Clinical Chemistry

A Culture-Free Lipidomics-Based Screening Test for Uropathogens

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Clin Chem. 2026 Mar 5;72(3):381-389. doi: 10.1093/clinchem/hvaf164. ABSTRACT BACKGROUND: A rapid culture-free method is needed to improve diagnostic efficiency and guide timely antimicrobial therapy for urinary tract infections (UTIs). Previously, we utilized the lipidomics-based fast lipid analysis technique (FLAT) to screen for uropathogens by identifying distinctive microbial membrane lipid profiles, specifically lipid A in gram-negative … Read more

A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection

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Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome (chrY), differential methylation, or single-nucleotide polymorphisms (SNPs) face limitations including sex dependency, complex workflows, or the need for parental genotyping. An FF quantification method that … Read more

Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine

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Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To ensure patient safety, laboratory professionals must define appropriate analytical requirements for each measurand, including measurement uncertainty, selectivity, traceability, and robustness. Performance specifications should ensure that … Read more

Cardiac Biomarker Kinetics in Patients after Coronary Artery Bypass Grafting with an Uncomplicated Course

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Clin Chem. 2026 Feb 24:hvag012. doi: 10.1093/clinchem/hvag012. Online ahead of print. ABSTRACT BACKGROUND: The definition of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) remains debated, particularly regarding the use of cardiac troponins vs creatine kinase MB isoform (CK-MB), and biomarker thresholds seem outdated [10×, 35×, or 70× multiples of upper reference limits … Read more

Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets

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Clin Chem. 2026 Feb 23:hvaf192. doi: 10.1093/clinchem/hvaf192. Online ahead of print. ABSTRACT BACKGROUND: Quantum machine learning (QML) is an emerging field that may offer unique advantages over classical machine learning but has not been extensively studied with real-world healthcare data of practical size. This study evaluates the performance of a recently proposed quantum machine learning … Read more

Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility

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Clin Chem. 2026 Feb 19:hvag005. doi: 10.1093/clinchem/hvag005. Online ahead of print. ABSTRACT BACKGROUND: The provision of prenatal genetic screening in 3 core clinical contexts-recessive conditions, aneuploidy, and serological incompatibility-involves multiple tests across reproductive partners. This complexity limits utilization and impairs adherence to guideline-recommended care, particularly in carrier screening, where male partners are frequently not tested … Read more

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