Journal

The contribution of IL-10 and IL-6 as potential biomarkers for detecting central nervous system involvement in non-Hodgkin lymphomas​​on November 1, 2025 at 4:21 pm

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Publication date: December 2025 Source: Clinical Biochemistry, Volume 140 Author(s): Elisa Buzzatti, Fabiana Esposito, Maria Morello, Vanessa Rossi, Maria Christina Cox, Ombretta Annibali, Enrico Santinelli, Maria Antonietta Irno-Consalvo, Giovangiacinto Paterno, Lucia Cardillo, Massimiliano Postorino, Adriano Venditti, Maria Ilaria Del Principe

Short- and medium-term pre-analytical stability of human serum insulin-like growth factor-1Jaco C Louwon October 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 31. doi: 10.1515/cclm-2025-0868. Online ahead of print. ABSTRACT OBJECTIVES: Insulin-like growth factor-1 (IGF-1) is a peptide hormone currently lacking data surrounding its pre-analytical stability. This study aimed to investigate the impact of delaying centrifugation and analysis at different storage temperatures on the in vitro stability of IGF-1. METHODS: The … Read more

A robust ddPCR assay for the absolute quantification of miR-192-5p in hepatocellular carcinoma liquid biopsiesXinmiao Liuon October 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 31. doi: 10.1515/cclm-2025-0824. Online ahead of print. ABSTRACT OBJECTIVES: MicroRNA-192-5p, a liver-enriched miRNA downregulated in hepatocellular carcinoma (HCC), is a promising biomarker, but its clinical use is limited by technical challenges in detecting low-abundance plasma miRNAs. This study innovatively uses droplet digital PCR (ddPCR) with locked nucleic acid (LNA)-modified … Read more

A method comparison of the Roche intact PTH method versus the Roche whole PTH (1-84) method: Examining the differences based on eGFR​Byrne E, Twomey PJ, Crowley RK, McKenna MJ, Kilbane M1Department of Clinical Chemistry, 58038St. Vincent’s University Hospital, Dublin, Ireland2Department of Endocrinology, 58038St. Vincent’s University Hospital, Dublin, Irelandon June 24, 2025 at 4:55 am

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Annals of Clinical Biochemistry, Ahead of Print. AimThird-generation whole PTH (1-84) parathyroid hormone (PTH) assays do not recognize the PTH 7-84 fragment whereas second-generation (intact) assays detect both 1-84 and 7-84 PTH fragments. This study aimed to compare the second-generation Roche intact …

Establishment of a reference interval for calculated globulin on the Roche platform​Colleen Flannery, Alison Griffin, John Quinn, Clodagh Loughrey, Shari Srinivasan1Department of Chemical Pathology, 57978Beaumont Hospital, Dublin, Ireland2Department of Haematology, 57978Beaumont Hospital, Dublin, Ireland3School of Medicine, Royal College of Surgeons in Ireland, Dublin, Irelandon July 29, 2025 at 3:41 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundCalculated globulin, based on direct measurement of total protein and albumin, can be a useful addition to the routinely requested liver profile. However, a reference interval, established using CLSI EP28-A3c recommended direct methods, is …

Analysis of first-trimester maternal serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels as a potential non-invasive biomarker for fetal aneuploidy and NTDs​Karthick E, Sathya Selvarajan, Dhivya Senthil Kumar, Sowmya K, Sridharan K S1Department of Biochemistry, 204733Sri Ramachandra Institute of Higher Education and Research, Chennai, India2Clinical Biochemistry and Quality Manager, 653410MGM Healthcare, Chennai, India3Department of Laboratory Medicine, 204733Sri Ramachandra Institute of Higher Education and Research, Chennai, Indiaon July 29, 2025 at 3:40 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesChromosomal abnormalities and congenital anomalies have huge impact on infant mortality and morbidity. The combined incidence affects approximately 1 per 1000 pregnancies. Current diagnostic modalities include ultrasonography and biomarkers like …

The missing piece: Who is responsible for ensuring clinical chemistry assays used in the UK are fit for purpose?​Rachel Marrington, Gordon Sinclair, Finlay MacKenzie1Birmingham Quality (UK NEQAS), University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK24904School of Human Sciences, London Metropolitan University, London, UKon July 29, 2025 at 3:33 am

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Annals of Clinical Biochemistry, Ahead of Print. Over the past 50 years, External Quality Assessment (EQA) Schemes in the UK have changed from being overseen by the Department of Health and Social Security (DHSS) to a self-funding model post-1990, increasing competition among schemes. Despite reforms, …

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