Journal
Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer
Clin Chem. 2026 Jul 1:hvag079. doi: 10.1093/clinchem/hvag079. Online ahead of print. ABSTRACT BACKGROUND: Comprehensive drug testing (CDT) by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is a valuable method for evaluating clinical samples for unknown toxicological agents. However, the sensitivity of CDT methods is generally lower than targeted approaches. A novel MS technology, linear ion trap (LIT)-pulsing, … Read more
Emerging blood-based diagnostic strategies for tuberculosisChunlin Yueon July 1, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0123. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global public health challenge. Rapid and accurate diagnostic methods are critical for effective TB control. In recent years, serological diagnosis has attracted growing attention with the continuous identification of novel biomarkers, owing … Read more
Homocitrulline and 3-year mortality in older hospitalised adults: an exploratory studyPeter Noujaimon July 1, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0173. Online ahead of print. ABSTRACT OBJECTIVES: Reliable biomarkers may allow early risk stratification for mortality in older adults. Post-translational modification-derived products (PTMDPs), such as homocitrulline, and the tissue accumulation of advanced glycation end products (AGEs), measured by skin autofluorescence, have been suggested as potential biomarkers of … Read more
Impact of age partitioning on classification discordance in pediatric ferritin reference intervalsDien Minh Tranon June 30, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0785. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate how alternative age-partitioning strategies affect result classification using discrete pediatric ferritin reference intervals (RIs). METHODS: In a prospective cohort of 3,322 apparently healthy individuals aged birth to <19 years, serum ferritin was measured on the Cobas Pro platform. … Read more
National implementation of LOINC: translation methodology and experience from the Polish laboratory terminology standardization projectRafał Świechowskion June 30, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0504. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to present the results of translating the LOINC standard into Polish, summarize key methodological lessons, and outline the current stage of LOINC implementation in Poland. METHODS: Three editions of the LOINC dictionary translation process were conducted using … Read more
Harmonization of measurement units: mission impossible or ethical imperative?Mario Plebanion June 30, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0934. Online ahead of print. ABSTRACT Harmonization initiatives in laboratory medicine have a long history. Nevertheless, despite substantial efforts by international federations, scientific societies, and expert working groups, their implementation and widespread adoption remain incomplete, with many initiatives still at a relatively early stage of development. More … Read more
Analysis of albumin-to-creatinine ratio on automated analysers using a microsampling card (Capitainer DIP70 card) for the collection of urineJohan Olaussonon June 29, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 30. doi: 10.1515/cclm-2026-0034. Online ahead of print. ABSTRACT OBJECTIVES: Albuminuria is a key biomarker of kidney damage, yet preanalytical challenges with conventional liquid urine testing, limiting its utility for decentralized and large-scale screening. This study evaluated the analytical performance of a novel dried urine spot (DUS) device, for measuring … Read more
The laboratory K-curve: bridging diagnostic innovation and adoptionDamien Grusonon June 26, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 29. doi: 10.1515/cclm-2026-0958. Online ahead of print. NO ABSTRACT PMID:42360908 | DOI:10.1515/cclm-2026-0958
The contribution of Laboratory Medicine to Precision NeurologyLorenzo Gaetanion June 26, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 26. doi: 10.1515/cclm-2026-0891. Online ahead of print. NO ABSTRACT PMID:42359687 | DOI:10.1515/cclm-2026-0891