensitive troponin measurement: experience from a tertiary care hospital clinical laboratorySarra El Amranion December 23, 2024 at 11:00 amAdv Lab Med. 2024 Oct 14;5(4):455-458. doi: 10.1515/almed-2024-0058. eCollection 2024 Dec. NO ABSTRACT PMID:39713542 | PMC:PMC11661533 | DOI:10.1515/almed-2024-0058
- Estudio sobre el valor incremental que supone el informe del sedimento en orina en medicina de urgencias mediante el sistema Sysmex® Serie-UNMarco Tosion December 23, 2024 at 11:00 amAdv Lab Med. 2024 Nov 26;5(4):381-385. doi: 10.1515/almed-2024-0181. eCollection 2024 Dec. ABSTRACT OBJETIVOS: El análisis de orina es ampliamente utilizado y frecuentemente solicitado desde los servicios de urgencias para evaluar la presencia de hipovolemia, infecciones del tracto urinario, diabetes, cetoacidosis y hematuria. Nuestro objetivo era evaluar el impacto de informar el sedimento urinario en muestras … Read more
- Los análisis de orina en el diagnóstico de las gammapatías monoclonales: puntos de corteMònica Vidal-Plaon December 23, 2024 at 11:00 amAdv Lab Med. 2024 Dec 10;5(4):443-446. doi: 10.1515/almed-2024-0184. eCollection 2024 Dec. ABSTRACT OBJETIVOS: Las pruebas de laboratorio resultan cruciales en el diagnóstico de las gammapatías monoclonales. La última actualización de la guía del Grupo Internacional de Trabajo sobre el Mieloma (IMWG) para el diagnóstico de gammapatías monoclonales ha suscitado cierto debate sobre la pertinencia de … Read more
- Falso valor de HbA1c debido a la variante inusual hemoglobina Petie Salpetriere coheredada con talasemia alfaEsperanza Lepe Balsalobreon December 23, 2024 at 11:00 amAdv Lab Med. 2024 Nov 8;5(4):451-454. doi: 10.1515/almed-2024-0143. eCollection 2024 Dec. ABSTRACT OBJETIVOS: Describir la variante de hemoglobina que interfiere en el análisis de HbA1c mediante HPLC de intercambio catiónico. CASO CLÍNICO: Paciente de 78 años que acude a consulta de Medicina Interna para una revisión rutinaria, donde se incluye la determinación de HbA1c para … Read more
- Investigating the incremental value of urine sediment reporting in emergency medicine with a Sysmex UN urinalysis systemMarco Tosion December 23, 2024 at 11:00 amAdv Lab Med. 2024 Jul 12;5(4):377-380. doi: 10.1515/almed-2024-0035. eCollection 2024 Dec. ABSTRACT OBJECTIVES: Urinalysis is widely used and is also frequently requested in emergency situations for screening hypovolemia, urinary tract infections, diabetes, ketoacidosis and hematuria. Our aim was to evaluate the impact of reporting urinary sediment in emergency department specimens with the Sysmex UN system. … Read more
- Impacto de la mutación T315I en el pronóstico de la leucemia mieloide crónicaBushra Kaleemon December 23, 2024 at 11:00 amAdv Lab Med. 2024 Nov 27;5(4):418-424. doi: 10.1515/almed-2024-0172. eCollection 2024 Dec. ABSTRACT OBJETIVOS: Las mutaciones dominio quinasa BCR-ABL1 son una de las principales causas de resistencia a los inhibidores de la tirosina quinasa (ITK) en la leucemia mieloide crónica (LMC), siendo la mutación T315I la más resistente a tratamiento. El objetivo del presente estudio es … Read more