Publication date: 30 January 2026 Source: Clinica Chimica Acta, Volume 580 Author(s): Kenichi Sakamoto, Ryu Yanagisawa, Shohei Shigeto, Yozo Nakazawa
Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0546. Online ahead of print. ABSTRACT OBJECTIVES: Fecal immunochemical tests (FITs) from various manufacturers yield different results, leading to variable positivity rates and clinical performance. These differences can influence the healthcare costs of a colorectal cancer screening program (CRC-SP), specifically when switching among FIT manufacturers. The analytical … Read more
Clin Chem. 2025 Nov 7:hvaf136. doi: 10.1093/clinchem/hvaf136. Online ahead of print. ABSTRACT BACKGROUND: Duchenne and Becker muscular dystrophies are X-linked neuromuscular disorders caused by mutations in the dystrophin gene (DMD). Duplications account for approximately 10% of pathogenic variants, but their structural complexity and variable clinical impact present significant challenges in pathogenicity interpretation. METHODS: We retrospectively … Read more
Clin Chem. 2025 Nov 6:hvaf142. doi: 10.1093/clinchem/hvaf142. Online ahead of print. ABSTRACT BACKGROUND: NPM1 is a disease-defining gene in the diagnosis of acute myeloid leukemia (AML) and is important for measurable residual disease (MRD) assessment. Over 50 different NPM1 mutations have been described, but only the 3 most common are routinely monitored during follow-up. METHODS: … Read more
Publication date: 15 January 2026 Source: Clinica Chimica Acta, Volume 579 Author(s): Yongqi Liu, Susu Cai, Tingting Zhang, Xujing Kong, Jianfeng Zhou, Baorong Chen, Zenghe Li
Publication date: Available online 7 November 2025 Source: Practical Laboratory Medicine Author(s): Yiting Tang, Xiang Wu, Huating Zhang, Liu Dong, Ruoshui Cao, Jian Chen, Jiajun Zhu, Lianlong Hu, Qingyu Zhou, Jianming Zhou, Ke Qian, Yong Lin, Shuying Chen
Publication date: 15 January 2026 Source: Clinica Chimica Acta, Volume 579 Author(s): Alicia Madurga, María Sanz-Felisi, Ariadna Arbiol-Roca, Paula Sánchez-García
Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1192. Online ahead of print. NO ABSTRACT PMID:41202177 | DOI:10.1515/cclm-2025-1192
Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1052. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid glucuronide (MPAG). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was … Read more
Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0867. Online ahead of print. ABSTRACT OBJECTIVES: Calcitonin (CT) is the established biomarker for medullary thyroid carcinoma (MTC), but its measurement is hampered by analytical limitations. Procalcitonin (PCT) and pro-gastrin-releasing peptide (ProGRP) have been proposed as alternative or complementary markers, yet the diagnostic value of ProGRP remains … Read more
