Machine learning-aided serum N-glycomic signatures reveal potential biomarkers for acute ischemic stroke and minocycline treatment responseon October 15, 2026 at 1:49 pm October 15, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Jun Li, Zhou Qiu, Xin Zheng, Runyu Xia, Hou Qian, Weifeng Li, Yufan Wu, Bo Pan, Xuemei Wang, …
Read more LC–MS/MS quantification of trimethylamine N-oxide in plasma and volumetric absorptive microsamples: analytical validation and feasibility in pediatric kidney transplant recipientson October 14, 2026 at 1:26 pm October 14, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Paweł Czarnowski, Agnieszka Czajkowska, Jacek Rubik, Arkadiusz Kocur
Cardiac troponin autoantibodies and cancer therapy-related cardiac dysfunction in breast cancer patients receiving anthracycline treatment: secondary analysis of the PRADA studyon October 14, 2026 at 1:26 pm October 14, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Helea Junes, Victoria Vinje-Jakobsen, Siri L. Heck, Geeta Gulati, Torbjørn Omland, Saara Wittfooth
From promise to practice: Assessing middleware characteristics in autoimmune diagnosticson October 14, 2026 at 1:26 pm October 14, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Emirena Garrafa, Brunetta Porcelli, Valentina Muraro, Rocco Negri, Barbara Casolari, Maria Infantino, Giampaola Pesce, Nicola Bizzaro
RefInterval studio: development of a guided R shiny workflow for establishing discrete and age-continuous reference intervalson October 10, 2026 at 10:42 am October 10, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Ma Chaochao, Zhou Haoyi, Cheng Xinqi, Chen Shi, Pang Haiyu, Xu Tengda, Wang Danchen, Hou Lian, Qiu Ling …
Read more Study of biallelic variants in CYP2R1 causing vitamin D hydroxylation deficiency rickets type 1Bon October 10, 2026 at 10:42 am October 10, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Jiasheng Zhang, Yuhui Huang, Juan Li, Wan Huai, Xin Li, Yanrong Qing, Ruen Yao, Xiumin Wang, Tingting Yu, …
Read more Soluble suppression of tumorigenicity 2 and cardiovascular outcomes across serum uric acid strata in maintenance hemodialysis: an exploratory secondary analysison October 9, 2026 at 9:48 am October 9, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Yiqi Su, Zhen Zhang, Liyu Lin, Jie Teng, Xiaoqiang Ding, Jianzhou Zou
Impact of ISO/TS 20914-based measurement uncertainty on HbA1c classification around clinical decision limits: A real-world evaluation of two analytical systemson October 9, 2026 at 9:48 am October 9, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Ahmet Burak Gürpınar, Canan Karadağ, Muzaffer Katar
Performance assessment of a novel fully automated ELISA for anti-IA2 autoantibody detection in type 1 diabeteson October 8, 2026 at 9:07 am October 8, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Martina Lehmann, Gia-Gia Toni Hò, Petra Augstein, Malgorzata Baranowska-Dell, Cornelia Dähnrich, Andrea Deerberg, Sandra Saschenbrecker, Wolfgang Kerner, Lars …
Read more A rapid sequential salting-out/isoelectric precipitation LC-MS/MS method for quantifying cytokeratin 18 in human ascitic fluidon October 8, 2026 at 9:07 am October 8, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Zhenni Liu, Xiaohua Xiao, Bingchu Li, Nijiao Qin, Ziyang Li, Xing Lyu, Zhongyuan Xiang, Min Hu, Qichen Long …
Read more Comparative diagnostic utility of cerebrospinal fluid biomarkers in multiple sclerosison October 7, 2026 at 2:33 pm October 7, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Basant Rashad, Sohair K. Sayed, Tarek A. Rageh, Eman R. Badawy, Dalia T. Kamal
Hemoglobin-normalized thiamine diphosphate (vitamin B1) in whole blood: Reference intervals and clinical implications for status assessmenton October 7, 2026 at 11:28 am October 7, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Sybille Guihaire, Damien Denimal
A novel γ-chain Tyr306Asn missense mutation causes congenital dysfibrinogenemiaon October 6, 2026 at 2:02 pm October 6, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Yangyang Wu, Lu He, Chen Qian, Meiling Luo, Qinghui Luo, Liqun Xiang, Min Chen, Xinyan Chen, Lin Liao, …
Read more A new indicator of cobalamin deficiencyon October 6, 2026 at 1:00 pm October 6, 2026 Publication date: December 2026 Source: Practical Laboratory Medicine, Volume 52 Author(s): Arne Åsberg, Øyvind Skadberg
Kidney-specific cell-free DNA as biomarker of kidney injury: Development and exploration of a multiplex digital droplet PCR assayon October 6, 2026 at 10:58 am October 6, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Ann-Maria Gramkow, Mads Malik Aagaard Jørgensen, Helle Charlotte Thiesson, Rikke Fredslund Andersen
Association between elevated serum cobalamin concentrations and malignancy: a retrospective cohort study from the western Cape, South Africaon October 6, 2026 at 10:58 am October 6, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Craig J. Andrews, Sa’ad Lahri, Tonya M. Esterhuizen, Annalise E. Zemlin, Thumeka P. Jalavu
Adjustment and validation of convolutional neural network for indirect immunofluorescence interpretation of antinuclear and anti-neutrophil cytoplasmic antibodies: A multicenter studyon October 2, 2026 at 12:04 pm October 2, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Rulin Jia, Yun Li, Jing Hu, Xianzi Cong, Yinxue Ma, Jianping Guo, Zhiyan Li, Haiping Zhang
Three FBN1 pathogenic variants in Chinese patients with Marfan syndrome: Two novel variants including a splicing-altering deletion with functional verificationon October 2, 2026 at 12:04 pm October 2, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Xing Zhao, Lamei Yuan, Yan Sun, Hong Xia, Pengzhi Hu, Hongbo Xu, Lina Gong, Hao Deng
Classification of serum protein and immunofixation electrophoresis images by computer vision-based deep learning models: A single- and dual-modality studyMaide Hacer Alagöz, Simge Erdem, Poyraz Doğan, İbrahim Utku Derman, Mehmet Güven Günver, Özlem Çakır Madenci, Evin Ademoğlu1Kartal Dr Lütfi Kırdar City Hospital, Biochemistry Laboratory, University of Health Sciences, İstanbul, Türkiye2İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul University, İstanbul, Türkiye3İstanbul Faculty of Medicine, İstanbul University, İstanbul, Türkiye4Faculty of Engineering, Boğaziçi University, İstanbul, Türkiye5İstanbul Faculty of Medicine, Department of Biostatistics, İstanbul University Türkiye, İstanbul, Türkiye6İstanbul Faculty of Medicine, Department of Medical Biochemistry, İstanbul University, İstanbul, Türkiyeon May 13, 2026 at 11:19 am October 2, 2026 Annals of Clinical Biochemistry, Ahead of Print. ObjectivesThe objective of this study was to develop deep learning models for the automated classification of serum protein electrophoresis (SPE) and immunofixation electrophoresis …
Read more Awareness, attitudes, and perceived barriers to artificial intelligence adoption in Turkish clinical biochemistry laboratories: An exploratory cross-sectional surveySaid İncir, Kerim Erhan Palaoğlu, Osman Oğuz, Ayşegül Özgenç, Yunus Gören, Deniz İlhan Topcu, Dildar Konukoğlu1Department of Medical Biochemistry, Koç University School of Medicine, İstanbul, Türkiye2587267Clinical Laboratory, Koç University Hospital, İstanbul, Türkiye3Clinical Laboratory, VKV American Hospital, İstanbul, Türkiye4723887Department of Clinical Biochemistry, TC Sağlık Bakanlığı Gaziantep Şehir Hastanesi, Gaziantep, Türkiye5680000Department of Medical Biochemistry, TC Sağlık Bakanlığı İzmir Şehir Hastanesi, İzmir, Türkiye6532719İstanbul Üniversitesi-Cerrahpaşa, Istanbul, Türkiyeon May 13, 2026 at 2:37 am October 2, 2026 Annals of Clinical Biochemistry, Ahead of Print. BackgroundArtificial intelligence (AI) is increasingly recognized as transformative in laboratory medicine, yet adoption lags behind radiology and cardiology. Limited data exist on AI-related …
Read more Analytical Validation of a MALDI-TOF Mass Spectrometry Method for Serum IGF-1 Measurement and Its Comparison with LC-MS/MS and CLIAon October 1, 2026 at 1:24 pm October 1, 2026 Publication date: Available online 30 September 2026 Source: Practical Laboratory Medicine Author(s): Ruiquan Cao, Huan Ding, Yong Xia, Xueting Ma, Anping Xu, Hou-Long Luo, Ling Ji
Three failure modes, three remedies: a creatinine-triggered reflex for pediatric urine drug screeningon October 1, 2026 at 11:15 am October 1, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Nezihe Köker Özer, Ercan Yılmaz, Didem Tatar
A capillary electrophoresis-derived nomogram for identifying IgM monoclonal proteins missed by serum protein electrophoresison September 30, 2026 at 1:39 pm September 30, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Fei Ding, Shanshan Liang, Yanhua Zhao, Chuanmin Tao, Wei Gan
Morphological changes in peripheral blood of patients with type I and type II cryoglobulinemiaon September 30, 2026 at 12:32 pm September 30, 2026 Publication date: Available online 29 September 2026 Source: Practical Laboratory Medicine Author(s): Shengli Sun, Geng Wang, Xin Wang, Zhejun Fang, Wei Wu
Long-term analytical drift of serum creatinine and its association with CKD staging consistency based on eGFR: a retrospective studyZhigang Yang Yuan Tian Yang Yang Department of Clinical Laboratory, The Fifth Hospital of Daqing City, Daqing, Heilongjiang, Chinaon September 25, 2026 at 9:18 am September 30, 2026 Volume 86, Issue 6, OCTOBER 2026, Page 593-605.
Paired comparisons and regression to the mean – with emphasis on graphical illustrationsBent Kristensen Mikkel Lausten Jensen Marc Østergaard Nielsen Arlinda Ljoki Johan Larsson Department of Nuclear Medicine, Herlev University Hospital, Herlev, Denmarkon September 23, 2026 at 7:45 am September 30, 2026 Volume 86, Issue 6, OCTOBER 2026, Page 659-676.
Fucosylated α-1-acid glycoprotein as a noninvasive fibrosis marker in chronic viral hepatitisCatharina Alexandersson Mats Haglund Eva Åström Karin Lindahl Kristina Cardell Peter Påhlsson Ingvar Rydén a Department of Infectious Diseases, Kalmar County Hospital, Kalmar, Swedenb Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Swedenc Department of Medicine, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Swedend Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Swedene Department of Infectious Diseases in Östergötland, Linköping University Hospital, Swedenf Department of Research, Region Kalmar County, Kalmar, Swedenon September 24, 2026 at 8:49 am September 30, 2026 Volume 86, Issue 6, OCTOBER 2026, Page 677-685.
Analysis of consistency in aspartate aminotransferase detection results and bias correction using reference materials as calibratorsFeiran Lin Pinqi Zhao Sheng Jiang Xiaoxuan Yu Danhong Ge Yuanzhu Ou Department of Clinical Chemistry and Immunology, Shanghai Center for Clinical Laboratory, Shanghai, Chinaon September 21, 2026 at 11:05 am September 30, 2026 Volume 86, Issue 6, OCTOBER 2026, Page 686-693.
The clinical impact of 131-iodine whole-body scintigraphy following 131-iodine therapy of thyroid cancerMira Simone Hofmann Julie Kjems Bo Zerahn Bent Kristensen Christian Maare Lars Thorbjørn Jensen a Department of Nuclear Medicine, Herlev University Hospital, The Capital Region, Denmarkb Department of Oncology, Herlev University Hospital, The Capital Region, Denmarkc Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmarkon September 26, 2026 at 2:22 am September 30, 2026 Volume 86, Issue 6, OCTOBER 2026, Page 694-701.
Machine learning-based discrimination of metabolic dysfunction-associated steatotic liver disease: implications of tryptophan metabolites as potential biomarkerson September 29, 2026 at 3:56 pm September 29, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Zhenni Liu, Siying Li, Yaxin Tan, Bingchu Li, Nijiao Qin, Peiting Liu, Fengfan Li, Zhiyang Chen, Ziyang Li, …
Read more A clinical decision support framework for automated M-protein isotype classification from capillary zone electrophoresis immunotyping signalson September 27, 2026 at 1:26 pm September 27, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Deniz İlhan Topcu, Nilüfer Bayraktar, Erdinç Devrim
Updated total calcium reference intervals for Abbott Alinity c using Calcium2 reagentson September 26, 2026 at 4:43 pm September 26, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Yasser Tabana, Vathany Kulasingam, Tobias Fischer, David Daghfal, Rajeevan Selvaratnam
Detection profiles of multiplex real-time PCR and culture for Streptococcus pneumoniae in pediatric lower respiratory tract infectionson September 25, 2026 at 11:41 am September 25, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Jing Guo, Weiyuan Zhuo, Chenglan Yan, Jialing Ruan, Linlin Li
Clinical utility of the lipemic index for identifying severe triglyceride-rich lipoprotein disorders in adults undergoing routine blood testingon September 24, 2026 at 5:15 pm September 24, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Pauline C.E. Schuitema, Hans Kemperman, Simone Smits, Cornelis A. Koekman, Wouter W. van Solinge, Raymond M. Schiffelers, A. …
Read more Biofluid iodine concentrations are associated with mild cognitive impairment: The potential mediating role of thyroid hormoneson September 24, 2026 at 5:15 pm September 24, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Zijian Jin, Pengxin Li, Yu Zhu, Meina Ji, Mingli Zheng, Xiwen Fu, Qi Jin, Ziyun Pan, Elizabeth N. …
Read more Ionized magnesium in serum measured using a blood gas analyser: Agreement with whole blood, short-term stability and preliminary reference interval in healthy adultson September 24, 2026 at 5:15 pm September 24, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Carlos Castillo Pérez, Purificación Jurado Parras, Raquel Ramos Corral
Beyond downtime: cybersecurity, analytical integrity, and laboratory quality in clinical biochemistryon September 24, 2026 at 3:12 pm September 24, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Prasenjit Mitra
IgE allergy testing utilization: next steps from a provincial quality improvement initiativeon September 23, 2026 at 2:36 pm September 23, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Michelle L. Parker, Victoria Higgins, Dustin T. Proctor, Timothy K. Vander Leek, Harissios Vliagoftis, Ling Ling, Mathew P. Estey
Identifying and Resolving Analytical Outliers in Lipoprotein(a) Immunoassay Testingon September 23, 2026 at 1:35 pm September 23, 2026 Publication date: Available online 22 September 2026 Source: Practical Laboratory Medicine Author(s): Jackson AN, Wyness SP, Rudolf JW, Genzen JR
Assay-dependent reclassification of biochemical hyperandrogenism in female androgen testing: CLIA versus LC-MS/MS under common clinical decision thresholdson September 23, 2026 at 10:30 am September 23, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Xianhua Zhang, Huiyu Xu, Lingling Liu, Li Yang, Rong Li, Rongsheng Zhao
Clinical utility of a dedicated vanishing twin analytical workflow in single-nucleotide variant-based non-invasive prenatal testing: a case report of resolving prolonged aneuploidy discordanceChanghee Haon September 22, 2026 at 10:00 am September 22, 2026 Clin Chem Lab Med. 2026 Sep 23. doi: 10.1515/cclm-2026-1330. Online ahead of print. NO ABSTRACT PMID:42770712 | DOI:10.1515/cclm-2026-1330
Season of sampling and the interpretation of serum homocysteine results: a within-person analysis of 268,877 health-screening examinationsSeung-Hwan Kimon September 22, 2026 at 10:00 am September 22, 2026 Clin Chem Lab Med. 2026 Sep 23. doi: 10.1515/cclm-2026-1304. Online ahead of print. ABSTRACT OBJECTIVES: Serum total homocysteine (tHcy) is interpreted against fixed reference intervals and a decision limit. Whether …
Read more Metabolic and liver enzyme correlates of serum alpha-fetoprotein in a large health check-up populationon September 22, 2026 at 9:56 am September 22, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Lu Zhou, Huan Wu, Tao Wu, Xinru Wang, Errui Song, Fan Su, Catherine Adaeze Ezeokafor, Yue Wu, Xinyu …
Read more Hematological and biochemical profiling of iron deficiency anemia among adolescent girls: A cross-sectional study from rural areas of the Jungle Mahal, West Bengal, Indiaon September 22, 2026 at 9:56 am September 22, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Sumita Rani Pradhan, Kartik Chandra Guchhait, Suparna Majumder, Debarati Jana, Biswajit Das, Mousumi Manna, Pradip Jana, Amiya Kumar …
Read more Thyroglobulin antibody in differentiated thyroid cancer: international laboratory practice survey and the case for a dual-threshold modelEliane F E Wenstedton September 21, 2026 at 10:00 am September 21, 2026 Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1063. Online ahead of print. ABSTRACT OBJECTIVES: Anti-thyroglobulin antibodies (TgAb) have a dual role during the follow-up of differentiated thyroid cancer (DTC): …
Read more Responsibility without a map: defining oversight of automated result release in the medical laboratorySaid İnciron September 21, 2026 at 10:00 am September 21, 2026 Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1371. Online ahead of print. ABSTRACT Laboratory specialists have been assigned responsibility for algorithmically assisted reporting without an operational definition of what …
Read more Diagnostic and prognostic performance of heart-type fatty acid–binding protein in functionally relevant coronary artery diseaseon September 21, 2026 at 9:26 am September 21, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Evangelos Tsianakas, Seval Kul, Fiona Nafaa, Koray Durak, Pedro Lopez-Ayala, Emel Kaplan, Gabrielle Huré, Alex Ritz, Luca Koechlin, …
Read more Delivering the EU Safe Hearts Plan: the essential role of laboratory medicine in cardiovascular healthDamien Grusonon September 20, 2026 at 10:00 am September 20, 2026 Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1439. Online ahead of print. ABSTRACT The European Union Safe Hearts Plan provides an opportunity to strengthen cardiovascular prevention, early detection, treatment, …
Read more Longitudinal trace element monitoring in haemodialysis patients: Impact of dialysis vintage and technical treatment factorson September 20, 2026 at 1:00 pm September 20, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Sara Valderrama-Sanz, Jordi Tortosa-Carreres, Nuria Rosell-Saiz, Ricardo Molina-Gasset, José-Luis Todolí-Torró
Filling the gaps in high-priority reference materials for implementing metrological traceability in laboratory medicineMauro Panteghinion September 19, 2026 at 10:00 am September 20, 2026 Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1332. Online ahead of print. ABSTRACT The global harmonization of measurements in laboratory medicine is facilitated by the development and implementation of …
Read more Medium-chain acyl-CoA dehydrogenase deficiency: A ten-year single-center case series from Indiaon September 19, 2026 at 2:21 pm September 19, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Radha Rama Devi Akella, Srilatha Kadali, Shaik Mohammad Naushad
Availability and characteristics of external quality assessment (EQA) schemes for measurement of hemolysis, icterus and lipemia (HIL) in routine coagulation testing, a collaborative study from the European Organisation for External Quality Assurance in Laboratory Medicine (EQALM)Ann Helen Kristoffersenon September 18, 2026 at 10:00 am September 18, 2026 Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1130. Online ahead of print. NO ABSTRACT PMID:42758902 | DOI:10.1515/cclm-2026-1130
The correct use of the unit symbols U/L and IU/LKuenyoul Parkon September 18, 2026 at 10:00 am September 18, 2026 Clin Chem Lab Med. 2026 Sep 21. doi: 10.1515/cclm-2026-1397. Online ahead of print. NO ABSTRACT PMID:42758900 | DOI:10.1515/cclm-2026-1397
Continuous versus discrete reference intervals for pediatric thyroid hormones: Clinical implications from a GAMLSS-based reclassification analysison September 18, 2026 at 1:35 pm September 18, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Merve Türkegün Şengül, Didem Derici, Saniye Başak Oktay
IgE allergy testing utilization: Implementation of a provincial quality improvement initiativeon September 18, 2026 at 11:32 am September 18, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Michelle L. Parker, Victoria Higgins, Dustin T. Proctor, Timothy K. Vander Leek, Harissios Vliagoftis, Ling Ling, Kara Robertson, Terence A. …
Read more Population-specific reference intervals for cystatin C, creatinine and urea, and their impact on diagnostic classification and eGFR stratification in Nigerian adultson September 17, 2026 at 4:54 pm September 17, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Imafidor Iyabode, Bruno Basil, Izuchukwu Nnachi Mba, Jamila Aminu Mohammed, Maxwell Nwegbu, Amos Ali Gadzama
Association of perfluoroalkyl and polyfluoroalkyl substances with polyendocrine metabolic ovarian syndrome and endocrine abnormalities: A case–control studyon September 17, 2026 at 12:50 pm September 17, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Guan Cheng, Fangning Li, Hongyu Li, Youran Li, Yan Cao, Ying Liu, Dan Huang, Wenxiang Liu, Mingwei Xin, …
Read more Corrigendum to “Maternal vaginal colonization screening for term singleton pregnancy: comparative evaluation of metagenomic next-generation sequencing (mNGS) versus real-time quantitative PCR (qPCR)” [Pract. Lab. Med. (2026) 542]on September 16, 2026 at 3:15 pm September 16, 2026 Publication date: September 2026 Source: Practical Laboratory Medicine, Volume 51 Author(s): Jinyu Zhang, Jingyi Liang, Fei Lv, Zhusheng Guo
Corrigendum to “Comparative analysis of diagnostic kits for detecting Ureaplasma spp. and M. hominis in genital and urinary samples” [Pract Lab Med, 49 (2026) 525]on September 16, 2026 at 3:15 pm September 16, 2026 Publication date: September 2026 Source: Practical Laboratory Medicine, Volume 51 Author(s): Juliette Beaucarne, Ivana Buttice, Nada Riahi, Ethel Seyll, Mony Hing, Bram Vanmechelen, Delphine Martiny
Establishing personalized reference intervals based on within-subject biological variation using real-world data and the refineR algorithmon September 16, 2026 at 10:07 am September 16, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Berkay Korkmaz, Ergin Çam, Alev Kural, Deniz İ. Topcu
Rapid myocardial infarction rule-out: A single high-sensitivity cardiac troponin I and T threshold strategy for the Chinese emergency departmenton September 15, 2026 at 5:32 pm September 15, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Yang Fangfang, LinYahui, Zhan Hong, Wang Shukui, Liu Min, Ye Zi, Liu Caidong, Feng Guangxun, Zhang Tao, Zhu …
Read more Digital and computational morphology in hematology: current platforms, clinical evidence, and future requirementsGina Zinion September 13, 2026 at 10:00 am September 13, 2026 Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1265. Online ahead of print. ABSTRACT INTRODUCTION: Morphologic examination of peripheral blood and bone marrow remains central to the diagnosis and classification …
Read more Likelihood ratios of ANCA fluorescence patterns and anti-MPO/PR3 antibody levels in ANCA-associated Vasculitis: A framework for refined diagnostic interpretationon September 13, 2026 at 2:33 pm September 13, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Qiongni Wang, Huijing Huang, Lijie Gong, Xiaowei Huang, Weiwei Mao, Xiaowei Ma, Bing Zheng
Site-specific glycosylation of serum antithrombin-III as a potential biomarker for AFP-negative HCCon September 13, 2026 at 10:25 am September 13, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Xinyi Cao, Zhao Cao, Huan Zeng, Yao Hu, Cuiping Zhang, Guoquan Yan, Lei Zhang, Hong Shu, Haojie Lu, …
Read more Reply to: Albumin-adjusted (“corrected”) calcium should no longer be reported: a position statement from the Joint IOF Working Group and IFCC Committee on Bone Metabolism and EFLM Committee on CKDIain Louis Ballantineon September 12, 2026 at 10:00 am September 13, 2026 Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-0904. Online ahead of print. NO ABSTRACT PMID:42730723 | DOI:10.1515/cclm-2026-0904
Interference by saline-based reconstitution of lyophilized quality control plasma in 75 routine laboratory testsChristoph Buchtaon September 12, 2026 at 10:00 am September 13, 2026 Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1310. Online ahead of print. NO ABSTRACT PMID:42730624 | DOI:10.1515/cclm-2026-1310
Enzyme-free voltammetric sensor for monitoring of creatinine in diabetic patient using sustainable L-cysteine/AuNPs/rGO nanocompositeon September 12, 2026 at 3:40 pm September 12, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Mayuri M. Ghatage, Vishakha S. Parkhe, Sohel B. Shaikh, Tukaram D. Dongale, Arpita Pandey-Tiwari
Alternative futures for laboratory medicine in 2050: scenarios and signposts for diagnostic capability contractionKoichiro Yujion September 11, 2026 at 10:00 am September 11, 2026 Clin Chem Lab Med. 2026 Sep 14. doi: 10.1515/cclm-2026-1377. Online ahead of print. ABSTRACT INTRODUCTION: Laboratory medicine has begun to describe its own future, and the images it produces are …
Read more An automated method for constructing continuous reference intervals based on real-world data-driven approaches and forming intelligent agentson September 11, 2026 at 12:53 pm September 11, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Yunfeng Wu, Tingting Huang, Shuang Lou, YunJun Mo, Fan Yu, Shichang Zhang, Haihong He
Analytical Pitfalls in Dry and Wet Chemistry Platforms: From a trainee perspectiveon September 11, 2026 at 11:52 am September 11, 2026 Publication date: Available online 10 September 2026 Source: Practical Laboratory Medicine Author(s): Vandana Tiwary, Sibasish Sahoo
Capillary Serum-Based Spectroscopic Signature for Multiple Sclerosis: A Novel Diagnostic Perspectiveon September 11, 2026 at 11:52 am September 11, 2026 Publication date: Available online 10 September 2026 Source: Practical Laboratory Medicine Author(s): Raí S. Santiago, Marcia H.C. Nascimento, Jaya M.C. Araújo, Bruno B. Castrillo, Paula Z.M. Dias, Regina E. Albano, …
Read more Stoichiometric calibration of ceruloplasmin activity with copper enables molar quantification and has implications for the estimation of non-ceruloplasmin-bound copperAlexandra M Kaneon September 11, 2026 at 10:00 am September 11, 2026 Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0510. Online ahead of print. ABSTRACT OBJECTIVES: Ceruloplasmin (Cp) and non-ceruloplasmin-bound copper (NCC) are measured when evaluating liver disease and disorders of …
Read more The Dutch colon cancer screening programme as an example of adopting indirect-outcome-based analytical performance specifications using a virtual analyser conceptMarith Van Schrojenstein Lantmanon September 10, 2026 at 10:00 am September 10, 2026 Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0319. Online ahead of print. ABSTRACT To ensure reported laboratory results are of adequate quality, it is paramount that the set analytical …
Read more Formula-dependent LDL-C threshold classification and reporting uncertainty in the UK BiobankBohao Xueon September 10, 2026 at 10:00 am September 10, 2026 Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0687. Online ahead of print. ABSTRACT OBJECTIVES: Calculated low-density lipoprotein cholesterol (LDL-C) is widely reported, but formula-dependent estimation differences may alter classification …
Read more Bacteriuria screening with the new automated platform AutionMax-AutionEye: when to cultureRosanna Falboon September 10, 2026 at 10:00 am September 10, 2026 Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-0885. Online ahead of print. ABSTRACT OBJECTIVES: Urinary tract infections (UTIs) are very common in clinical practice. Urine culture remains the cornerstone …
Read more Pre-analytical and analytical validation of calcitonin measurement in fine needle aspiration cytology washoutAmber Materon September 10, 2026 at 10:00 am September 10, 2026 Clin Chem Lab Med. 2026 Sep 11. doi: 10.1515/cclm-2026-1057. Online ahead of print. ABSTRACT OBJECTIVES: Current guidelines advise calcitonin measurements in washout from fine needle aspiration cytology (FNAC) upon inconclusive …
Read more Comparative performance of age-continuous and conventional reference intervals in long-term validation: A 10-year health examination cohort study of serum creatinineon September 10, 2026 at 3:02 pm September 10, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Shuling Chi, Chaochao Ma, Xiaoqi Li, Xuehui Gao, Lian Hou, Xiuzhi Guo, Yunyun Fei, Ling Qiu
Response to “comment on ‘what are the correlates of laboratory productivity in clinical laboratories in the Asia Pacific region?’”on September 10, 2026 at 11:55 am September 10, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Tony Badrick, Jeanette Ju Ting Wu, Rebecca Hui Zhang, Wesley Wong
Re-evaluating haemolysis rejection criteria for PT, aPTT, and D-dimer testing: evidence from paired clinical samples on the CN-3000 analyserJirapa Kaewkhruawanon September 9, 2026 at 10:00 am September 9, 2026 Adv Lab Med. 2026 May 14;7(3):179-186. doi: 10.1515/almed-2026-0028. eCollection 2026 Sep. ABSTRACT OBJECTIVES: Haemolysis is the leading preanalytical cause of sample rejection in coagulation testing. This study prospectively evaluated the …
Read more Molecular genetics in laboratory medicine: from foundations to the future of precision diagnosticsGiuseppe Lippion September 9, 2026 at 10:00 am September 9, 2026 Adv Lab Med. 2026 Jul 7;7(3):167-170. doi: 10.1515/almed-2026-0087. eCollection 2026 Sep. NO ABSTRACT PMID:42713577 | PMC:PMC13552802 | DOI:10.1515/almed-2026-0087
When rare diseases do not appear as a single entityIsabel Solareson September 9, 2026 at 10:00 am September 9, 2026 Adv Lab Med. 2026 Jul 16;7(3):234-237. doi: 10.1515/almed-2025-0193. eCollection 2026 Sep. ABSTRACT OBJECTIVES: The coexistence of multisystemic involvement in a young adult raises the need to consider rare metabolic and …
Read more Appearances can be deceptive: acute myeloid leukaemia simulating chronic lymphocytic leukaemiaBeatriz Gómez Horsefieldon September 9, 2026 at 10:00 am September 9, 2026 Adv Lab Med. 2026 May 20;7(3):229-233. doi: 10.1515/almed-2025-0184. eCollection 2026 Sep. ABSTRACT OBJECTIVES: To report a rare case of acute myeloid leukemia (AML) with abnormal chromatin clumping (ACC) in myeloblasts …
Read more Evaluation of LN34 real-time PCR assay for detection of rabies virus in human and animal specimensLonika Lodhaon September 9, 2026 at 10:00 am September 9, 2026 Adv Lab Med. 2026 Jul 7;7(3):222-228. doi: 10.1515/almed-2025-0197. eCollection 2026 Sep. ABSTRACT OBJECTIVES: Rabies, a neglected zoonotic encephalitis caused by lyssaviruses, claims around 59,000 lives annually. PCR-based methods are pivotal …
Read more DIN SPEC 91532: a process-oriented framework for quality assurance in clinical mass spectrometryMichael Vogeseron September 9, 2026 at 10:00 am September 9, 2026 Clin Chem Lab Med. 2026 Sep 10. doi: 10.1515/cclm-2026-0882. Online ahead of print. NO ABSTRACT PMID:42713734 | DOI:10.1515/cclm-2026-0882
Cardiac troponin in pediatric cardiology: toward standardized interpretive frameworks and clinical decision limitsAldo Clericoon September 9, 2026 at 10:00 am September 9, 2026 Clin Chem Lab Med. 2026 Sep 10. doi: 10.1515/cclm-2026-1248. Online ahead of print. NO ABSTRACT PMID:42713656 | DOI:10.1515/cclm-2026-1248
A comparative evaluation of p-tau217 stability in serum and plasma using two validated assaysArthur Guthknechton September 9, 2026 at 10:00 am September 9, 2026 Clin Chem Lab Med. 2026 Sep 10. doi: 10.1515/cclm-2026-1243. Online ahead of print. NO ABSTRACT PMID:42713737 | DOI:10.1515/cclm-2026-1243
Reference values for serum proenkephalin A in a pediatric and young adult cohorton September 9, 2026 at 11:48 am September 9, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Marina Morath, Sven Garbade, Kristina Klingbeil, Philipp Romero, Dominic Lenz, Ulrike Mütze, Stine Christ, Alexander Fichtner, Elena Schnabel-Besson, Georg F. …
Read more Impact of point of care testing in time to treatment decision-making in emergency departments: a systematic reviewValentina Pecoraroon September 8, 2026 at 10:00 am September 8, 2026 Clin Chem Lab Med. 2026 Sep 9. doi: 10.1515/cclm-2026-0604. Online ahead of print. ABSTRACT The main characteristic of point-of-care testing (PoCT) is to provide rapid test results. It remains uncertain …
Read more Navigating the futures of laboratory medicineMario Plebanion September 8, 2026 at 10:00 am September 8, 2026 Clin Chem Lab Med. 2026 Sep 9. doi: 10.1515/cclm-2026-1468. Online ahead of print. NO ABSTRACT PMID:42708888 | DOI:10.1515/cclm-2026-1468
Response to “Quantifying M proteins: an analytical challenge beyond interference”Shanshan Liangon September 8, 2026 at 10:00 am September 8, 2026 Clin Chem Lab Med. 2026 Sep 9. doi: 10.1515/cclm-2026-1419. Online ahead of print. NO ABSTRACT PMID:42708887 | DOI:10.1515/cclm-2026-1419
AWMF Position Statement on the Revision of the EU’s New Legislative Framework regarding the accreditation of medical laboratoriesMichael Vogeseron September 8, 2026 at 10:00 am September 8, 2026 Clin Chem Lab Med. 2026 Sep 9. doi: 10.1515/cclm-2026-0986. Online ahead of print. NO ABSTRACT PMID:42708879 | DOI:10.1515/cclm-2026-0986
Evaluation of the predictive value of sCD200 and sCD200R for disease severity and relapse in myasthenia gravison September 8, 2026 at 12:08 pm September 8, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Yajie Chen, Jinjing Jia, Yang Xu, Yunfei Zhu, Yanzheng Gu, Jingluan Tian, Qun Xue
Correlations between cerebrospinal fluid and plasma levels of GABA, glutamate, dopamine, and related metabolites, and their concentrations across neurological disorderson September 8, 2026 at 12:08 pm September 8, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Yuhang Deng, Wenqing Wu, Sumei Han, Haoqin Jiang, Ming Guan
Translational optical and electrochemical biosensing strategies for liquid biopsy in triple-negative breast Cancer: advances, challenges, and clinical implementationon September 8, 2026 at 12:08 pm September 8, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Karim G. Mohammed, Mohamed Essameldin Abdelgawad, Mohamed S. Attia
Use of toenail clippings to document an anti-doping violation. Evidence after trimetazidine contamination, trimetazidine single administration and trimetazidine therapeutic treatmentPascal Kintzon September 7, 2026 at 10:00 am September 7, 2026 Clin Chem Lab Med. 2026 Sep 8. doi: 10.1515/cclm-2026-1434. Online ahead of print. NO ABSTRACT PMID:42704381 | DOI:10.1515/cclm-2026-1434
Detection of fast angiotensin I degradation samples in LC-MS/MS plasma renin activity assaysClara Wai Shan Loon September 7, 2026 at 10:00 am September 7, 2026 Clin Chem Lab Med. 2026 Sep 8. doi: 10.1515/cclm-2026-0839. Online ahead of print. NO ABSTRACT PMID:42702995 | DOI:10.1515/cclm-2026-0839
Detection of individual false-low total bilirubin results in neonates and young infants using the bilirubin-to-icteric index ratioon September 6, 2026 at 3:03 pm September 6, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Chinelo Nwoke, Rachel L. Griffiths, Steve Harris, Tejas Kalaria
Lipoprotein(a) repeat testing patterns and clinical significance of changes between repeat measurements: a real-world reference change value–based retrospective analysison September 6, 2026 at 3:03 pm September 6, 2026 Publication date: December 2026 Source: Clinical Biochemistry, Volume 146 Author(s): Beyazıt Semih Yeşil, Meltem Boz, Begüm Dokuzağaç, Şeyma Yeşil
Pooling samples for a high-sensitivity cardiac troponin validation may miss an acute phase response interferenceon September 6, 2026 at 10:52 am September 6, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Peter A. Kavsak
Targeted amino acid profiling reveals early metabolic alterations in young-onset type 2 diabetes mellituson September 5, 2026 at 4:09 pm September 5, 2026 Publication date: 15 March 2027 Source: Clinica Chimica Acta, Volume 594 Author(s): Bhanu Prasad Palivela, Vijayasarathy Ketavarapu, Divya Presingu, Keerthi Reddy, Ramunaidu Addipilli, Mitnala Sasikala, Jagadeshwar Reddy Thota
