Journal

Distinguishing Acute Myocardial Infarction from Other Forms of Cardiac Injury with the Cardiac Troponin Long-T ITC Complex and High-Sensitivity Troponin I and T in Patients with Suspected Acute Coronary Syndrome: MERITnI Substudy

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Clin Chem. 2026 Aug 20:hvag098. doi: 10.1093/clinchem/hvag098. Online ahead of print. ABSTRACT BACKGROUND: We determined whether circulating cardiac troponin I-cardiac troponin T-troponin C (ITC) complex containing long-form cardiac troponin T (long-T ITC) complex and ratios of high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) could differentiate myocardial infarction (MI) from chronic and … Read more

Interval-specific likelihood ratios improve interpretation of antiphospholipid antibody testing across different analytical platformsJuan Irure-Venturaon August 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0870. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid antibodies (aPL) are essential biomarkers for classification, diagnosis, and risk stratification of antiphospholipid syndrome (APS). Although automated analytical platforms, such as chemiluminescent immunoassay (CLIA), and particle-based multi-analyte technology (PMAT), are increasingly implemented in routine laboratories, uncertainty remains regarding their … Read more

How do pre-barcoded tubes improve preanalytical workflow? A survey studySnežana Jovičićon August 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 21. doi: 10.1515/cclm-2026-0836. Online ahead of print. ABSTRACT OBJECTIVES: Preanalytical errors account for approximately 60-70 % of all laboratory errors, with sample misidentification among the most frequent causes of inaccurate and unreliable test results. Pre-barcoded tubes (PBTs) are collection tubes uniquely identified during manufacturing with machine-readable labels, eliminating the … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of gentamicin in human serumJo Anne Wrighton August 18, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 19. doi: 10.1515/cclm-2026-0593. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of gentamicin is critical to ensure efficacy and minimize toxicity. We report a candidate reference measurement procedure (RMP) to quantify gentamicin in biological matrices, establishing an unbroken traceability chain to the International System of Units (SI). … Read more

Biological Variation of Adrenal-Related Endocrine Biomarkers Used for Investigation of Secondary Hypertension

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Clin Chem. 2026 Aug 17:hvag076. doi: 10.1093/clinchem/hvag076. Online ahead of print. ABSTRACT BACKGROUND: Adrenal-related biomarkers are central in evaluating endocrine causes of secondary hypertension, but their interpretation is influenced by biological variation (BV). In this study, we aimed to estimate the within-subject (CVI) and between-subject (CVG) BV and derive the reference change values (RCVs), the … Read more

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