Journal

Calculation of reference intervals using an indirect approach from laboratory database​Victor Martin-Rieraon March 19, 2026 at 10:00 am

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Adv Lab Med. 2026 Feb 9;7(1):34-42. doi: 10.1515/almed-2025-0088. eCollection 2026 Mar. ABSTRACT OBJECTIVES: The establishment of reference intervals (RIs) for biochemical parameters is crucial for the accurate interpretation of laboratory test results and clinical decision-making. This study aims to evaluate the feasibility of determining RIs using an indirect approach, which analyzes routine clinical samples instead … Read more

Laboratory based quantitative scoring system for pre-analytical quality indicators in arterial blood gas analysis​Tushar Sethion March 19, 2026 at 10:00 am

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Adv Lab Med. 2025 Dec 5;7(1):26-33. doi: 10.1515/almed-2025-0179. eCollection 2026 Mar. ABSTRACT OBJECTIVES: Arterial blood gas (ABG) analysis is vital in emergency care setting for assessing respiratory and metabolic status, but its reliability is highly jeopardized by pre-analytical errors, which constitute up to 70 % of laboratory errors. This study evaluated pre-analytical quality indicators (QIs) … Read more

Urine pH and ammonium paediatric reference intervals in first morning spot urine​Lucas Ramón Díaz-Anadónon March 19, 2026 at 10:00 am

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Adv Lab Med. 2025 Sep 3;7(1):64-67. doi: 10.1515/almed-2025-0070. eCollection 2026 Mar. ABSTRACT OBJECTIVES: Urinary acidification plays a crucial role in acid-base homeostasis, its evaluation being necessary in the differential diagnosis of metabolic acidosis. The practical limitations of the functional tests required to confirm an acidification disorder point out the need for a simple screening method … Read more

Association between HLA alleles and adverse drug reactions. Mechanisms involved​Ana de Malet Pintos-Fonsecaon March 19, 2026 at 10:00 am

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Adv Lab Med. 2025 Sep 5;7(1):1-9. doi: 10.1515/almed-2025-0118. eCollection 2026 Mar. ABSTRACT INTRODUCTION: Adverse drug reactions (ADRs) represent a major public health problem. A significant subset of these reactions, particularly delayed-type hypersensitivity reactions and severe cutaneous adverse reactions (SCARs), show a strong association with specific alleles of the human major histocompatibility complex (HLA). The following … Read more

S100B urine levels are gestational age, birthweight, delivery mode and gender-dependent in healthy newbornsEbe D’Adamoon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2025-1526. Online ahead of print. ABSTRACT OBJECTIVES: The inclusion of neurobiomarkers (NB) into routine clinical practice remains an unresolved challenge. Among the actions recommended by leading international institutions, a key priority is the establishment of reference curves during the perinatal period. The aim of the study was … Read more

Establishing the laboratory error database: rationale, methodology, and a practical exampleHikmet Can Çubukçuon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0174. Online ahead of print. ABSTRACT Laboratory errors represent a critical yet underestimated threat to patient safety, with 26-30 % of reported errors adversely affecting patient care. Despite extensive scientific literature, no sustainable, open-access platform exists that allows laboratory professionals to rapidly access comprehensive information on error … Read more

Diagnostic accuracy of TIMP-2 and IGFBP7 for detecting acute kidney injury in adult intensive care unit patients: a systematic review and meta-analysisThais F Comizon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0234. Online ahead of print. ABSTRACT Acute kidney injury (AKI) is a frequent complication in hospitalized patients, particularly those admitted to the intensive care unit (ICU), which leads to high rates of morbidity and mortality. Under these conditions, tissue inhibitor metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein … Read more

Unity among the units – a position paper by the DGKLRalf Junkeron March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 18. doi: 10.1515/cclm-2026-0075. Online ahead of print. ABSTRACT More than 30 years after German reunification, the units of measurement used for laboratory medical parameters still differ between eastern and western Germany. While the eastern German states predominantly use “SI” units, “conventional” units are common in medical facilities in the … Read more

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