Clinical Chemistry

Clinical Utility and Diagnostic Performance of (1→3)-β-D-Glucan in Invasive Mycoses

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Clin Chem. 2026 Aug 26:hvag108. doi: 10.1093/clinchem/hvag108. Online ahead of print. ABSTRACT BACKGROUND: The BDG assay is a non-culture-based biomarker widely used in the diagnosis of invasive fungal infections, particularly among immunocompromised patients. Conventional diagnostic methods, including culture and histopathology, are limited by low sensitivity and delayed turnaround times, prompting increased reliance on adjunctive serologic … Read more

Genetic Investigation of X-Linked Defects with Optimized Targeted Long-Read Sequencing

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Clin Chem. 2026 Aug 24:hvag088. doi: 10.1093/clinchem/hvag088. Online ahead of print. ABSTRACT BACKGROUND: X-linked genetic diseases affect males and females through different inheritance patterns influenced by sex, where differential methylation caused by X-chromosome inactivation can present with a range of asymptomatic, mild, and severe symptoms in females. Targeted long-read sequencing (LRS) through adaptive sampling (AS) … Read more

Quantification of Proinsulin in Human Plasma by Proteolysis-Aided Peptide Immunoaffinity-Liquid Chromatography-Tandem Mass Spectrometry

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Clin Chem. 2026 Aug 21:hvag105. doi: 10.1093/clinchem/hvag105. Online ahead of print. ABSTRACT BACKGROUND: Plasma proinsulin concentrations are used to investigate hypoglycemia. They have also been proposed as a marker of β-cell function, particularly as a ratio with C-peptide. Immunoassays remain the primary method for measuring proinsulin despite potential limitations. Mass spectrometry-based assays have been described, … Read more

Extending Quality Control Procedures for Multiplexed Clinical Assays

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Clin Chem. 2026 Aug 21:hvag100. doi: 10.1093/clinchem/hvag100. Online ahead of print. ABSTRACT BACKGROUND: Multiplexed assays, which simultaneously measure many analytes from a single sample, have become increasingly significant for laboratory diagnosis. Many multiplexed assays with application to clinical diagnosis consist of analyte measurements that can fail individually. In these cases, traditional statistical quantitative quality control … Read more

Distinguishing Acute Myocardial Infarction from Other Forms of Cardiac Injury with the Cardiac Troponin Long-T ITC Complex and High-Sensitivity Troponin I and T in Patients with Suspected Acute Coronary Syndrome: MERITnI Substudy

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Clin Chem. 2026 Aug 20:hvag098. doi: 10.1093/clinchem/hvag098. Online ahead of print. ABSTRACT BACKGROUND: We determined whether circulating cardiac troponin I-cardiac troponin T-troponin C (ITC) complex containing long-form cardiac troponin T (long-T ITC) complex and ratios of high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) could differentiate myocardial infarction (MI) from chronic and … Read more

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