Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Litao Zhang, Chenbin Zhang, Xin Shu, Jiajia Zhu, Hui Wang, Ting Deng, Yisha Jing, Haiyan Liu, Zhenlu Zhang
Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1155. Online ahead of print. ABSTRACT OBJECTIVES: 5α-dihydrotestosterone (DHT) is a potent androgen, related to male sexual development and irreversibly synthesized from testosterone via 5α-reductase. Dysfunctions in the 5α-reductase system, locally or globally, can have substantial health impacts; measurement of both DHT levels and the testosterone-DHT ratio … Read more
Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Jillian Kodger, Thomas J.S. Durant, Nalan Yurtsever, Joe M. El-Khoury
Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1225. Online ahead of print. ABSTRACT OBJECTIVES: This study aims to explore the biological variability of calcium homeostasis biomarkers, including calcium, phosphate, magnesium, 25-OH vitamin D, 1,25-OH vitamin D, and parathyroid hormone (PTH), and to develop a model that predicts PTH concentrations based on these parameters. METHODS: … Read more
Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1371. Online ahead of print. ABSTRACT OBJECTIVES: Voriconazole is an antifungal agent measured in serum and plasma for therapeutic drug monitoring. This study aimed to develop a robust isotope-dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) reference measurement procedure (RMP) to ensure accurate and reliable quantification in compliance with … Read more
Publication date: Available online 22 January 2026 Source: Clinical Biochemistry Author(s): R. Addesso, S. Sarpa, M. Ferrandino, C. Giorgione, A. Marrone, M. Savoia, G. Castaldo
Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-0994. Online ahead of print. ABSTRACT OBJECTIVES: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers substantial analytical advantages over traditional immunoassay methods, including greater specificity and robustness. Conventional LC-MS/MS methods are labor-intensive, requiring highly trained, dedicated laboratory staff. The Cobas® i 601 analyzer (Roche Diagnostics International Ltd., Rotkreuz, Switzerland) … Read more
Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Shu-Mei Bai, Xu-Xiao Guo, Guo-Ming Zhang
Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Obaid Afzal, Pavan Goud, Kavita Goyal, Ali Altharawi, Mubarak A. Alamri, Manal A. Alossaimi, Abdulmalik S.A. Altamimi, Surya Nath Pandey
Clin Chem Lab Med. 2026 Jan 22. doi: 10.1515/cclm-2025-1156. Online ahead of print. ABSTRACT OBJECTIVES: Dehydroepiandrosterone (DHEA) is a steroid prohormone and important precursor for estrogen and testosterone biosynthesis. For differential diagnosis of sexual development disorders (e.g., polycystic ovary syndrome, congenital adrenal hyperplasia), accurate measurement of DHEA in clinical testing is essential. To address that … Read more
