Clinical Chemistry and Laboratory Medicine

What matters most: an age-friendly approach to pathology and laboratory medicineMelody Boudreaux Nelsonon July 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 14. doi: 10.1515/cclm-2025-0616. Online ahead of print. ABSTRACT Under the Age-Friendly Health System initiative, “What Matters” is defined as knowing the older adult’s specific health outcome goals and care preferences. This involves multiple settings of care (e.g., hospital, skilled nursing facility, outpatient visits) and can include end-of-life care. However, … Read more

Assessment of 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Spanish cohortRodrigo Cantera Estefaníaon July 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 14. doi: 10.1515/cclm-2025-0508. Online ahead of print. ABSTRACT OBJECTIVES: The 2023 ACR/EULAR criteria aim to improve the classification of antiphospholipid syndrome (APS). This study aims to validate these criteria and compare clinical and laboratory domains between classified and non-classified patients. METHODS: A retrospective cohort study was conducted at the … Read more

Performance of afternoon (16:00 h) serum cortisol for the diagnosis of Cushing’s syndromeHippolyte Dupuison July 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 11. doi: 10.1515/cclm-2025-0133. Online ahead of print. ABSTRACT INTRODUCTION: Late-night salivary cortisol (LNSC), which assesses the loss of the circadian rhythm of cortisol, is one of the first-line tests performed to diagnose Cushing’s syndrome (CS). Unfortunately, access to LNSC is still limited in some institutions. Alternatively, midnight serum cortisol … Read more

A novel immunoprecipitation-based targeted liquid chromatography-tandem mass spectrometry analysis for accurate determination for copeptin in human serumDanni Muon July 9, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 10. doi: 10.1515/cclm-2025-0022. Online ahead of print. ABSTRACT OBJECTIVES: Copeptin, a stable and simple-to-measure surrogate marker for arginine vasopressin (AVP), demonstrates excellent clinical values, particularly in diagnosing polyuria-polydipsia syndromes. However, conventional immunoassay methods are limited and lack comparability. Our aim was to establish a targeted liquid chromatography-tandem mass spectrometry … Read more

Acoustophoresis-based blood sampling and plasma separation for potentially minimizing sampling-related blood lossAmal Nathon July 4, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 7. doi: 10.1515/cclm-2025-0539. Online ahead of print. ABSTRACT OBJECTIVES: Frequent blood sampling in vulnerable patient groups, such as prematurely born infants, can lead to significant blood loss and increased transfusion needs. Current pre-analytical technology requires comparably large blood volumes and leads to discarding of cells. This study investigates a … Read more

Cellular expression of PD-1, PD-L1 and CTLA-4 in patients with JAK2V617F mutated myeloproliferative disordersChristoph Winkleron July 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 3. doi: 10.1515/cclm-2025-0306. Online ahead of print. ABSTRACT OBJECTIVES: The acquired, somatic JAK2V617F mutation is the most common molecular aberration in patients with myeloproliferative neoplasms (MPN) and also significantly involved in the regulation of T cell immunity. PD-1, PD-L1 and CTLA-4 are key immune checkpoint regulators that are elevated … Read more

Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypesYun Wangon June 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 27. doi: 10.1515/cclm-2025-0499. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric complications associated with antiphospholipid antibodies (aPLs). This study aimed to compare the diagnostic performance of six commercial assay systems for detecting aCL and aβ2GPI antibodies. METHODS: Sixty-three APS … Read more

Exploring commutable materials for serum folate measurement: challenges in cross-method harmonizationXiaerbanu Nizhamudingon June 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 26. doi: 10.1515/cclm-2024-1403. Online ahead of print. ABSTRACT OBJECTIVES: Commutability is a critical attribute for reference materials (RMs) employed in standardization and calibration activities, it ensures the accuracy and equivalence of analytical results across heterogeneous measurement systems and laboratories. In the context of folate quantification, commutability holds particular significance, … Read more

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