The frequency of JAK2 V617F mutation and its association with low EPO levels in polycythemia vera patientsRecai Aci Adem Keskin Özlem Sezer Taner Karakaya Samet Semiz Halit Kızılet a Söke Vocational School of Health Services, Aydın Adnan Menderes University, Aydın, Turkeyb Department of Medical Biochemistry, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Turkeyc Department of Internal Medicine, Department of Medical Genetics, Samsun University Faculty of Medicine, Samsun, Turkeyd Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkeyon May 8, 2025 at 9:37 am May 9, 2025 .
Platelet indices at admission and their performance associated with predicting all-cause mortality in the ICU: a large cross-sectional cohort studyUsman Ali Department of Haematology, The Royal London Hospital, London, UKon May 4, 2025 at 5:59 am May 6, 2025 .
Performance assessment of ChatGPT in classification of urine particlesLaura Pighi Davide Negrini Marco Tosi Giuseppe Lippi Section of Clinical Biochemistry, University of Verona, Verona, Italyon April 21, 2025 at 11:36 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 223-227.
Converting waste into value. Stability of leftover EDTA whole blood: serum vs. plasma for nine clinical chemistry analysesCindhya Sithiravel Tor A. Strand Ingunn Tjelde Fauskrud Ine Kathrine Granberg Hege K. Tjølsen Hermansen Ragnhild Røysland Kjersti S. Bakken a Multidisciplinary Laboratory Medicine and Medical Biochemistry, Akershus University Hospital, Lørenskog, Norwayb Department of Research, Innlandet Hospital Trust, Lillehammer, Norwayc Center for International Health, University of Bergen, Bergen, Norwayd Department of Microbiology, Innlandet Hospital Trust, Lillehammer, Norwaye Institute of Clinical Medicine, University of Oslo, Oslo, Norwayf Women’s Clinic, Innlandet Hospital Trust, Lillehammer, Norwayon April 20, 2025 at 6:22 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 214-219.
Stability of 17 endocrine analytes in serum or plasma after four cycles of repeated freezing and thawingElisabet Tjernvoll Arne Åsberg Ingrid Alsos Lian Lena Løfblad Gunhild Garmo Hov Ketil Thorstensen Gustav Mikkelsen a Department of Clinical Chemistry, Trondheim University Hospital, Trondheim, Norwayb Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norwayon April 17, 2025 at 12:34 pm May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 190-195.
Evaluation of hemolysis as a source of interference in the determination of S-100B using the LIAISON® S100 assayJaime I. Sainz de Medrano Judit Julian Irene Martínez Anna Escalante Helena Castellà Victoria Ortiz Esther Fernández-Galán Javier Laguna a Department of Biochemistry and Molecular Genetics, CDB, Hospital Clínic, Barcelona, Spainb CORE Laboratory, CDB, Hospital Clínic, Barcelona, Spainc Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spainon April 11, 2025 at 6:36 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 220-222.
The effect of common blood sampling types on metabolic screeningCeylan Bal Esra Özyurt Gülsen Yılmaz a Department of Biochemistry, Ankara Yıldırım Beyazıt University, Ankara, Turkeyb Department of Biochemistry, Ankara City Hospital, Ankara, Turkeyon April 10, 2025 at 6:03 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 196-201.
Exploratory method comparison analysis with emphasis on graphical illustrationsBent Kristensen Marc Ø. Nielsen Arlinda Ljoki Bo Zerahn Lars T. Jensen Department of Nuclear Medicine, Herlev University Hospital, Herlev, Denmarkon April 23, 2025 at 10:08 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 202-213.
Evaluation of measurement uncertainty in direct and estimated serum osmolality according to ISO/TS 20914: implications for clinical diagnosticsMehmet Fatih Alpdemir Sezen Tutar Medine Alpdemir a Medical Biochemistry, Ministry of Health Ankara Bilkent City Hospital, Ankara, Turkeyb Medical Biochemistry, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkeyon April 4, 2025 at 4:29 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 184-189.
Cold activation in PT-INR samples – Myth or reality in the modern laboratory?Annika Petersson Karin Strandberg Magnus Magnusson Jenny Lerman Kim Ekblom a Department of Clinical Chemistry and Transfusion Medicine, Växjö Central Hospital, Växjö, Swedenb Department of Translational Medicine, Lund University, Lund, Swedenc Department of Clinical Chemistry and Pharmacology, Division of Laboratory Medicine, Coagulation Laboratory, University and Regional Laboratories Region Skåne, Malmö, Swedend Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Swedene Department of Research and Development, Region Kronoberg, Växjö, Swedenon April 4, 2025 at 12:51 pm May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 175-179.
The effects of storage conditions on the stability of salivary melatonin in synthetic fiber swabs for home samplingJennifer Anton Charlotte S. Larsen Majken Gudmundsson Lasse K. Bak a Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Denmarkb Translational Research Center (TRACE), Copenhagen University Hospital, Rigshospitalet, Denmarkc Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmarkon April 10, 2025 at 2:38 am May 6, 2025 Volume 85, Issue 3, MAY 2025, Page 180-183.
Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors May 5, 2025 Clin Chem. 2025 May 5:hvaf045. doi: 10.1093/clinchem/hvaf045. Online ahead of print. ABSTRACT BACKGROUND: Existing circulating cell-free DNA (cfDNA) assays are primarily centralized, requiring specialized sample handling and transportation. Implementing a …
Read more Detecting cardiac injury: the next generation of high-sensitivity cardiac troponins improving diagnostic outcomesGiuseppe Lippion May 4, 2025 at 10:00 am May 4, 2025 Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0418. Online ahead of print. ABSTRACT Cardiac injury, encompassing a spectrum of heart muscle damage, requires prompt and accurate diagnosis to improve …
Read more A value-based score for clinical laboratories: promoting the work of the new EFLM committeeMario Plebanion May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0490. Online ahead of print. ABSTRACT After the dissemination of a manifesto for the implementation of value-based laboratory medicine (VBLM) and a …
Read more Autoverified Chocolate-Colored Plasma Samples May 2, 2025 Clin Chem. 2025 May 2;71(5):612-613. doi: 10.1093/clinchem/hvaf026. NO ABSTRACT PMID:40314564 | DOI:10.1093/clinchem/hvaf026
Commentary on Secondary Amenorrhea and Clinical Hyperandrogenism in a 34-Year-Old Female: Polycystic Ovary Syndrome or Not? May 2, 2025 Clin Chem. 2025 May 2;71(5):547. doi: 10.1093/clinchem/hvaf006. NO ABSTRACT PMID:40314563 | DOI:10.1093/clinchem/hvaf006
Commentary on Secondary Amenorrhea and Clinical Hyperandrogenism in a 34-Year-Old Female: Polycystic Ovary Syndrome or Not? May 2, 2025 Clin Chem. 2025 May 2;71(5):546. doi: 10.1093/clinchem/hvae224. NO ABSTRACT PMID:40314562 | DOI:10.1093/clinchem/hvae224
Secondary Amenorrhea and Clinical Hyperandrogenism in a 34-Year-Old Female: Polycystic Ovary Syndrome or Not? May 2, 2025 Clin Chem. 2025 May 2;71(5):542-545. doi: 10.1093/clinchem/hvae214. NO ABSTRACT PMID:40314561 | DOI:10.1093/clinchem/hvae214
Biological Variation of Erythrocyte Total, Metal-Free, and Zinc Protoporphyrin IX in Patients with Erythropoietic Protoporphyria and Healthy Subjects: Implications for Clinical Interpretation and Monitoring May 2, 2025 Clin Chem. 2025 May 2:hvaf055. doi: 10.1093/clinchem/hvaf055. Online ahead of print. ABSTRACT BACKGROUND: There is a lack of robust biological variation (BV) data for porphyria-related biomarkers. Our study aimed to …
Read more Red Blood Cell-Bound Cell-Free DNA Is an Insensitive Marker for Diagnosis of Bacterial Infections May 2, 2025 Clin Chem. 2025 May 2:hvaf053. doi: 10.1093/clinchem/hvaf053. Online ahead of print. NO ABSTRACT PMID:40314285 | DOI:10.1093/clinchem/hvaf053
Laboratory Information Systems and globalization of NPUon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s1830-s1835. doi: 10.1515/cclm-2025-8055. Print 2025 May 26. NO ABSTRACT PMID:40314545 | DOI:10.1515/cclm-2025-8055
ROUND-TABLE 2 – Health Economics: Transforming Laboratory Data into Valueon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s53-s56. doi: 10.1515/cclm-2025-8023. Print 2025 May 26. NO ABSTRACT PMID:40314544 | DOI:10.1515/cclm-2025-8023
PLENARY LECTURE 2 – Sepsis associated acute kidney injuryon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s9. doi: 10.1515/cclm-2025-8006. Print 2025 May 26. NO ABSTRACT PMID:40314543 | DOI:10.1515/cclm-2025-8006
Toxicology and TDMon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s2643-s2727. doi: 10.1515/cclm-2025-8071. Print 2025 May 26. NO ABSTRACT PMID:40314542 | DOI:10.1515/cclm-2025-8071
PLENARY LECTURE 4 – Digital Twins: from Personalised Medicine to Precision Public Healthon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s11. doi: 10.1515/cclm-2025-8008. Print 2025 May 26. NO ABSTRACT PMID:40314541 | DOI:10.1515/cclm-2025-8008
Hematology and hemostasison May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s1362-s1581. doi: 10.1515/cclm-2025-8051. Print 2025 May 26. NO ABSTRACT PMID:40314550 | DOI:10.1515/cclm-2025-8051
SYMPOSIUM 6 – Environmental Impact of Laboratory Medicine (Green and Sustainable Medical Laboratories)on May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s51-s52. doi: 10.1515/cclm-2025-8022. Print 2025 May 26. NO ABSTRACT PMID:40314549 | DOI:10.1515/cclm-2025-8022
SYMPOSIUM 4 – Defining analytical performance requirements for laboratory tests to make them fit for clinical purposeon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s45-s47. doi: 10.1515/cclm-2025-8020. Print 2025 May 26. NO ABSTRACT PMID:40314548 | DOI:10.1515/cclm-2025-8020
Recruitment, Education and Training of workforces in Laboratory Medicineon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s2355-s2365. doi: 10.1515/cclm-2025-8065. Print 2025 May 26. NO ABSTRACT PMID:40314547 | DOI:10.1515/cclm-2025-8065
Endocrinologyon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 2;63(s1):s1118-s1280. doi: 10.1515/cclm-2025-8045. Print 2025 May 26. NO ABSTRACT PMID:40314546 | DOI:10.1515/cclm-2025-8045
Quality Control Measurements Yield Similar Variation Below and Above Limit of Quantification for High-Sensitivity Cardiac Troponin I Assays May 2, 2025 Clin Chem. 2025 May 2:hvaf057. doi: 10.1093/clinchem/hvaf057. Online ahead of print. NO ABSTRACT PMID:40314142 | DOI:10.1093/clinchem/hvaf057
Comprehensive assessment of medical laboratory performance: a 4D model of quality, economics, velocity, and productivity indicatorsPavel S Zubanovon May 2, 2025 at 10:00 am May 2, 2025 Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0323. Online ahead of print. ABSTRACT Laboratory diagnostics play a crucial role in modern medicine and healthcare economics. The effective management of …
Read more Pre-analytical phase errors constitute the vast majority of errors in clinical laboratory testingYanchun Linon May 1, 2025 at 10:00 am May 1, 2025 Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0190. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory errors pose a threat to patient safety and previous studies have demonstrated that …
Read more Promising protein biomarkers for early gastric cancer: clinical performance of combined detectionWeifeng Shenon April 30, 2025 at 10:00 am April 30, 2025 Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2024-1510. Online ahead of print. ABSTRACT OBJECTIVES: In the early stage of gastric cancer (GC), identifying cancer-specific biomarkers is a key step …
Read more Beyond the Hydrashift assay: the utility of isoelectric focusing for therapeutic antibody and paraprotein detectionRieke Reiteron April 30, 2025 at 10:00 am April 30, 2025 Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0352. Online ahead of print. ABSTRACT OBJECTIVES: In serum immunofixation electrophoresis, therapeutic monoclonal antibodies (tmAbs) can be misinterpreted as paraproteins. Strategies to …
Read more Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practicesWeiyan Zhouon April 30, 2025 at 10:00 am April 30, 2025 Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0186. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) is critical for optimizing antipsychotic therapy, yet inter-laboratory comparability in China …
Read more Performance of the Binding Site cerebrospinal fluid kappa free light chains assaySimon Alfred Handley, Suzanne Barnes, Nicole Jenkins, Troy Wanandy1Biochemistry, Department of Pathology, 34379Royal Hobart Hospital, Hobart, TAS, Australia2College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia3Department of Special Chemistry, Pathwest QE II MC, Nedlands, WA, Australia4Clinical Biochemistry, Alfred Pathology Service, Melbourne, VIC, Australia5Department of Clinical Immunology and Allergy, 34379Royal Hobart Hospital, Hobart, TAS, Australiaon April 12, 2025 at 2:47 am April 30, 2025 Annals of Clinical Biochemistry, Ahead of Print. BackgroundMeasurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative …
Read more Utilizing the Stability of Individual Homeostatic Setpoints over Time – A Step Forward on the Path to Personalized Laboratory Medicine April 29, 2025 Clin Chem. 2025 Apr 29:hvaf022. doi: 10.1093/clinchem/hvaf022. Online ahead of print. NO ABSTRACT PMID:40296580 | DOI:10.1093/clinchem/hvaf022
Thyroid reference ranges in pregnancy utilizing an Abbott Alinity platform in a multi-ethnic population in the UKRV Scott, M Abdel-Malek, J Zhu, J Tan, D Thayabaran, R Valaiyapathi, P Padam, E Jackson, SC Barnes, H Fourie, M Al-Memar, C Kyriacou, M Nimura, T Bourne, NG Martin, R Agha-Jaffar, B Jones, B Khoo, TM-M Tan1Department of Endocrinology, 9762Chelsea & Westminster Hospital, London, UK2Department of Metabolism, Digestion and Reproduction, 4615Imperial College London, London, UK3Blood Sciences, North West London Pathology, Charing Cross Hospital, London, UK4Tommy’s National Centre for Miscarriage Research, Queen Charlotte’s and Chelsea Hospital, 4615Imperial College London, London, UK5Department of Development and Regeneration, KU Leuven, Leuven, Belgium6Department of Gynaecology, University Hospital Leuven, Leuven, Belgium7Department of Endocrinology, 8946Imperial College Healthcare NHS Trust, London, UK8Department of Obstetrics and Gynaecology, 8946Imperial College Healthcare NHS Trust, London, UK9Department of Endocrinology, Division of Medicine, University College London, London, UKon March 29, 2025 at 6:01 am April 29, 2025 Annals of Clinical Biochemistry, Ahead of Print. BackgroundMaternal thyroid function significantly affects fetal development. However, thyroid hormone concentrations change dynamically throughout pregnancy rendering non-pregnancy reference ranges inaccurate. We aimed to …
Read more A Professional Skeptic April 28, 2025 Clin Chem. 2025 Apr 28:hvaf049. doi: 10.1093/clinchem/hvaf049. Online ahead of print. NO ABSTRACT PMID:40289257 | DOI:10.1093/clinchem/hvaf049
IFCC recommendations for internal quality control practice: a missed opportunityHikmet Can Çubukçuon April 27, 2025 at 10:00 am April 27, 2025 Clin Chem Lab Med. 2025 Apr 28. doi: 10.1515/cclm-2025-0486. Online ahead of print. ABSTRACT The IFCC Task Force on Global Lab Quality (TF-GLQ) has recently released a new guidance for …
Read more The Utility of the Immunoglobulin A Flag Used in Celiac Disease Serology Testing on a Particle-Based Multianalyte Technology Platform April 25, 2025 Clin Chem. 2025 Apr 25:hvaf047. doi: 10.1093/clinchem/hvaf047. Online ahead of print. NO ABSTRACT PMID:40279097 | DOI:10.1093/clinchem/hvaf047
Contradictory definitions give rise to demands for a right to unambiguous definitionsChristoph Buchtaon April 25, 2025 at 10:00 am April 25, 2025 Clin Chem Lab Med. 2025 Apr 28. doi: 10.1515/cclm-2025-0402. Online ahead of print. NO ABSTRACT PMID:40277334 | DOI:10.1515/cclm-2025-0402
Reconciling reference ranges and clinical decision limits: the case of thyroid stimulating hormoneLuca Giovanellaon April 25, 2025 at 10:00 am April 25, 2025 Clin Chem Lab Med. 2025 Apr 28. doi: 10.1515/cclm-2025-0483. Online ahead of print. NO ABSTRACT PMID:40277300 | DOI:10.1515/cclm-2025-0483
A physio-chemical mathematical model of the effects of blood analysis delay on acid-base, metabolite and electrolyte status: evaluation in blood from critical care patientsBahareh Nevirianon April 25, 2025 at 10:00 am April 25, 2025 Clin Chem Lab Med. 2024 Dec 31;63(6):1139-1152. doi: 10.1515/cclm-2024-1350. Print 2025 May 26. ABSTRACT OBJECTIVES: Measurements of acid-base status are performed quickly after blood sampling avoiding errors. This necessitates rapid …
Read more Potential coeliac disease in children: a single-center experienceLuisa Lonoceon April 24, 2025 at 10:00 am April 24, 2025 Clin Chem Lab Med. 2025 Apr 25. doi: 10.1515/cclm-2025-0098. Online ahead of print. ABSTRACT OBJECTIVES: Potential coeliac disease (PCD) is defined by the presence of positive CD-specific autoantibodies with a …
Read more A Comprehensive Assessment of Metagenomic cfDNA Sequencing for Microbe Detection April 24, 2025 Clin Chem. 2025 Apr 24:hvaf044. doi: 10.1093/clinchem/hvaf044. Online ahead of print. ABSTRACT BACKGROUND: Metagenomic cell-free DNA (cfDNA) sequencing provides a new avenue for diagnosing infectious diseases. Owing to the low …
Read more MIQE 2.0: Revision of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments Guidelines April 24, 2025 Clin Chem. 2025 Apr 24:hvaf043. doi: 10.1093/clinchem/hvaf043. Online ahead of print. ABSTRACT BACKGROUND: In 2009, the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines established standards for …
Read more The Need for Better Validation: Evaluating Aptamer and Proximity Extension Assays for Large-Scale Clinical Proteomics Studies April 24, 2025 Clin Chem. 2025 Apr 24:hvaf046. doi: 10.1093/clinchem/hvaf046. Online ahead of print. NO ABSTRACT PMID:40272410 | DOI:10.1093/clinchem/hvaf046
Development of commutable candidate certified reference materials from protein solutions: concept and application to human insulinShiwen Luoon April 24, 2025 at 10:00 am April 24, 2025 Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0329. Online ahead of print. ABSTRACT OBJECTIVES: To explore the reasons behind the lack of commutability in protein solution reference materials (RMs) …
Read more Biological variation of serum cholinesterase activity in healthy subjectsEmiş Deniz Akbuluton April 23, 2025 at 10:00 am April 23, 2025 Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0240. Online ahead of print. ABSTRACT OBJECTIVES: Serum cholinesterase (ChE) 3.1.1.8 is measured to assess exposure to organophosphorus pesticides and determine deficiency …
Read more New insights in preanalytical qualityMario Plebanion April 23, 2025 at 10:00 am April 23, 2025 Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0478. Online ahead of print. ABSTRACT The negative impact of preanalytical errors on the quality of laboratory testing is now universally recognized. …
Read more 10th Annual Meeting of the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC)on April 23, 2025 at 10:00 am April 23, 2025 Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0469. Online ahead of print. NO ABSTRACT PMID:40266015 | DOI:10.1515/cclm-2025-0469
Proteomic Aging Clock Predicts Mortality and Risk of Common Age-Related Diseases April 21, 2025 Clin Chem. 2025 Apr 21:hvaf041. doi: 10.1093/clinchem/hvaf041. Online ahead of print. NO ABSTRACT PMID:40256863 | DOI:10.1093/clinchem/hvaf041
Impact of renal function impairment on kappa free light chain indexMartin Schmidaueron April 19, 2025 at 10:00 am April 20, 2025 Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0007. Online ahead of print. ABSTRACT OBJECTIVES: To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. METHODS: Patients with …
Read more Strengthening international cooperation and confidence in the field of laboratory medicine by ISO standardizationFolker Spitzenbergeron April 18, 2025 at 10:00 am April 18, 2025 Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0442. Online ahead of print. NO ABSTRACT PMID:40249900 | DOI:10.1515/cclm-2025-0442
Evaluation of error detection and treatment recommendations in nucleic acid test reports using ChatGPT modelsWenzheng Hanon April 18, 2025 at 10:00 am April 18, 2025 Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0089. Online ahead of print. ABSTRACT OBJECTIVES: Accurate medical laboratory reports are essential for delivering high-quality healthcare. Recently, advanced artificial intelligence models, …
Read more The accuracy of presepsin in diagnosing neonatal late-onset sepsis in critically ill neonates: a prospective studyCinzia Aurition April 18, 2025 at 10:00 am April 18, 2025 Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0128. Online ahead of print. ABSTRACT OBJECTIVES: The diagnostic accuracy of presepsin (P-SEP) in the newborn is still under evaluation. METHODS: In …
Read more A Comprehensive Review of Estradiol, Progesterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in the Context of Laboratory Medicine to Support Women’s Health April 18, 2025 Clin Chem. 2025 Apr 18:hvaf039. doi: 10.1093/clinchem/hvaf039. Online ahead of print. ABSTRACT BACKGROUND: There have been conflicting messages about the influence of female sex hormones on women’s health, with historical …
Read more Direct screening and quantification of monoclonal immunoglobulins in serum using MALDI-TOF mass spectrometry without antibody enrichmentHou-Long Luoon April 17, 2025 at 10:00 am April 17, 2025 Clin Chem Lab Med. 2025 Apr 18. doi: 10.1515/cclm-2025-0203. Online ahead of print. ABSTRACT OBJECTIVES: Monoclonal gammopathies (MGs) are characterized by the presence of monoclonal immunoglobulins (M-proteins). Currently, recommendations for …
Read more The first case of Teclistamab interference with serum electrophoresis and immunofixationKamran Kadkhodaon April 17, 2025 at 10:00 am April 17, 2025 Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2025-0382. Online ahead of print. NO ABSTRACT PMID:40241333 | DOI:10.1515/cclm-2025-0382
A simpler and more sensitive modified catalytic (bleomycin detectable) iron assayMohan M Rajapurkar, Banibrata Mukhopadhyay, Suhas S Lele, Sudhir V Shah129025Muljibhai Patel Urological Hospital, Nadiad, India212215University of Arkansas for Medical Sciences, Little Rock, AR, USAon March 14, 2025 at 4:48 am April 17, 2025 Annals of Clinical Biochemistry, Ahead of Print. BackgroundIron is ubiquitously distributed in biology, only a miniscule amount exists as free is capable of catalysing production of highly toxic reactive hydroxyl …
Read more Reevaluating the Threshold for Low Total Testosterone April 16, 2025 Clin Chem. 2025 Apr 16:hvaf025. doi: 10.1093/clinchem/hvaf025. Online ahead of print. NO ABSTRACT PMID:40238540 | DOI:10.1093/clinchem/hvaf025
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisone in human serum and plasmaMyriam Otton April 16, 2025 at 10:00 am April 16, 2025 Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2024-1478. Online ahead of print. ABSTRACT OBJECTIVES: Cortisone is an inert precursor/metabolite of the potent steroid hormone cortisol. Measurement of serum cortisone …
Read more Help Us to Help You: Recommendations for Continued Enforcement Discretion for Common Infectious Disease Test Modifications under the FDA Final Rule April 16, 2025 Clin Chem. 2025 Apr 16:hvaf018. doi: 10.1093/clinchem/hvaf018. Online ahead of print. NO ABSTRACT PMID:40238134 | DOI:10.1093/clinchem/hvaf018
Cardiac Biomarkers in Pulmonary Embolism: Revealing or Redundant? April 16, 2025 Clin Chem. 2025 Apr 16:hvaf019. doi: 10.1093/clinchem/hvaf019. Online ahead of print. NO ABSTRACT PMID:40238127 | DOI:10.1093/clinchem/hvaf019
Evaluation of sex-specific 0-h high-sensitivity cardiac troponin T thresholds for the risk stratification of non-ST-segment elevation myocardial infarctionAilun Zhangon April 16, 2025 at 10:00 am April 16, 2025 Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2024-1118. Online ahead of print. ABSTRACT OBJECTIVES: We aimed to evaluate sex-specific 0-h high-sensitivity cardiac troponin T (hs-cTnT) thresholds for risk stratification …
Read more Reviewer Acknowledgmenton April 15, 2025 at 10:00 am April 15, 2025 Clin Chem Lab Med. 2025 Nov 28;63(1):220-223. doi: 10.1515/cclm-2024-2001. Print 2025 Jan 29. NO ABSTRACT PMID:40230253 | DOI:10.1515/cclm-2024-2001
Vancomycin assay interference: low-level IgM paraprotein disrupts Siemens Atellica® CH VANC assayStijn De Koninckon April 14, 2025 at 10:00 am April 14, 2025 Clin Chem Lab Med. 2025 Apr 16. doi: 10.1515/cclm-2025-0251. Online ahead of print. NO ABSTRACT PMID:40228303 | DOI:10.1515/cclm-2025-0251
Digital metrology in laboratory medicine: a call for bringing order to chaos to facilitate precision diagnosticsMadeleen Bosmaon April 14, 2025 at 10:00 am April 14, 2025 Clin Chem Lab Med. 2025 Apr 16. doi: 10.1515/cclm-2025-0152. Online ahead of print. ABSTRACT Laboratory medicine is faced with rapid developments in data exchange, secondary use of data and artificial …
Read more Assessment of serum free light chain measurements in a large Chinese chronic kidney disease cohort: a multicenter real-world studyXia Luoon April 11, 2025 at 10:00 am April 11, 2025 Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2024-1226. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing monoclonal gammopathy in chronic kidney disease (CKD) patients is challenging due to the complex …
Read more Defining dried blood spot diameter: implications for measurement and specimen rejection ratesNick Flynnon April 11, 2025 at 10:00 am April 11, 2025 Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2025-0183. Online ahead of print. ABSTRACT OBJECTIVES: Dried blood spot (DBS) specimen acceptance guidelines recommend rejecting specimens based on DBS size, often …
Read more Dr. Morley Donald Hollenberg. An extraordinary scientist, teacher and mentorKaterina Oikonomopoulouon April 10, 2025 at 10:00 am April 10, 2025 Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0405. Online ahead of print. NO ABSTRACT PMID:40205943 | DOI:10.1515/cclm-2025-0405
Clostebol detection after transdermal and transmucosal contact. A systematic reviewVincenzo Giannicola Mendittoon April 10, 2025 at 10:00 am April 10, 2025 Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0331. Online ahead of print. ABSTRACT INTRODUCTION: To analyze the available evidence about the correlation between the presence of detectable amounts of …
Read more Cascading referencing of terms and definitionsChristoph Buchtaon April 10, 2025 at 10:00 am April 10, 2025 Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0144. Online ahead of print. NO ABSTRACT PMID:40205954 | DOI:10.1515/cclm-2025-0144
Supporting prioritization efforts of higher-order reference providers using evidence from the Joint Committee for Traceability in Laboratory Medicine databaseMauro Panteghinion April 10, 2025 at 10:00 am April 10, 2025 Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0401. Online ahead of print. ABSTRACT The Joint Committee for Traceability in Laboratory Medicine (JCTLM) database represents a valuable resource for implementing …
Read more Cell population data for early detection of sepsis in patients with suspected infection in the emergency departmentMarta Cancella De Abreuon April 10, 2025 at 10:00 am April 10, 2025 Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0180. Online ahead of print. ABSTRACT OBJECTIVES: Traditional biomarkers used for sepsis diagnosis have limited sensitivity and specificity and, so far, are …
Read more Instrument Multiplexing: Amplified Throughput for Measurement of Vitamin B1 in Whole Blood Using Parallel Liquid Chromatography Systems Interfaced to a Single Mass Spectrometer April 9, 2025 Clin Chem. 2025 Apr 9:hvaf029. doi: 10.1093/clinchem/hvaf029. Online ahead of print. ABSTRACT BACKGROUND: Thiamine diphosphate (TDP), the active form of vitamin B1, plays an essential role in energy metabolism. TDP …
Read more Clinical vs. statistical significance: considerations for clinical laboratoriesHamit Hakan Alpon April 8, 2025 at 10:00 am April 8, 2025 Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2025-0219. Online ahead of print. ABSTRACT Amongst the main perspectives when evaluating the results of medical studies are statistical significance (following formal …
Read more Liquid chromatography tandem mass spectrometry (LC-MS/MS) candidate reference measurement procedure for urine albuminSeiei Shibaon April 8, 2025 at 10:00 am April 8, 2025 Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2024-1374. Online ahead of print. ABSTRACT OBJECTIVES: Urine albumin is a key biomarker utilized for diagnosis and monitoring progression of chronic kidney …
Read more IgA-type macroprolactin among 130 patients with macroprolactinemiaMasayuki Ishiharaon April 8, 2025 at 10:00 am April 8, 2025 Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2025-0264. Online ahead of print. ABSTRACT OBJECTIVES: Macroprolactin (macro-PRL) mostly comprises a complex of PRL with IgG. The aim of this study …
Read more Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes April 7, 2025 Clin Chem. 2025 Apr 7:hvaf035. doi: 10.1093/clinchem/hvaf035. Online ahead of print. ABSTRACT BACKGROUND: Methylglyoxal (MGO) is a potent glycating agent that contributes to the pathogenesis of diabetes. However, MGO is …
Read more Toward Improved Prostate Cancer Screening: Insights from the Göteborg-2 Trial April 4, 2025 Clin Chem. 2025 Apr 4:hvaf032. doi: 10.1093/clinchem/hvaf032. Online ahead of print. NO ABSTRACT PMID:40183422 | DOI:10.1093/clinchem/hvaf032
Prevalence and re-evaluation of macroprolactinemia in hyperprolactinemic patients: a retrospective study in the Turkish populationOsman Oğuzon April 4, 2025 at 10:00 am April 4, 2025 Clin Chem Lab Med. 2025 Apr 7. doi: 10.1515/cclm-2025-0177. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to investigate the prevalence of macroprolactinemia and the changes in hyperprolactinemia status …
Read more Screening primary aldosteronism by plasma aldosterone-to-angiotensin II ratioClara Wai-Shan Loon April 4, 2025 at 10:00 am April 4, 2025 Clin Chem Lab Med. 2025 Apr 7. doi: 10.1515/cclm-2024-1312. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is a common cause of secondary hypertension. The aldosterone-to-renin ratio (ARR) is …
Read more New Clinical Practice Guidelines for Vitamin D Supplementation and Testing April 3, 2025 Clin Chem. 2025 Apr 3;71(4):526-528. doi: 10.1093/clinchem/hvae213. NO ABSTRACT PMID:40178549 | DOI:10.1093/clinchem/hvae213
Commentary on Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations April 3, 2025 Clin Chem. 2025 Apr 3;71(4):449. doi: 10.1093/clinchem/hvae205. NO ABSTRACT PMID:40178548 | DOI:10.1093/clinchem/hvae205
Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations April 3, 2025 Clin Chem. 2025 Apr 3;71(4):445-448. doi: 10.1093/clinchem/hvae177. NO ABSTRACT PMID:40178547 | DOI:10.1093/clinchem/hvae177
Commentary on Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations April 3, 2025 Clin Chem. 2025 Apr 3;71(4):450. doi: 10.1093/clinchem/hvae197. NO ABSTRACT PMID:40178546 | DOI:10.1093/clinchem/hvae197
Mannose Phosphate Isomerase Deficiency-Congenital Disorder of Glycosylation (MPI-CDG) Type 1b: Familial Case of Thrombophilia and Liver Disorder April 3, 2025 Clin Chem. 2025 Apr 3;71(4):523-525. doi: 10.1093/clinchem/hvaf009. NO ABSTRACT PMID:40178550 | DOI:10.1093/clinchem/hvaf009
Improving the efficiency of quality control in clinical laboratory with an integrated PBRTQC system based on patient riskXincen Duanon April 3, 2025 at 10:00 am April 3, 2025 Clin Chem Lab Med. 2025 Apr 4. doi: 10.1515/cclm-2025-0163. Online ahead of print. ABSTRACT OBJECTIVES: Recent advances in information technology have renewed interest in patient-based real-time quality control (PBRTQC) as …
Read more Underreporting of synthetic cathinone poisoning with clinical immunoassays: An experimental and observational studyThéo Willeman, Mathis Laudet, Bruno Revol, Coralie Boudin, Hélène Eysseric-Guerin, Virginie Scolan, Françoise Stanke-Labesque1Laboratoire de Pharmacologie, Pharmacogénétique et Toxicologie, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France2Clinique de Médecine Légale, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France3CEIP-Addictovigilance, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France4Laboratoire HP2 Inserm U1300, 27015University Grenoble Alpes, Grenoble, France5Laboratoire de Médecine Légale, 27015University Grenoble Alpes, Grenoble, Franceon March 22, 2025 at 3:44 am April 3, 2025 Annals of Clinical Biochemistry, Ahead of Print. BackgroundThere is an increasing global concern about the use of synthetic cathinones (SCs). Detecting these drugs in human urine samples can be difficult, …
Read more Sigma metrics for assessing the analytical performance of 14 biochemical analytes in Mansoura university children’s hospital laboratories (MUCHLs) using CLIA LIMITS 1988 & 2024Nada Karam, Reham M El-Farahaty, Abdel- Hady El-Gilany, Nessma A Nosser1Clinical Pathology Department, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypt2Public Health & Preventive Medicine, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypton March 14, 2025 at 4:51 am April 3, 2025 Annals of Clinical Biochemistry, Ahead of Print. IntroductionAnalytical quality is a crucial prerequisite for best practice in medical laboratory. Six-Sigma Methodology (SM) is a quality measurement tool used to evaluate …
Read more Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma April 2, 2025 Clin Chem. 2025 Apr 2:hvaf030. doi: 10.1093/clinchem/hvaf030. Online ahead of print. ABSTRACT INTRODUCTION: The number of assays on proteomic platforms has grown rapidly. The leading platforms, SomaScan and Olink, have …
Read more Self-sampling of capillary blood for safety monitoring of DMARD therapy in patients with rheumatic disease: a feasibility and method-comparison studyJosefine Bak H. Adelhelm Trine Rennebod Larsen Ulla Jakobsen Pernille J. Vinholt Maria Boysen Sandberg Inger Marie Jensen Hansen Søren Andreas Just a Department of Clinical Biochemistry, Odense University Hospital, Odense C, Denmarkb Department of Clinical Biochemistry, Odense University Hospital, Svendborg, Denmarkc Department of Medicine, Section of Rheumatology, Svendborg Hospital – Odense University Hospital, Svendborg, Denmarkon February 7, 2025 at 5:34 am April 1, 2025 Volume 85, Issue 2, April 2025, Page 108-115.
Comparison of two automated immunoassays for quantifying ProGRP, SCC and HE4 in serum: impact on diagnostic accuracyJaime I. Sainz de Medrano Javier Laguna Judit Julian Xavier Filella Aleix Fabregat María Luquin Harol H. Hurtado Alba García Humanes Manuel Morales-Ruiz Esther Fernández-Galán a Biochemistry and Molecular Genetics Department-CDB, Hospital Clínic of Barcelona, Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), Barcelona, Spainb Servicio de Análisis Clínicos, Hospital Universitario de Navarra, Pamplona, Spainc Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spaind Commission for the Biochemical Evaluation of the Hepatic Disease-SEQCML, Barcelona, Spaine Biomedicine Department, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spainon February 15, 2025 at 5:28 am April 1, 2025 Volume 85, Issue 2, April 2025, Page 116-124.
Assessment of large language models in medical quizzes for clinical chemistry and laboratory management: implications and applications for healthcare artificial intelligenceWon Young Heo Hyung-Doo Park a Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Koreab Department of Laboratory Medicine, Gimpo Woori Hospital, Gimpo, Koreac Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University School of Medicine, Seoul, Koreaon February 19, 2025 at 6:06 am April 1, 2025 Volume 85, Issue 2, April 2025, Page 125-132.
The HUNT study: long-term within-subject variation of thyroid stimulating hormone (TSH)Arne Åsberg Marius Berg Gunhild Garmo Hov Ingrid Alsos Lian Lena Løfblad Gustav Mikkelsen a Department of Clinical Chemistry, St. Olav’s Hospital, Trondheim, Norwayb Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norwayon March 8, 2025 at 12:52 pm April 1, 2025 Volume 85, Issue 2, April 2025, Page 143-147.
A deep dive into four thyroglobulin immunoassays from analytical perspectiveTuba Saadet Deveci Bulut Muhittin Abdulkadir Serdar Mehmet Muhittin Yalçın Meriç Coşkun Aylar Poyraz Seda Gökgöz Acar Gizem Yaz Aydın Özlem Gülbahar a Department of Medical Biochemistry, Gazi University School of Medicine, Ankara, Turkeyb Department of Medical Biochemistry, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkeyc Department of Endocrinology and Metabolism, Gazi University School of Medicine, Ankara, Turkeyd Department of Pathology, Gazi University School of Medicine, Ankara, Turkeyon March 17, 2025 at 12:42 pm April 1, 2025 Volume 85, Issue 2, April 2025, Page 148-159.
Performance of enzymatic creatinine methods in the pediatric concentration rangeHilda Hallander Magnus Lindén Catarina Lindqvist Anders Olsson Sara Marie Larsson a Department of Clinical Chemistry, Halland Hospital, Varberg and Halmstad, Swedenb Department of Pediatrics, Halland Hospital, Halmstad, Swedenc Department of Pediatrics, Institute of Medical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Swedend Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Swedene Department of Clinical Sciences Lund, Pediatrics, Lund University, Lund, Swedenon February 17, 2025 at 1:35 am April 1, 2025 Volume 85, Issue 2, April 2025, Page 93-100.
