Transferability and Between Laboratory Imprecision of an LC-MS/MS-Based Reference Measurement Procedure for Apolipoproteins

Clin Chem. 2026 Apr 18:hvag020. doi: 10.1093/clinchem/hvag020. Online ahead of print. ABSTRACT BACKGROUND: Apolipoprotein standardization in multiple calibration laboratories requires equivalent results to value assign matrix-based reference and external quality assurance materials. A multiplexed LC-MS/MS-based reference measurement procedure (RMP) has been developed for serum apolipoproteins apo(a), apoA-I, apoB, apoC-I, apoC-II, apoC-III, and apoE. This study … Read more

Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial

Clin Chem. 2026 Apr 10:hvag029. doi: 10.1093/clinchem/hvag029. Online ahead of print. ABSTRACT BACKGROUND: Automated phlebotomy has the potential to improve patient outcomes and address phlebotomist workforce challenges. The Autonomous Blood Drawing Optimization and Performance Testing trial (ADOPT, ClinicalTrials.gov NCT05878483) assesses performance, safety, and patient experience of an autonomous robotic phlebotomy device (ARPD) that utilizes multimodal … Read more

Current and Future Indication for Testing and Use of Cardiac Troponin in Children

Clin Chem. 2026 Mar 27:hvag021. doi: 10.1093/clinchem/hvag021. Online ahead of print. ABSTRACT BACKGROUND: The clinical use and interpretation of cardiac troponins (cTn) in pediatric patients is heterogeneous. CONTENT: This review is based on an appraisal and synthesis of the available literature and discussions between International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical … Read more

Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers

Clin Chem. 2026 Mar 27:hvag018. doi: 10.1093/clinchem/hvag018. Online ahead of print. ABSTRACT BACKGROUND: Bisulfite conversion remains the gold standard method for DNA methylation analysis but has known limitations. Enzymatic conversion has recently been developed and overcomes some of these pitfalls. This study compared both methods by measuring known colorectal cancer (CRC) methylated biomarkers in colorectal … Read more

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