Annals of Clinical Biochemistry

Performance validation and clinical utility of a smartphone-based colorimetric system for differentiating exudative and transudative pleural effusions and ascites via total protein quantification​Dandan Liang, Yonghua Zhao, Yufei Guo, Ziqi Li, Zehua Yang174648Academy of Medical Sciences, Shanxi Medical University, Jinzhong, Shanxi, China2The First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China3Department of Laboratory, 74648The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, Chinaon May 13, 2026 at 2:24 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundTotal protein (TP) is a key indicator to differentiate between pleural effusion (PE) and ascites as exudate or transudate. Rapid quantification of TP can provide more accurate clinical treatment.ObjectiveThis study developed a smartphone-based …

Effects of preanalytical factors on serum vitamin B12 test results​Tuba Batur, Ragıp Balahoroğlu, Hatice Karaoglan, Serap Sezer1Department of Medical Biochemistry, Mardin Training and Research Hospital, Mardin, Turkey2604030Department of Medical Biochemistry, Beyhekim Training and Research Hospital, Konya, Turkey3604030Department of Internal Medicine, Beyhekim Training and Research Hospital, Konya, Turkeyon May 9, 2026 at 1:01 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionWhile conclusions regarding the effects of serum separator tubes on some laboratory tests have been reached in previous studies, the effects of these tubes on the B12 test have not been adequately investigated. This study aimed to determine …

NT-proBNP and its correlation to left ventricular ejection fraction and heart failure – The DEMONSTRATE database​Morgan Lundgren, Peter Ridefelt, Maria K Svensson, Emil Hagström, Thomas Cars, Anders Larsson1Department of Medical Sciences, Clinical Chemistry, 59592Uppsala University, Uppsala, Sweden2Department of Medical Sciences, Renal Medicine, 59592Uppsala University, Uppsala, Sweden3Uppsala Clinical Research Centre, Uppsala, Sweden4Department of Medical Sciences, Cardiology, 83048Uppsala University, Uppsala, Sweden5Sence Research AB, Uppsala, Swedenon November 17, 2025 at 5:23 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundMeasurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) are used in diagnosing heart failure (HF). The main aim was to explore the correlation between NT-proBNP and LVEF.MethodsPatient …

In-vitro verification of tolerance limits for biotin interference of routine biochemistry and immunology assays​Kirsty Swallow, Graeme Wild, Ravishankar SargurImmunology Department and Protein Reference Unit, Northern General Hospital, Sheffield, UKon March 25, 2026 at 1:17 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBiotin is commonly used in many commercial assays. It is known that exogenous biotin can interfere with these tests, however, not all manufacturers have issued warnings or reassurances. Interference can lead to increased or decreased …

Exploring the stability of whole blood samples for remote health care applications towards reliable home-based blood testing​M. H. Elise van Driel, Alan Han, Dirk J. Grünhagen, Christian Ramakers1Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands,2Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlandson February 3, 2026 at 1:41 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesTo evaluate the stability of commonly used biomarkers in whole blood under various storage conditions, in order to assess their suitability for home-based blood collection in remote care settings.MethodsWhole blood samples were stored at 4–8°C, …

Predicting the outcome of short Synacthen test based on baseline cortisol levels: A single-centered retrospective cohort study at a tertiary care hospital in Sri Lanka​Premadasa T, Samarathunga EPA, Sujith EM, Shameela NMF, Basnayaka BMKS, Antonypillai CN, Jayawardana RDP1Department of Chemical Pathology, National Hospital, Kandy, Sri Lanka2Department of Quality Control, National Hospital, Kandy, Sri Lanka3Department of Diabetic and Endocrinology, National Hospital, Kandy, Sri Lankaon September 16, 2025 at 2:39 am

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Annals of Clinical Biochemistry, Ahead of Print. IntroductionShort Synacthen Test (SST), a standard diagnostic test to confirm Adrenal insufficiency (AI), involves substantial expenses.ObjectivesThis study aimed to assess the predictive value of baseline Cortisol levels for SST outcomes and establish …

Evaluation of a point of care prostate-specific antigen blood test on a mobile outreach service​Masood Moghul, Helen Berry, Freeda Millet, Amina Tran, Fiona Mutch, Elizabeth Westaway, Fionnuala Croft, Robyn Shea, Netty Kinsella, Patrick Kierkegaard, Declan Cahill, Nicholas David James1Department of Urology, 4970The Royal Marsden NHS Foundation Trust, London, UK2Division of Radiotherapy and Imaging, 5053The Institute of Cancer Research, London, UK3Cancer Research UK Convergence Science Centre, 4615Imperial College London, London, UKon November 5, 2025 at 10:16 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundPoint of care (POC) tests may improve accessibility and reduce costs of blood tests including in prostate cancer. The Man Van project was a pilot designed to address health inequalities that affect prostate cancer with novel community-based …

Improving the PLASMIC score with the use of RDW-SD in the differential diagnosis for thrombotic thrombocytopenic purpura in Chinese patients​Chi Zhang, Libo Xia, Xuesong Lv, Weixun Sun, Zhigang Xiong, Yang Fei1Department of Laboratory Medicine, 66375Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China2Department of Clinical Laboratory, Changyang Tujia Autonomous County People’s Hospital, Yichang, Chinaon December 15, 2025 at 5:42 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundThis study aimed to identify laboratory parameters that could optimize the PLASMIC score, thereby improving its diagnostic accuracy for thrombotic thrombocytopenic purpura (TTP).MethodsWe performed a retrospective analysis of 136 patients with …

A UK & Ireland national audit of urine acidification​Emma Hughes, Louise Ward, Wassif S Wassif1Department of Clinical Biochemistry, 59633Aberdeen Royal Infirmary, Aberdeen, UK2On Behalf of the Association for Laboratory Medicine, National Clinical Biochemistry Audit Committee, London, UK3Department of Clinical Biochemistry, 575329Bedfordshire Hospitals NHS Foundation Trust, Bedford, UKon December 15, 2025 at 5:41 am

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Annals of Clinical Biochemistry, Ahead of Print. ObjectivesAcidification of urine samples has long been used as a method of preservation to enhance analyte stability. However, there are inherent safety risks to staff and patients when acid preservatives are used. The Association of Laboratory Medicine …

Enhancing laboratory quality through comprehensive risk management and process analysis​Shobha C Ramachandra, Venkatesha Madegowda, Manish Kumar Pandey, Akila Prashant, Kusuma K Shivashankar, Swetha N KempegowdaDepartment of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru, Indiaon February 3, 2026 at 1:34 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundLaboratory test results are crucial for clinical decisions, but errors at any stage can compromise patient safety. Despite technological advances and quality systems, laboratory processes remain vulnerable, necessitating structured risk …

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