Clinical Chemistry

Prognostic Value of Cardiac Myosin Binding Protein C in the General Population: The Akershus Cardiac Examination 1950 Study

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Clin Chem. 2026 Jul 17:hvag082. doi: 10.1093/clinchem/hvag082. Online ahead of print. ABSTRACT BACKGROUND: Cardiac myosin binding protein C (cMyC) is a cardiac-specific biomarker that is released after acute ischemic myocardial injury. Cardiac troponins are established cardiac biomarkers of myocardial injury and provide prognostic information in patients with cardiovascular disease (CVD) and in healthy persons from … Read more

Characterization of the Migration Profile of 36 Therapeutic Monoclonal Antibodies in Serum Protein Electrophoresis and Immunofixation

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Clin Chem. 2026 Jul 15:hvag080. doi: 10.1093/clinchem/hvag080. Online ahead of print. ABSTRACT BACKGROUND: Therapeutic monoclonal antibodies (t-mAbs) are widely used in oncology, hematology, and immune-mediated diseases. Some t-mAbs are detectable by serum protein electrophoresis (SPEP) and immunofixation (IF), potentially mimicking monoclonal gammopathies. Despite widespread use, migration profiles of many t-mAbs remain incompletely described. METHODS: Thirty-six … Read more

Serum Biomarkers for the Non-Invasive Assessment of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): An Update

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Clin Chem. 2026 Jul 10:hvag077. doi: 10.1093/clinchem/hvag077. Online ahead of print. ABSTRACT BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease, represents the leading cause of chronic liver disease globally. The increasing prevalence of the metabolic syndrome has driven a parallel rise in MASLD-related morbidity and mortality. Accurate assessment of … Read more

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research

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Clin Chem. 2026 Jul 4:hvag078. doi: 10.1093/clinchem/hvag078. Online ahead of print. ABSTRACT BACKGROUND: The quantification of plasma glucagon and oxyntomodulin is important in the assessment of α-cell function, which is impaired in patients with diabetes. We aimed to transfer between laboratories a novel assay that uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the sensitive and … Read more

Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer

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Clin Chem. 2026 Jul 1:hvag079. doi: 10.1093/clinchem/hvag079. Online ahead of print. ABSTRACT BACKGROUND: Comprehensive drug testing (CDT) by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is a valuable method for evaluating clinical samples for unknown toxicological agents. However, the sensitivity of CDT methods is generally lower than targeted approaches. A novel MS technology, linear ion trap (LIT)-pulsing, … Read more

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes

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Clin Chem. 2026 Jun 25:hvag067. doi: 10.1093/clinchem/hvag067. Online ahead of print. ABSTRACT BACKGROUND: How changes in hemoglobin A1c (HbA1c) and continuous glucose monitoring (CGM) metrics track together over time is poorly understood, particularly in type 2 diabetes. We investigated the patterns of change in HbA1c and CGM metrics among older adults with type 2 diabetes. … Read more

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