Clinical Chemistry

Highly Accurate Sequencing Methods for Low-Frequency Variant Detection

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Clin Chem. 2026 Jul 29:hvag074. doi: 10.1093/clinchem/hvag074. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing (NGS), also known as massively parallel sequencing, has become an essential tool across many areas of the life sciences, yet its application to low-frequency variant detection remains constrained by intrinsic error rates and the high cost of ultra-deep sequencing. To … Read more

Prognostic Value of Cardiac Myosin Binding Protein C in the General Population: The Akershus Cardiac Examination 1950 Study

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Clin Chem. 2026 Jul 17:hvag082. doi: 10.1093/clinchem/hvag082. Online ahead of print. ABSTRACT BACKGROUND: Cardiac myosin binding protein C (cMyC) is a cardiac-specific biomarker that is released after acute ischemic myocardial injury. Cardiac troponins are established cardiac biomarkers of myocardial injury and provide prognostic information in patients with cardiovascular disease (CVD) and in healthy persons from … Read more

Characterization of the Migration Profile of 36 Therapeutic Monoclonal Antibodies in Serum Protein Electrophoresis and Immunofixation

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Clin Chem. 2026 Jul 15:hvag080. doi: 10.1093/clinchem/hvag080. Online ahead of print. ABSTRACT BACKGROUND: Therapeutic monoclonal antibodies (t-mAbs) are widely used in oncology, hematology, and immune-mediated diseases. Some t-mAbs are detectable by serum protein electrophoresis (SPEP) and immunofixation (IF), potentially mimicking monoclonal gammopathies. Despite widespread use, migration profiles of many t-mAbs remain incompletely described. METHODS: Thirty-six … Read more

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