A large-scale survey on the knowledge, attitude, and practice of patient-based real-time quality control in China​​on November 14, 2025 at 1:46 pm

Publication date: January 2026 Source: Clinical Biochemistry, Volume 141 Author(s): Dong Leng, Mengxue Lyu, Li Wei, Xueling Shang, Xia Lou, Minglong Zhang, Yali Zhou, Tony Badrick, Rui Zhou, On behalf of the APFCB Working Group on Patient-based Real-Time Quality Control

Evaluation of an enzymatic one-step assay for Beta-Hydroxybutyrate blood testing on clinical chemistry platforms using HILIC-MS/MS as a non-enzymatic reference method​on November 14, 2025 at 1:46 pm

Publication date: 30 January 2026 Source: Clinica Chimica Acta, Volume 580 Author(s): Max K. Steinbach, Holger Müller, Yanik Reichard, Konstantin Eulberg, Tobias Frömel, Alexandra Lein, Christoph Peter, Kai Prager, Matthias Grimmler  

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

Clin Chem. 2025 Nov 13:hvaf162. doi: 10.1093/clinchem/hvaf162. Online ahead of print. ABSTRACT BACKGROUND: Phosphorylated tau 217 (p-tau217) has emerged as a leading blood-based biomarker for Alzheimer disease (AD). While typically measured in plasma, serum is a widely used matrix in clinical laboratories, yet few p-tau217 assays have been validated for serum. Evaluating serum p-tau217 performance … Read more

Capillary blood in core laboratories: current and future challengesÁlvaro Gonzálezon November 13, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 14. doi: 10.1515/cclm-2025-0888. Online ahead of print. ABSTRACT Capillary blood sampling is gaining recognition as a patient-centered alternative to traditional venipuncture. Its main advantages are that it is less invasive, reduces patient discomfort, and potentially can be performed without the direct supervision of a healthcare professional. These features could … Read more

Per Se Driving Under the Influence of Cannabis Statutes and Blood Delta-9-Tetrahydrocannabinol Concentrations following Short-Term Cannabis Abstinence

Clin Chem. 2025 Nov 12:hvaf121. doi: 10.1093/clinchem/hvaf121. Online ahead of print. ABSTRACT BACKGROUND: Several US states have per se laws using 2 or 5 ng/mL of delta-9-tetrahydrocannabinol (THC) as cutpoints for driving under the influence of cannabis, while some have zero-tolerance statutes. These cutpoints are considered prima facia evidence of driving impairment. METHODS: In a … Read more

Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home samplingLiesl Heughebaerton November 12, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 13. doi: 10.1515/cclm-2025-1002. Online ahead of print. ABSTRACT OBJECTIVES: As (a lack of) vitamin D has been linked to a wide variety of chronic diseases, there is growing interest in generating robust epidemiological data. Consequently, the need for large-scale biological sample collection has increased. In this context, dried blood … Read more

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