Clinical Chemistry

Performance, Safety, and Patient Experience of an Autonomous Robotic Phlebotomy Device: A Multicenter Trial

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Clin Chem. 2026 Apr 10:hvag029. doi: 10.1093/clinchem/hvag029. Online ahead of print. ABSTRACT BACKGROUND: Automated phlebotomy has the potential to improve patient outcomes and address phlebotomist workforce challenges. The Autonomous Blood Drawing Optimization and Performance Testing trial (ADOPT, ClinicalTrials.gov NCT05878483) assesses performance, safety, and patient experience of an autonomous robotic phlebotomy device (ARPD) that utilizes multimodal … Read more

Current and Future Indication for Testing and Use of Cardiac Troponin in Children

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Clin Chem. 2026 Mar 27:hvag021. doi: 10.1093/clinchem/hvag021. Online ahead of print. ABSTRACT BACKGROUND: The clinical use and interpretation of cardiac troponins (cTn) in pediatric patients is heterogeneous. CONTENT: This review is based on an appraisal and synthesis of the available literature and discussions between International Federation of Clinical Chemistry and Laboratory Medicine Committee on Clinical … Read more

Comparing the Efficiency of Bisulfite and Enzymatic DNA Methylation Conversion Methods for Detection of Colorectal Cancer Biomarkers

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Clin Chem. 2026 Mar 27:hvag018. doi: 10.1093/clinchem/hvag018. Online ahead of print. ABSTRACT BACKGROUND: Bisulfite conversion remains the gold standard method for DNA methylation analysis but has known limitations. Enzymatic conversion has recently been developed and overcomes some of these pitfalls. This study compared both methods by measuring known colorectal cancer (CRC) methylated biomarkers in colorectal … Read more

A Comprehensive Analysis of Metrological Traceability Tools for Urine Albumin Measurements

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Clin Chem. 2026 Mar 19:hvag023. doi: 10.1093/clinchem/hvag023. Online ahead of print. ABSTRACT Urine albumin (UA) concentration is a critical biomarker of kidney disease and broad vascular damage, with an important diagnostic and prognostic role. However, nonstandardized UA measurement procedures are still used in medical laboratories. Much progress toward providing tools for standardizing UA measurements has … Read more

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