Clinical Chemistry

Clin Chem. 2026 Mar 9:hvag007. doi: 10.1093/clinchem/hvag007. Online ahead of print. ABSTRACT BACKGROUND: DPYD testing can identify patients at risk for severe toxicity when a standard fluoropyrimidine antineoplastic dose is prescribed. Sequencing-based methods detect rare variants, which require classification. METHODS: DPYD sequencing results over a 9-year period through to 2024 were analyzed. The dataset was … Read more

Clin Chem. 2026 Mar 7:hvag010. doi: 10.1093/clinchem/hvag010. Online ahead of print. ABSTRACT BACKGROUND: Accurate descriptions of human genomic variants are crucial for gene-disease association, discovery, and clinical diagnosis. Although standardized genomic nomenclature, expertly curated and promulgated by the Human Genome Variation Society and the International Standing Committee on Human Cytogenomic Nomenclature, is strongly encouraged in … Read more

Clin Chem. 2026 Mar 5;72(3):331-334. doi: 10.1093/clinchem/hvaf131. NO ABSTRACT PMID:41784385 | DOI:10.1093/clinchem/hvaf131

Clin Chem. 2026 Mar 5;72(3):334-335. doi: 10.1093/clinchem/hvaf151. NO ABSTRACT PMID:41784384 | DOI:10.1093/clinchem/hvaf151

Clin Chem. 2026 Mar 5;72(3):424-425. doi: 10.1093/clinchem/hvaf174. NO ABSTRACT PMID:41784383 | DOI:10.1093/clinchem/hvaf174

Clin Chem. 2026 Mar 5;72(3):335-336. doi: 10.1093/clinchem/hvaf179. NO ABSTRACT PMID:41784382 | DOI:10.1093/clinchem/hvaf179

Clin Chem. 2026 Mar 5;72(3):422-423. doi: 10.1093/clinchem/hvaf140. NO ABSTRACT PMID:41784381 | DOI:10.1093/clinchem/hvaf140

Clin Chem. 2026 Mar 5;72(3):381-389. doi: 10.1093/clinchem/hvaf164. ABSTRACT BACKGROUND: A rapid culture-free method is needed to improve diagnostic efficiency and guide timely antimicrobial therapy for urinary tract infections (UTIs). Previously, we utilized the lipidomics-based fast lipid analysis technique (FLAT) to screen for uropathogens by identifying distinctive microbial membrane lipid profiles, specifically lipid A in gram-negative … Read more

Clin Chem. 2026 Feb 27:hvag015. doi: 10.1093/clinchem/hvag015. Online ahead of print. NO ABSTRACT PMID:41758357 | DOI:10.1093/clinchem/hvag015

Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome (chrY), differential methylation, or single-nucleotide polymorphisms (SNPs) face limitations including sex dependency, complex workflows, or the need for parental genotyping. An FF quantification method that … Read more