Journal

Emerging Threat of Xylazine

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Clin Chem. 2025 Nov 11:hvaf147. doi: 10.1093/clinchem/hvaf147. Online ahead of print. ABSTRACT BACKGROUND: The increasing reports of xylazine in clinical and postmortem toxicology necessitate a survey of its clinical impact. This review examines reports of xylazine across the peer-reviewed literature and grey literature (government and public health reports). CONTENT: Before 2005, reports of xylazine abuse … Read more

Prognostic utility of serial procalcitonin measurements in ICU sepsis: a laboratory-led modelling approach in a resource-limited setting procalcitonin modelling for sepsis mortality in a low-resource ICUAaqilah Fataaron November 11, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 12. doi: 10.1515/cclm-2025-0778. Online ahead of print. ABSTRACT OBJECTIVES: Procalcitonin (PCT) is increasingly used to support sepsis diagnosis, but its role in predicting outcomes remains uncertain, particularly in low-resource settings. We evaluated whether single and serial PCT measurements were associated with 28-day mortality in critically ill adults with suspected … Read more

VeRUS: verification of reference intervals based on the uncertainty of samplingMatthias Beckon November 10, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 11. doi: 10.1515/cclm-2025-0728. Online ahead of print. ABSTRACT OBJECTIVES: Laboratories are required to routinely verify reported reference intervals (RIs), but common verification methods like the CLSI-EP28-A3c binomial test are often impractical due to sample collection requirements. Indirect verification methods like equivalence limits (ELs) use routine data from patient care … Read more

Comparison of the cardiac troponin I-cardiac troponin T-troponin C complex and cardiac troponin I and T in distinguishing myocardial infarction using a single sample at presentationLing Lion November 10, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 11. doi: 10.1515/cclm-2025-0385. Online ahead of print. ABSTRACT OBJECTIVES: The potential relationship between cardiac troponin (cTn) composition and etiologies of myocardial injury may provide diagnostic insights for myocardial infarction (MI). We compared the performance of novel ternary cTnI-cTnT-TnC complex (ITC) assays with high-sensitivity (hs)-cTnI and hs-cTnT in differentiating MI … Read more

Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening programJean Dubéon November 9, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0546. Online ahead of print. ABSTRACT OBJECTIVES: Fecal immunochemical tests (FITs) from various manufacturers yield different results, leading to variable positivity rates and clinical performance. These differences can influence the healthcare costs of a colorectal cancer screening program (CRC-SP), specifically when switching among FIT manufacturers. The analytical … Read more

Integrated Genotyping Strategies for Uncovering Detailed Haplotype Structures and Characterization of DMD Duplications

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Clin Chem. 2025 Nov 7:hvaf136. doi: 10.1093/clinchem/hvaf136. Online ahead of print. ABSTRACT BACKGROUND: Duchenne and Becker muscular dystrophies are X-linked neuromuscular disorders caused by mutations in the dystrophin gene (DMD). Duplications account for approximately 10% of pathogenic variants, but their structural complexity and variable clinical impact present significant challenges in pathogenicity interpretation. METHODS: We retrospectively … Read more

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