Journal

Urinary aldosterone and tetrahydroaldosterone by LC-MS/MS with enzymatic hydrolysis: validation and age-stratified reference intervalsIrene Wijbenga-van der Kooion March 1, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2025-1679. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is a common cause of secondary hypertension. To address the specificity limits of immunoassays, we developed and validated an LC-MS/MS method for urinary aldosterone and tetrahydroaldosterone and established method-matched reference intervals for excretion in 24 h urine. … Read more

Machine learning-based integration of antiphospholipid antibodies for predicting pregnancy outcomes in patients with recurrent spontaneous abortion: a multicenter prospective studyXinli Jiangon March 1, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 2. doi: 10.1515/cclm-2026-0088. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPLs) are closely associated with recurrent spontaneous abortion (RSA) and adverse pregnancy outcomes (POs). Non-criteria aPLs may aid in diagnosing seronegative aPL-related RSA, but their limited performance often leads to missed or delayed diagnosis. This study aimed to … Read more

EGFR as a biomarker in colorectal Cancer: An electrochemical biosensing approach​on February 28, 2026 at 2:53 pm

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Publication date: 15 April 2026 Source: Clinica Chimica Acta, Volume 586 Author(s): Mohammed Khaled Bin Break, Rahamat Unissa Syed, Weiam Hussein, Muhammad Nawaz, Randa Abdeen Hussein Abdalla, Nayla Ahmed Mohammed Aboshouk, Teng-Jin Khoo, Hemat A. Elariny, Afrah E. Mohammed, Sahar S. Alghamdi  

A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection

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Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome (chrY), differential methylation, or single-nucleotide polymorphisms (SNPs) face limitations including sex dependency, complex workflows, or the need for parental genotyping. An FF quantification method that … Read more

Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine

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Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To ensure patient safety, laboratory professionals must define appropriate analytical requirements for each measurand, including measurement uncertainty, selectivity, traceability, and robustness. Performance specifications should ensure that … Read more

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