Clinical Chemistry and Laboratory Medicine

A simplified multitarget stool test for colorectal cancer and advanced precancerous lesion detectionShuizhi Xuon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0236. Online ahead of print. ABSTRACT OBJECTIVES: Multitarget stool tests are approved for colorectal cancer (CRC) screening. Here we developed a multitarget stool test based on the fecal immunochemical test (FIT) and two (NDRG4 and SDC2) DNA methylation markers with a simple calling algorithm. METHODS: FIT, quantitative … Read more

Analytical and clinical performance of the Flash10 molecular point-of-care system for detection of influenza A and B virusesSheng Zengon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0093. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the analytical performance and clinical workflow efficiency of the Flash10 molecular point-of-care testing (POCT) system for the detection of influenza A (FluA) and influenza B (FluB) viruses. METHODS: Throat swab specimens from 178 individuals presenting with influenza-like symptoms … Read more

The prevalence and etiology of macro-growth hormone (GH)Hiroshi Ohnoon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0043. Online ahead of print. ABSTRACT OBJECTIVES: Several macro-hormones have been reported to date. Among them, macroprolactinemia is a common cause of hyperprolactinemia. Growth hormone (GH) and prolactin (PRL) are anterior pituitary hormones related by structure and function. The aim of this study was to clarify the … Read more

Next-generation proteomics in medical laboratories: metrologically sound quantitative protein tests vs. innovative and personalized proteome patternsYuri E M van der Burgton April 2, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 3. doi: 10.1515/cclm-2026-0109. Online ahead of print. ABSTRACT In precision medicine protein phenotypes are foreseen that combined with pattern recognition tools exhibit great potential in guaranteeing safe and accurate test results for patient management and intervention. For discovery purposes novel high-throughput technologies have emerged and this has led to … Read more

Comparison of the analytical and clinical performance of three immunoassay platforms for plasma glial fibrillary acidic protein in Alzheimer’s diseaseYifei Wangon April 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 2. doi: 10.1515/cclm-2025-1694. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to compare the analytical and clinical performance of plasma glial fibrillary acidic protein (GFAP) across three immunoassay platforms. METHODS: Plasma GFAP was measured on three immunoassay platforms (Simoa HD-X, Maccura i1000, MS-Fast Pro 160) in 302 participants … Read more

Impact of sample size and data origin on the simulation-based analytical performance specification derivationHikmet Can Çubukçuon March 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 20. doi: 10.1515/cclm-2026-0112. Online ahead of print. ABSTRACT OBJECTIVES: Indirect clinical outcome-based analytical performance specifications (APS) may offer a feasible alternative to direct studies but raise questions regarding data requirements and transferability. This study aimed to determine the minimum sample size for simulation-driven APS and to investigate the impact … Read more

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