Current practices and harmonization challenges in Alzheimer’s disease biomarkers: an EFLM Committee: Harmonization SurveyLuisa Agnelloon March 17, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0168. Online ahead of print. ABSTRACT OBJECTIVES: Fluid biomarkers are central to the biological definition and diagnosis of Alzheimer’s disease (AD). Despite international recommendations, substantial variability persists in laboratory practices. This survey, promoted by the Committee: Harmonisation (C:H) of the European Federation of Clinical Chemistry and Laboratory … Read more

Serum as an alternative to plasma for determining the ApoE4 phenotype using Pan-ApoE and ApoE4 chemiluminescent enzyme immunoassaysEric Kortmannon March 17, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0032. Online ahead of print. ABSTRACT OBJECTIVES: Since apolipoprotein E4 (ApoE4) is associated with therapy-related adverse effects of anti-amyloid-β monoclonal antibodies in Alzheimer’s disease, such as amyloid-related imaging abnormalities, methods for determining the ApoE4 status are needed. The Lumipulse® ApoE4 and Pan-ApoE assays provide a practical approach, … Read more

Recommendations for establishing metrological traceability for in vitro diagnostic measurement procedures intended to be used for whole blood samples​on March 17, 2026 at 6:39 pm

Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Jesper V. Johansen, Cas Weykamp, Elizabeth Barczak, Kevin Horan, Sverre Sandberg, Liesbet Deprez, Vincent Delatour, Mauro Panteghini, Neil Greenberg, Jeffrey Budd, Finlay MacKenzie, W. Greg Miller, for the IFCC Working Group on Commutability in Metrological Traceability  

Extracellular vesicles in cardiovascular disease: Biomarkers, therapeutic applications, and drug delivery strategies​on March 17, 2026 at 6:39 pm

Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Qamar Abuhassan, Amirali Salajegheh, Faris Anad Muhammad, Ali Fawzi Al-Hussainy, Tushar B. Gajjar, Malathi Hanumanthayya, Sandeep Kumar Shukla, Rajashree Panigrahi, Neeraj Bainsal, Djamila Polatova, Hayder Naji Sameer, Rasim M. Salih, Mohaned Adil  

Result harmonization in medical laboratories: accomplishments and challengesTony Badrickon March 15, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0323. Online ahead of print. ABSTRACT The Joint Committee for Traceability in Laboratory Medicine (JCTLM) supports worldwide equivalence and comparability of measurement results in laboratory medicine to improve health care and facilitate national and international trade in in vitro diagnostic (IVD) medical devices. The 2025 biennial members … Read more

Point-of-care testing in the era of value-based laboratory medicineMario Plebanion March 14, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0309. Online ahead of print. ABSTRACT Point-of-care testing (POCT) represents a breakthrough technology in laboratory medicine that has expanded rapidly over the past three decades. Today, it accounts for approximately 25 % of all laboratory tests performed worldwide. POCT was initially implemented in critical care settings due … Read more

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