Clinical Chemistry

Quantification of Proinsulin in Human Plasma by Proteolysis-Aided Peptide Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry

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Clin Chem. 2026 Aug 21:hvag105. doi: 10.1093/clinchem/hvag105. Online ahead of print. ABSTRACT BACKGROUND: Plasma proinsulin concentrations are used to investigate hypoglycemia. They have also been proposed as a marker of β-cell function, particularly as a ratio with C-peptide. Immunoassays remain the primary method for measuring proinsulin despite potential limitations. Mass spectrometry-based assays have been described, … Read more

Extending Quality Control Procedures for Multiplexed Clinical Assays

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Clin Chem. 2026 Aug 21:hvag100. doi: 10.1093/clinchem/hvag100. Online ahead of print. ABSTRACT BACKGROUND: Multiplexed assays, which simultaneously measure many analytes from a single sample, have become increasingly significant for laboratory diagnosis. Many multiplexed assays with application to clinical diagnosis consist of analyte measurements that can fail individually. In these cases, traditional statistical quantitative quality control … Read more

Distinguishing Acute Myocardial Infarction from Other Forms of Cardiac Injury with the Cardiac Troponin Long-T ITC Complex and High-Sensitivity Troponin I and T in Patients with Suspected Acute Coronary Syndrome: MERITnI Substudy

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Clin Chem. 2026 Aug 20:hvag098. doi: 10.1093/clinchem/hvag098. Online ahead of print. ABSTRACT BACKGROUND: We determined whether circulating cardiac troponin I-cardiac troponin T-troponin C (ITC) complex containing long-form cardiac troponin T (long-T ITC) complex and ratios of high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) could differentiate myocardial infarction (MI) from chronic and … Read more

Biological Variation of Adrenal-Related Endocrine Biomarkers Used for Investigation of Secondary Hypertension

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Clin Chem. 2026 Aug 17:hvag076. doi: 10.1093/clinchem/hvag076. Online ahead of print. ABSTRACT BACKGROUND: Adrenal-related biomarkers are central in evaluating endocrine causes of secondary hypertension, but their interpretation is influenced by biological variation (BV). In this study, we aimed to estimate the within-subject (CVI) and between-subject (CVG) BV and derive the reference change values (RCVs), the … Read more

Enriching Microbial Cell-Free DNA in Clinical Metagenomics Using Epigenetic Filters

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Clin Chem. 2026 Aug 5:hvag089. doi: 10.1093/clinchem/hvag089. Online ahead of print. ABSTRACT INTRODUCTION: Noninvasive cell-free DNA (cfDNA) metagenomic sequencing enables hypothesis-free detection of microbial pathogens in patients with suspected infections. However, its clinical sensitivity is often limited by the overwhelming background of host-derived cfDNA, which can obscure low-abundance microbial signals. We developed an epigenetically guided … Read more

APOB to Estimated APOB Ratio for Screening for the APOE2 Genotype

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Clin Chem. 2026 Aug 3:hvag094. doi: 10.1093/clinchem/hvag094. Online ahead of print. ABSTRACT BACKGROUND: Familial dysbetalipoproteinemia (FDB) is a genetic lipoprotein disorder that can develop in patients homozygous for the apolipoprotein 2 (APOE2) genotype (APOE ɛ2/ɛ2). It is associated with decreased clearance of remnant lipoproteins and increased atherosclerotic cardiovascular disease (ASCVD) risk disproportionate to low-density lipoprotein-cholesterol … Read more

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