Clinical Chemistry

A Comprehensive Analysis of Metrological Traceability Tools for Urine Albumin Measurements

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Clin Chem. 2026 Mar 19:hvag023. doi: 10.1093/clinchem/hvag023. Online ahead of print. ABSTRACT Urine albumin (UA) concentration is a critical biomarker of kidney disease and broad vascular damage, with an important diagnostic and prognostic role. However, nonstandardized UA measurement procedures are still used in medical laboratories. Much progress toward providing tools for standardizing UA measurements has … Read more

DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping

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Clin Chem. 2026 Mar 9:hvag007. doi: 10.1093/clinchem/hvag007. Online ahead of print. ABSTRACT BACKGROUND: DPYD testing can identify patients at risk for severe toxicity when a standard fluoropyrimidine antineoplastic dose is prescribed. Sequencing-based methods detect rare variants, which require classification. METHODS: DPYD sequencing results over a 9-year period through to 2024 were analyzed. The dataset was … Read more

Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions

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Clin Chem. 2026 Mar 7:hvag010. doi: 10.1093/clinchem/hvag010. Online ahead of print. ABSTRACT BACKGROUND: Accurate descriptions of human genomic variants are crucial for gene-disease association, discovery, and clinical diagnosis. Although standardized genomic nomenclature, expertly curated and promulgated by the Human Genome Variation Society and the International Standing Committee on Human Cytogenomic Nomenclature, is strongly encouraged in … Read more

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