Clinical Chemistry

Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To ensure patient safety, laboratory professionals must define appropriate analytical requirements for each measurand, including measurement uncertainty, selectivity, traceability, and robustness. Performance specifications should ensure that … Read more

Clin Chem. 2026 Feb 26:hvag003. doi: 10.1093/clinchem/hvag003. Online ahead of print. NO ABSTRACT PMID:41740614 | DOI:10.1093/clinchem/hvag003

Clin Chem. 2026 Feb 24:hvag012. doi: 10.1093/clinchem/hvag012. Online ahead of print. ABSTRACT BACKGROUND: The definition of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) remains debated, particularly regarding the use of cardiac troponins vs creatine kinase MB isoform (CK-MB), and biomarker thresholds seem outdated [10×, 35×, or 70× multiples of upper reference limits … Read more

Clin Chem. 2026 Feb 23:hvaf192. doi: 10.1093/clinchem/hvaf192. Online ahead of print. ABSTRACT BACKGROUND: Quantum machine learning (QML) is an emerging field that may offer unique advantages over classical machine learning but has not been extensively studied with real-world healthcare data of practical size. This study evaluates the performance of a recently proposed quantum machine learning … Read more

Clin Chem. 2026 Feb 23:hvag009. doi: 10.1093/clinchem/hvag009. Online ahead of print. NO ABSTRACT PMID:41725611 | DOI:10.1093/clinchem/hvag009

Clin Chem. 2026 Feb 19:hvag005. doi: 10.1093/clinchem/hvag005. Online ahead of print. ABSTRACT BACKGROUND: The provision of prenatal genetic screening in 3 core clinical contexts-recessive conditions, aneuploidy, and serological incompatibility-involves multiple tests across reproductive partners. This complexity limits utilization and impairs adherence to guideline-recommended care, particularly in carrier screening, where male partners are frequently not tested … Read more

Clin Chem. 2026 Feb 18:hvag013. doi: 10.1093/clinchem/hvag013. Online ahead of print. NO ABSTRACT PMID:41702419 | DOI:10.1093/clinchem/hvag013

Clin Chem. 2026 Feb 18:hvag008. doi: 10.1093/clinchem/hvag008. Online ahead of print. ABSTRACT BACKGROUND: Blood group typing is essential in transfusion medicine, transplantation, and prenatal care. With the elucidation of the molecular genetics underlying blood group antigens, primarily single-nucleotide variants (SNVs), DNA-based genotyping has emerged as a powerful alternative to serological methods, enabling more accurate and … Read more

Clin Chem. 2026 Feb 16:hvag004. doi: 10.1093/clinchem/hvag004. Online ahead of print. ABSTRACT BACKGROUND: Biallelic loss-of-function variants of STRC are a frequent cause of mild to moderate nonsyndromic hearing loss. The high (>98%) sequence homology between STRC and its pseudogene STRCP1 poses a significant challenge for accurate interpretation of STRC variants using standard methods. Although STRC-STRCP1 … Read more

Clin Chem. 2026 Feb 12:hvag006. doi: 10.1093/clinchem/hvag006. Online ahead of print. ABSTRACT BACKGROUND: Feature extraction via manual chart review is often used for both patient care and research, but it is time-intensive and costly. Recent improvements in natural language processing present novel opportunities to perform high-throughput automated feature extraction. Here, we assessed the accuracy of … Read more