Clin Chem Lab Med. 2026 Sep 23. doi: 10.1515/cclm-2026-1304. Online ahead of print. ABSTRACT OBJECTIVES: Serum total homocysteine (tHcy) is interpreted against fixed reference intervals and a decision limit. Whether the month of blood collection is a material source of variation, and whether it reflects the seasonal cycle of 25-hydroxyvitamin D [25(OH)D], is unresolved because … Read more
Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1063. Online ahead of print. ABSTRACT OBJECTIVES: Anti-thyroglobulin antibodies (TgAb) have a dual role during the follow-up of differentiated thyroid cancer (DTC): they may interfere with thyroglobulin (Tg) immunoassays and also serve as surrogate biomarkers of disease status. However, laboratory practices for TgAb measurement and reporting remain … Read more
Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1371. Online ahead of print. ABSTRACT Laboratory specialists have been assigned responsibility for algorithmically assisted reporting without an operational definition of what responsible oversight means. Results pass largely through rule-based approval systems, and increasingly through probabilistic models, yet the obligation attached to the specialist’s name on the … Read more
Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1439. Online ahead of print. ABSTRACT The European Union Safe Hearts Plan provides an opportunity to strengthen cardiovascular prevention, early detection, treatment, and monitoring across Europe. This EFLM position paper argues that laboratory medicine must be recognized as a central component of its implementation. Reliable and harmonized … Read more
Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1332. Online ahead of print. ABSTRACT The global harmonization of measurements in laboratory medicine is facilitated by the development and implementation of reference measurement systems, including suitable certified reference materials (CRMs). There are, however, a relatively small number of CRM producers worldwide. In the context of limited … Read more
Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1265. Online ahead of print. ABSTRACT INTRODUCTION: Morphologic examination of peripheral blood and bone marrow remains central to the diagnosis and classification of hematologic disorders. Conventional optical microscopy, however, is labor-intensive, dependent on operator expertise, and affected by interobserver variability. Digital morphology has developed from automated image … Read more
Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1377. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine has begun to describe its own future, and the images it produces are almost uniformly expansionary. What they rarely contain is a collapse scenario: a future in which the field delivers less than today. A profession planning for … Read more
Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0510. Online ahead of print. ABSTRACT OBJECTIVES: Ceruloplasmin (Cp) and non-ceruloplasmin-bound copper (NCC) are measured when evaluating liver disease and disorders of copper (Cu) metabolism. Cp mass concentration is typically determined by immunoassays that detect both apo- and holoceruloplasmin. In contrast, enzymatic assays measure Cp ferroxidase activity … Read more
Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0319. Online ahead of print. ABSTRACT To ensure reported laboratory results are of adequate quality, it is paramount that the set analytical performance specifications (APS) are tailored to the intended uses of the measurand. For measurands with a pivotal position in the clinical pathway, APS should be … Read more
Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0687. Online ahead of print. ABSTRACT OBJECTIVES: Calculated low-density lipoprotein cholesterol (LDL-C) is widely reported, but formula-dependent estimation differences may alter classification near decision thresholds. We assessed formula-dependent LDL-C classification relative to direct LDL-C in UK Biobank and examined cardiovascular outcomes descriptively. METHODS: We analyzed 397,490 participants … Read more
Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0885. Online ahead of print. ABSTRACT OBJECTIVES: Urinary tract infections (UTIs) are very common in clinical practice. Urine culture remains the cornerstone of UTI diagnosis, but urinalysis screening for bacteriuria can improve workflow. The aim of the study was to screen for significant bacteriuria using Aution Eye … Read more
Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-1057. Online ahead of print. ABSTRACT OBJECTIVES: Current guidelines advise calcitonin measurements in washout from fine needle aspiration cytology (FNAC) upon inconclusive cytological examination of medullary thyroid cancer (MTC). (Pre-)analytical validation studies of calcitonin measurements in FNAC washout are however missing. In this study, we examined (pre-)analytical … Read more
Clin Chem Lab Med. 2026 Sep 9. doi: 10.1515/cclm-2026-0604. Online ahead of print. ABSTRACT The main characteristic of point-of-care testing (PoCT) is to provide rapid test results. It remains uncertain whether faster PoCT results truly improve patient management in the emergency department (ED), and how robust the supporting evidence is. This systematic review aimed to … Read more
Clin Chem Lab Med. 2026 Sep 7. doi: 10.1515/cclm-2026-0887. Online ahead of print. ABSTRACT The boom of generative artificial intelligence (AI) is empowering laboratory medicine specialists to create clinical software through conversational prompts without formal programming training, a practice referred to as “vibe coding”. Although vibe coding provides unprecedented potential to address workflow inefficiencies, it … Read more
Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1100. Online ahead of print. ABSTRACT OBJECTIVES: Clinical interpretation of ferritin is hindered by between-assay differences, persisting despite the introduction of different generations of WHO standard. To aid harmonisation efforts, this study investigates the commutability of External Quality Assessment (EQA) materials, proof-of-concept reference materials (cRMs), and the … Read more
Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-0893. Online ahead of print. ABSTRACT OBJECTIVES: Accurate quantification of M-proteins is important for clinical management of monoclonal gammopathies. Reliable assessment of trueness on M-protein quantification in External Quality Assessment (EQA) schemes is difficult due to the lack of reference methods and materials for target value assignment. … Read more
Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1099. Online ahead of print. ABSTRACT OBJECTIVES: Using HbA1c for diabetes diagnosis directly links analytical uncertainty to patient classification. Since traditional performance metrics provide limited insight into these clinical implications, we developed a probabilistic framework to translate HbA1c concentrations and components of analytical uncertainty into clinically interpretable … Read more
Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-0910. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine relies on multiple metrological, analytical, interpretative, and clinical frameworks. Although each addresses a specific question, the relationships linking measurement, interpretation, clinical translation, and action remain incompletely articulated. This fragmentation may encourage inferential overreach, whereby evidence is used to … Read more
Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1113. Online ahead of print. ABSTRACT Cerebrospinal fluid biomarkers, and more recently blood-based biomarkers, are playing a pivotal role in reshaping the clinical management of neurodegenerative diseases, supporting early detection, biological diagnosis, patient stratification, prognostic assessment, therapeutic decision-making, and longitudinal disease monitoring. To effectively support clinical decision-making, … Read more
Clin Chem Lab Med. 2026 Sep 3. doi: 10.1515/cclm-2026-1262. Online ahead of print. ABSTRACT Lipoprotein(a) [Lp(a)] is a causal, independent risk factor for atherosclerotic cardiovascular disease and calcific aortic valve stenosis. New guidelines recommend testing everyone at least once in a lifetime, and with new drugs specifically targeting Lp(a) on the horizon, accurate measurement remains … Read more
Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0427. Online ahead of print. ABSTRACT OBJECTIVES: Piperacillin is a broad-spectrum antibiotic used to treat critically ill patients with severe infections, requiring therapeutic drug monitoring (TDM). We report the development of an isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure (RMP) to quantify piperacillin in human … Read more
Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0333. Online ahead of print. ABSTRACT OBJECTIVES: In vitro serum potassium is affected by ambient temperature with peaks in the winter and troughs in the summer. We investigated whether primary care phlebotomy locations with higher winter hyperkalaemia rates exhibited higher summer hypokalaemia and evaluated a simple screening … Read more
Clin Chem Lab Med. 2026 Sep 1. doi: 10.1515/cclm-2026-0865. Online ahead of print. ABSTRACT OBJECTIVES: To compare 24-h urinary excretion of aldosterone (24-h UEA) measured by competitive chemiluminescent immunoassay (cCLIA) and sandwich chemiluminescent immunoassay (sCLIA) with liquid chromatography-tandem mass spectrometry (LC-MS/MS), and to evaluate a direct renin concentration (DRC)-stratified interpretive strategy for primary aldosteronism (PA). … Read more
Clin Chem Lab Med. 2026 Aug 28. doi: 10.1515/cclm-2026-1235. Online ahead of print. ABSTRACT Clostebol is an anabolic androgenic steroid prohibited at all times (class S1.1) by the World Anti-Doping Agency. In several countries, however, clostebol acetate is available without prescription in topical medicinal products, particularly Trofodermin®, creating a substantial risk of inadvertent exposure. Experimental … Read more
Clin Chem Lab Med. 2026 Aug 27. doi: 10.1515/cclm-2026-1271. Online ahead of print. ABSTRACT OBJECTIVES: To develop and apply an operational framework integrating metrological, analytical, clinical and risk evidence to authorise an output-specific reporting rule after a change in measurement procedure. METHODS: Four measurement procedure changes were evaluated: alanine aminotransferase (ALT) procedures with and without … Read more
Clin Chem Lab Med. 2026 Aug 26. doi: 10.1515/cclm-2026-1075. Online ahead of print. ABSTRACT INTRODUCTION: Hepatitis B virus (HBV) infection remains a major global public health problem. Dried blood spot (DBS) sampling is simple to collect, stable during transport, and easy to store, and may therefore provide an alternative sampling strategy for decentralized HBV testing. … Read more
Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1215. Online ahead of print. ABSTRACT Albumin measurements in serum have important diagnostic and prognostic roles. However, non-standardized measurement procedures are still used in medical laboratories. An agreed approach for the implementation of metrological traceability to the International System of Units (SI) of serum albumin measurements is … Read more
Clin Chem Lab Med. 2026 Aug 24. doi: 10.1515/cclm-2026-1125. Online ahead of print. ABSTRACT Hospital-acquired anemia is highly prevalent and largely preventable complication of hospitalization, affecting up to 40-74 % of patients and up to 90 % of intensive care units patients. Excessive diagnostic blood loss from routine phlebotomy represents a significant and modifiable contributor, … Read more
Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0944. Online ahead of print. ABSTRACT OBJECTIVES: Serum neurofilament light chain (sNfL) reflects neuroaxonal injury in relapsing-remitting multiple sclerosis (RRMS), but its clinical utility is limited by high interindividual variability and confounders such as renal function. Population-based thresholds may therefore be suboptimal for longitudinal monitoring. The reference … Read more
Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0783. Online ahead of print. ABSTRACT OBJECTIVES: Thalassemia and hemoglobinopathies are significant genetic disorders in Thailand. Routine diagnostic methods including complete blood count (CBC), hemoglobin (Hb) analysis, and targeted PCR, are effective for detecting common mutations but limited sensitivity for rare and unstable variants, and complex genotypes. … Read more
Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0870. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPL) are essential biomarkers for classification, diagnosis, and risk stratification of antiphospholipid syndrome (APS). Although automated analytical platforms, such as chemiluminescent immunoassay (CLIA), and particle-based multi-analyte technology (PMAT), are increasingly implemented in routine laboratories, uncertainty remains regarding their … Read more
Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0836. Online ahead of print. ABSTRACT OBJECTIVES: Preanalytical errors account for approximately 60-70 % of all laboratory errors, with sample misidentification among the most frequent causes of inaccurate and unreliable test results. Pre-barcoded tubes (PBTs) are collection tubes uniquely identified during manufacturing with machine-readable labels, eliminating the … Read more
Clin Chem Lab Med. 2026 Aug 19. doi: 10.1515/cclm-2026-0593. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of gentamicin is critical to ensure efficacy and minimize toxicity. We report a candidate reference measurement procedure (RMP) to quantify gentamicin in biological matrices, establishing an unbroken traceability chain to the International System of Units (SI). … Read more
Clin Chem Lab Med. 2026 Aug 18. doi: 10.1515/cclm-2026-1024. Online ahead of print. ABSTRACT The main purpose of establishing APS is to ensure that test performance aligns with their specific clinical goals. Analytical performance specifications serve multiple functions: as acceptance criteria to verify that in vitro diagnostic medical devices (IVD MD) meet regulatory and quality … Read more
Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0410. Online ahead of print. ABSTRACT OBJECTIVES: 24 hour urine free cortisol measurement is widely used for screening Cushing’s syndrome, but its reliability is limited by variability due to inherent biological variation and variation introduced by collection errors. This study aimed to determine the proportion of inaccurately … Read more
Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0950. Online ahead of print. ABSTRACT Lipoprotein X (LpX) is an abnormal lipoprotein-like particle occurring mainly in cholestasis, lecithin-cholesterol acyltransferase deficiency, post-transplant cholestatic liver dysfunction, hepatic graft-versus-host disease, and selected intravenous lipid emulsion or parenteral nutrition settings. Enrichment in phospholipids and unesterified cholesterol, paucity of cholesteryl esters … Read more
Clin Chem Lab Med. 2026 Aug 12. doi: 10.1515/cclm-2026-0509. Online ahead of print. ABSTRACT OBJECTIVES: Vancomycin is a glycopeptide antibiotic used to treat severe Gram-positive infections; its narrow therapeutic window makes therapeutic drug monitoring (TDM) critical. We report the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) candidate reference measurement procedure (RMP) to quantify vancomycin … Read more
Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0844. Online ahead of print. ABSTRACT OBJECTIVES: Serum M-protein analysis is central to the assessment of monoclonal gammopathies. Quantitation and isotyping are commonly performed by SPE or CZE and IFE or IT, respectively. While these assays are widely used, they are characterized by limited sensitivity and subjective … Read more
Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0777. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic monoclonal antibodies (t-mAbs) are increasingly used in oncology, hematology, autoimmune diseases, and inflammatory disorders. Because most of these agents are monoclonal immunoglobulins, they may be detected by serum immunofixation electrophoresis (IFE) and mimic pathological monoclonal proteins. METHODS: We analyzed … Read more
Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0941. Online ahead of print. ABSTRACT OBJECTIVES: Bone status indices (BSIs) are increasingly used in metabolic bone disease, yet global laboratory practices remain poorly characterized. Building on recent IOF-IFCC nomenclature and ESCEO-IOF-IFCC recommendations, we conducted an international descriptive survey of BSI practices. METHODS: A cross-sectional web-based questionnaire … Read more
Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0817. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratories face growing demands to balance healthcare needs with cost and resource efficiency. Solutions that optimise space, cut costs, and minimise water use and waste offer a competitive edge. This study compares water consumption, waste generation, and reagent efficiency … Read more
Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0949. Online ahead of print. ABSTRACT Integrated diagnostics is an emerging multidisciplinary model of care that integrates traditionally siloed domains, including pathology, radiology, genomics, and laboratory medicine, into a coordinated framework designed to improve diagnostic accuracy, treatment selection, and clinical outcomes. In this position statement, the EFLM … Read more
Clin Chem Lab Med. 2026 Aug 6. doi: 10.1515/cclm-2026-0428. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of meropenem is critical for optimizing clinical efficacy and minimizing toxicity. We describe the validation of an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) candidate reference measurement procedure (RMP) for the quantification of meropenem in human serum … Read more
Clin Chem Lab Med. 2026 Aug 4. doi: 10.1515/cclm-2026-0711. Online ahead of print. ABSTRACT OBJECTIVES: Limited guidance on the use and interpretation of cardiac troponin (cTn) testing in pediatric populations has restricted its broader adoption, despite the significant burden of congenital and acquired cardiac conditions in children. This survey aimed to evaluate global availability, utilization … Read more
Clin Chem Lab Med. 2026 Aug 3. doi: 10.1515/cclm-2026-0609. Online ahead of print. ABSTRACT OBJECTIVES: Pregnancy involves dynamic metabolic changes that cannot be accurately interpreted using population reference intervals (RI). The aim was to develop continuous reference curves for common hematology and biochemistry laboratory analytes in pregnancy and to assess their agreement with the RIs … Read more
Clin Chem Lab Med. 2026 Jul 30. doi: 10.1515/cclm-2026-0536. Online ahead of print. ABSTRACT Population screening for type 1 diabetes (T1D) using pancreatic islet autoantibodies is increasingly recognized as a promising strategy to reduce diabetic ketoacidosis and identify individuals during the presymptomatic stages of the disease. In Italy, Law 130/2023 and the implementing decree of … Read more
Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0875. Online ahead of print. ABSTRACT BACKGROUND: Patient risk management has become central to clinical laboratory quality standards, including the Clinical and Laboratory Standards Institute (CLSI) EP23 2nd edition (CLSI EP23-ED2), International Organization for Standardization (ISO) 15189:2022, ISO 22367:2026, and ISO 14971:2019. A key component of risk … Read more
Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0469. Online ahead of print. ABSTRACT OBJECTIVES: Traditional urine immunofixation electrophoresis (uIFE) is cumbersome, has limited sensitivity, and is subjectively interpreted. This is especially problematic in renal impairment where accumulation of polyclonal free light chains may pseudonormalize the serum free light chain (sFLC) ratio, compromising its reliability … Read more
Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0815. Online ahead of print. ABSTRACT OBJECTIVES: External quality assessment (EQA) is essential for ensuring reliable biochemical genetic testing. This study evaluated long-term performance trends in ERNDIM quantitative EQA schemes, including special assays in serum (SAS), special assays in urine (SAU), purines and pyrimidines in urine (PPU), … Read more
Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0185. Online ahead of print. ABSTRACT OBJECTIVES: Colorectal cancer (CRC) screening is crucial for early detection, yet the invasiveness of the gold-standard colonoscopy limits compliance. To address the limitation, this study proposes a novel multi-target free DNA methylation model and evaluated its risk stratification performance for CRC … Read more
Clin Chem Lab Med. 2026 Jul 28. doi: 10.1515/cclm-2026-0570. Online ahead of print. ABSTRACT OBJECTIVES: Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Emerging lung cancer screening in smokers may offer an opportunity for simultaneous cardiovascular risk evaluation. We developed a mobile CT screening unit and assessed the feasibility of integrating dyslipidemia screening … Read more
Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0864. Online ahead of print. ABSTRACT INTRODUCTION: To analyse the structural and operational divergences between NF EN ISO 15189:2022 and Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR) in the context of medical laboratory practice in Europe. CONTENT: This article provides a structured comparative analysis … Read more
Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0790. Online ahead of print. ABSTRACT OBJECTIVES: Understanding whether the novel long-T ITC complex might assist in interpreting clinical prognostic utility compared to established cardiac biomarkers is needed. We determined long term major adverse cardiac events (MACE) and all-cause mortality (ACM) predicated on novel long-T ITC complex … Read more
Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0863. Online ahead of print. ABSTRACT OBJECTIVES: Biological variation (BV) data are essential for many purposes in laboratory medicine, however, the complex statistical analysis remains a barrier for delivery of BV data. This study describes the development of a web-based BV Calculator based on the Biological Variation … Read more
Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0627. Online ahead of print. ABSTRACT OBJECTIVES: Accurate interpretation of pediatric laboratory test results requires robust age- and sex-specific reference intervals (RIs). Undertaking studies to establish RIs across the pediatric age range is particularly challenging due to rapid physiological changes during growth and development. While the Roche … Read more
Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0903. Online ahead of print. ABSTRACT Laboratory medicine is undergoing a profound transformation driven by advances in artificial intelligence (AI), automation, and data interoperability. By 2050, laboratories may evolve from analytical testing facilities into an interconnected health intelligence capable of translating biological, digital, and environmental data into … Read more
Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0704. Online ahead of print. ABSTRACT OBJECTIVES: Most available data on human chorionic gonadotropin (hCG) elevations in menopausal women are derived from studies using Roche assays, with limited evidence across other immunoassay platforms. This study aimed to establish assay-specific reference values for hCG and evaluate the impact … Read more
Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0866. Online ahead of print. ABSTRACT OBJECTIVES: Urinalysis is essential for detecting kidney disease, urinary tract infections, and diabetes mellitus. Point-of-care testing enables rapid screening in decentralized settings and supports low-throughput laboratories. This study evaluated the Sysmex UC-1000 according to the 2023 EFLM urinalysis guidelines in a … Read more
Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0358. Online ahead of print. ABSTRACT OBJECTIVES: Launched in 2012, the Choosing Wisely initiative promotes evidence-based recommendations to reduce unnecessary tests and treatments. This study reviewed laboratory-related recommendations from five countries (USA, UK, Germany, Switzerland, and Austria) to assess their scientific validity. METHODS: Choosing Wisely websites were … Read more
Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0380. Online ahead of print. ABSTRACT INTRODUCTION: The identification of early biomarkers is a critical prerequisite for the development and optimization of preventive strategies targeting preterm prelabour rupture of membranes (pPROM). The aim of this systematic review was to evaluate first trimester serum biomarkers for predicting the … Read more
Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0201. Online ahead of print. ABSTRACT OBJECTIVES: Practical implementation of patient-based real-time quality control (PBRTQC) requires analyte- and institution-specific optimization. This study evaluated the operational feasibility of average-of-normals (AoN)-based PBRTQC through a structured selection process and prospective event-based validation. METHODS: PBRTQC monitoring was performed using the Average … Read more
Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0511. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to establish a comprehensive panel of dried blood spot (DBS)-specific reference intervals (RIs) for vitamins, essential elements, and potentially toxic elements (PTEs) in Chinese adults, and to introduce a hierarchical decision framework for selecting between healthy- and … Read more
Clin Chem Lab Med. 2026 Jul 15. doi: 10.1515/cclm-2026-0671. Online ahead of print. ABSTRACT OBJECTIVES: Capillary blood sampling enables minimally invasive testing and decentralized workflows, but interchangeability with venous specimens may depend on collection site, device, and matrix. METHODS: We conducted a single-center, paired clinical study of 480 adults yielding 960 capillary specimens (fingertip lancet … Read more
