Clinical Chemistry

Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing

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Clin Chem. 2026 Jun 23:hvag072. doi: 10.1093/clinchem/hvag072. Online ahead of print. ABSTRACT BACKGROUND: Third-generation sequencing (TGS) enables comprehensive detection of rare hemoglobin (Hb) variants due to its long-read capability. However, library preparation is often labor-intensive and time-consuming. This study developed a novel one-step library preparation (OSLP) method for TGS. By integrating barcode sequences into target-specific … Read more

Tumor-Derived HAVCR1 As a Reliable Fluid Biomarker for the Diagnosis of CNS Lymphoma

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Clin Chem. 2026 May 21:hvag036. doi: 10.1093/clinchem/hvag036. Online ahead of print. ABSTRACT BACKGROUND: The early diagnosis of primary CNS lymphoma (PCNSL) is challenging due to its rapid progression and the lack of reliable noninvasive biomarkers. We aimed to identify robust fluid-based biomarkers for PCNSL, with a focus on primary vitreoretinal lymphoma (PVRL), which is a … Read more

Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction

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Clin Chem. 2026 May 15:hvag030. doi: 10.1093/clinchem/hvag030. Online ahead of print. ABSTRACT BACKGROUND: Sex-specific diagnostic thresholds for high-sensitivity cardiac troponin (hs-cTn) assays are recommended by international guidelines for the diagnosis of myocardial infarction (MI). We assessed the performance of sex-specific single-sample rule-out thresholds for identifying low-risk patients in the emergency department. METHODS: The derivation cohort … Read more

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