Journal

An improved approach to modelling patient reclassification: HbA1c as an exampleChristopher-John Lancaster Farrellon June 23, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0259. Online ahead of print. ABSTRACT BACKGROUND: External quality assurance (EQA) programs must assess whether the analytical performance of commonly used in vitro diagnostic (IVD) devices is fit for their intended clinical use. We developed a method for this assessment based on reclassification of results at clinical … Read more

Unwarranted variation in total B12 test thresholds for the diagnosis of vitamin B12 deficiency across the UK and the validation of a method-specific total B12 reference interval for the Beckman Coulter DxI platform to support implementation of NICE NG239Emma Stevensonon June 23, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0658. Online ahead of print. ABSTRACT BACKGROUND: Prompt diagnosis and treatment of vitamin B12 deficiency prevents haematological, neurological, psychological and psychiatric disturbances. During November 2024, reference interval data used for the clinical interpretation of total B12 assays was collated from participants of the UK NEQAS for Haematinic … Read more

Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing

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Clin Chem. 2026 Jun 23:hvag072. doi: 10.1093/clinchem/hvag072. Online ahead of print. ABSTRACT BACKGROUND: Third-generation sequencing (TGS) enables comprehensive detection of rare hemoglobin (Hb) variants due to its long-read capability. However, library preparation is often labor-intensive and time-consuming. This study developed a novel one-step library preparation (OSLP) method for TGS. By integrating barcode sequences into target-specific … Read more

A survey of external quality assessment schemes (EQAS) for faecal immunochemical tests for haemoglobin (FIT)​on June 25, 2026 at 12:26 am

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Publication date: 1 January 2027 Source: Clinica Chimica Acta, Volume 592 Author(s): Carolyn Piggott, Marc Thelen, Sam Jones, Petr Kocna, Marieke Frasa, Eline A.E. van der Hagen, Sally C. Benton, on behalf of the International Federation of Clinical Chemistry Faecal Immunochemical Test Working Group (IFCC FIT-WG)  

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