Annals of Clinical Biochemistry

Performance of the Binding Site cerebrospinal fluid kappa free light chains assay​Simon Alfred Handley, Suzanne Barnes, Nicole Jenkins, Troy Wanandy1Biochemistry, Department of Pathology, 34379Royal Hobart Hospital, Hobart, TAS, Australia2College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia3Department of Special Chemistry, Pathwest QE II MC, Nedlands, WA, Australia4Clinical Biochemistry, Alfred Pathology Service, Melbourne, VIC, Australia5Department of Clinical Immunology and Allergy, 34379Royal Hobart Hospital, Hobart, TAS, Australiaon April 12, 2025 at 2:47 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMeasurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative to CSF oligoclonal bands due to its rapid turnaround time and ability to …

Thyroid reference ranges in pregnancy utilizing an Abbott Alinity platform in a multi-ethnic population in the UK​RV Scott, M Abdel-Malek, J Zhu, J Tan, D Thayabaran, R Valaiyapathi, P Padam, E Jackson, SC Barnes, H Fourie, M Al-Memar, C Kyriacou, M Nimura, T Bourne, NG Martin, R Agha-Jaffar, B Jones, B Khoo, TM-M Tan1Department of Endocrinology, 9762Chelsea & Westminster Hospital, London, UK2Department of Metabolism, Digestion and Reproduction, 4615Imperial College London, London, UK3Blood Sciences, North West London Pathology, Charing Cross Hospital, London, UK4Tommy’s National Centre for Miscarriage Research, Queen Charlotte’s and Chelsea Hospital, 4615Imperial College London, London, UK5Department of Development and Regeneration, KU Leuven, Leuven, Belgium6Department of Gynaecology, University Hospital Leuven, Leuven, Belgium7Department of Endocrinology, 8946Imperial College Healthcare NHS Trust, London, UK8Department of Obstetrics and Gynaecology, 8946Imperial College Healthcare NHS Trust, London, UK9Department of Endocrinology, Division of Medicine, University College London, London, UKon March 29, 2025 at 6:01 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMaternal thyroid function significantly affects fetal development. However, thyroid hormone concentrations change dynamically throughout pregnancy rendering non-pregnancy reference ranges inaccurate. We aimed to establish the trimester-, …

A simpler and more sensitive modified catalytic (bleomycin detectable) iron assay​Mohan M Rajapurkar, Banibrata Mukhopadhyay, Suhas S Lele, Sudhir V Shah129025Muljibhai Patel Urological Hospital, Nadiad, India212215University of Arkansas for Medical Sciences, Little Rock, AR, USAon March 14, 2025 at 4:48 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundIron is ubiquitously distributed in biology, only a miniscule amount exists as free is capable of catalysing production of highly toxic reactive hydroxyl radicle. This free iron also called; labile iron, non-transferrin bound iron or catalytic …

Underreporting of synthetic cathinone poisoning with clinical immunoassays: An experimental and observational study​Théo Willeman, Mathis Laudet, Bruno Revol, Coralie Boudin, Hélène Eysseric-Guerin, Virginie Scolan, Françoise Stanke-Labesque1Laboratoire de Pharmacologie, Pharmacogénétique et Toxicologie, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France2Clinique de Médecine Légale, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France3CEIP-Addictovigilance, 36724CHU Grenoble Alpes, University Grenoble Alpes, Grenoble, France4Laboratoire HP2 Inserm U1300, 27015University Grenoble Alpes, Grenoble, France5Laboratoire de Médecine Légale, 27015University Grenoble Alpes, Grenoble, Franceon March 22, 2025 at 3:44 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThere is an increasing global concern about the use of synthetic cathinones (SCs). Detecting these drugs in human urine samples can be difficult, particularly in emergency settings. Cross-reactivity has been described for several immunoassays. …

Sigma metrics for assessing the analytical performance of 14 biochemical analytes in Mansoura university children’s hospital laboratories (MUCHLs) using CLIA LIMITS 1988 & 2024​Nada Karam, Reham M El-Farahaty, Abdel- Hady El-Gilany, Nessma A Nosser1Clinical Pathology Department, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypt2Public Health & Preventive Medicine, Faculty of Medicine, 68780Mansoura University, Mansoura, Egypton March 14, 2025 at 4:51 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionAnalytical quality is a crucial prerequisite for best practice in medical laboratory. Six-Sigma Methodology (SM) is a quality measurement tool used to evaluate laboratory performance. This study aims to assess the analytical phase baseline …

Comparison of three blood collection tubes for 16 biochemical analytes and stability assessment of selected analytes: VACUETTE® CAT serum Sep clot activator tube, VACUETTE® LH lithium heparin Sep tube, and VACUETTE® CAT serum fast separator tube​Jong Do Seo, Yeon Jae Lee, Changhee Ha, Ju Hee Choi, Seon-Hyeon Shin, Hye Young Han, Hyun-Joong Kim, Sung Hea Kim, Bum Sung Kim, Hanah Kim, Hee-Won Moon, Mina Hur, Yeo-Min Yun1Department of Laboratory Medicine, 119754Konkuk University Medical Center, Seoul, Korea2Department of Cardiovascular Medicine, 58933Konkuk University School of Medicine, Seoul, Korea3Department of Laboratory Medicine, 58933Konkuk University School of Medicine, Seoul, Koreaon March 25, 2025 at 9:29 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundAnalytical performance of VACUETTE® CAT Serum Fast Separator Tube (SFT; Greiner Bio-One, Austria), recently developed quick-clotting serum separator, was evaluated for correlation and stability, comparing with VACUETTE® CAT Serum Sep Clot …

Decrease in the internal quality control intermediate reproducibility imprecision of Cystatin C results in China in the years from 2014 to 2023​Zhixin Zhang, Jie Zeng, Wei Wang, Yuxuan Du, Shuai Yuan, Na Dong, Chuanbao Zhang, Zhiguo WangNational Center for Clinical Laboratories/Beijing Engineering Research Center of Laboratory Medicine, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, Chinaon March 14, 2025 at 4:39 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesWe evaluated the intermediate reproducibility imprecision of cystatin C results based on internal quality control (IQC) data.MethodsIQC data for cystatin C analyte were collected each year from 2014 to 2023. We used the coefficient of variation (…

Preβ1-high-density lipoprotein binds to TG-rich lipoproteins and its release is impaired in the postprandial state among patients with poorly controlled type 2 diabetes​Yuna Horiuchi, Satoshi Hirayama, Atsushi Hori, Yuri Ichikawa, Satoshi Soda, Utako Seino, Kazumasa Sekihara, Tsuyoshi Ueno, Yoshifumi Fukushima, Katsuo Kubono, Takashi Miida1Department of Clinical Laboratory Technology, 12847Juntendo University Faculty of Medical Science, Urayasu, Japan2Department of Clinical Laboratory Medicine, 12847Juntendo University Graduate School of Medicine, Tokyo, Japan3Health Service Center, Tokyo Gakugei University, Tokyo, Japan4Department of Endocrinology and Metabolism, 26834Niigata City General Hospital, Niigata, Japan5Division of Clinical Laboratory, 679868Misono Hospital, Niigata, Japan6Department of Pharmacology, Faculty of Medicine, 12952University of Miyazaki, Miyazaki, Japanon March 5, 2025 at 2:53 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundAlthough preβ1-high-density lipoprotein (preβ1-HDL) promotes cholesterol efflux, high fasting preβ1-high-density lipoprotein levels after breakfast are reduced in patients with poorly controlled type 2 diabetes.ObjectiveThis study investigated …

Metamizole (dipyrone) as an interferent in biochemical assays​David Ceacero-Marín, Lídia Martínez-Zamorano, Adrían Gisbert-Alonso, Isabel Cachón-Suárez, Karla Gabriela Mendoza-Javier, María José Castro-CastroBiochemistry Core of the Clinical Laboratory, 16383Bellvitge University Hospital, Barcelona, Spainon March 5, 2025 at 2:46 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMetamizole (MMZ), commonly used as an analgesic/antipyretic in countries like Spain, faces restrictions elsewhere due to side effects. Despite this, its frequent use underscores the critical importance of studying its impact on the accuracy of …

Exploratory study on reference intervals of calprotectin and pentraxin 3​Igor Alfirevic, Andrea Saracevic, Helena Cicak, Hrvoje Galic, Vanja Radisic Biljak, Ana-Maria Simundic1University Department of Surgery, University Hospital Sveti Duh, Zagreb, Croatia2Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia3University North, Varazdin, Croatia4Department of Medical Laboratory Diagnostics, University Hospital Sveti Duh, Zagreb, Croatia5Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia6Department of Global Medical and Clinical Affairs, 31310Greiner Bio-One, Kremsmünster, Austria7Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatiaon December 9, 2024 at 10:32 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionThe aim of our study was to determine reference intervals for serum pentraxin 3 and calprotectin, as well as for urine calprotectin according to the CLSI EP28-A3C guidelines for defining, establishing, and verifying reference intervals in the …

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