CRISPR-Cas12a/Cas13a in cancer molecular diagnosison March 12, 2026 at 4:52 pm
Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Juncheng Lin, Yuyuan Wang, Biyun Zeng, Zhibing Chen, Xiaocong Lin, Tao Zeng
Journal
A complete blood count-based machine learning model for rapid differentiation of aplastic anemia, immune thrombocytopenia, and myelodysplastic syndromes in routine clinical practiceon March 12, 2026 at 4:52 pm
Publication date: Available online 12 March 2026 Source: Practical Laboratory Medicine Author(s): Xiaohan Wang, Jian Huang, Jingwen Xi, Huan Liu, Yu Yuan
DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping
Clin Chem. 2026 Mar 9:hvag007. doi: 10.1093/clinchem/hvag007. Online ahead of print. ABSTRACT BACKGROUND: DPYD testing can identify patients at risk for severe toxicity when a standard fluoropyrimidine antineoplastic dose is prescribed. Sequencing-based methods detect rare variants, which require classification. METHODS: DPYD sequencing results over a 9-year period through to 2024 were analyzed. The dataset was … Read more
CYFRA 21-1 in lymph node fine-needle aspiration washouts: added value in differentiated thyroid cancerAlfredo Campennion March 11, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0251. Online ahead of print. ABSTRACT OBJECTIVES: Cervical lymph node metastases represent a key challenge in patients with differentiated thyroid carcinoma (DTC). Fine-needle aspiration cytology (FNAC) and thyroglobulin (Tg) measurement in fine-needle washout (FNA-Tg) are widely used but have recognized limitations. Cytokeratin 19 fragment 21-1 measurement in … Read more
Towards the future of Endocrine Laboratory Medicine: defining the role of laboratory medicine specialists to strengthen the clinical-biological partnership – a joint opinion paper of EFLM-C:YS, IFCC TF-YS, and ESE-EYESCharles R Lefèvreon March 11, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0101. Online ahead of print. ABSTRACT Clinical endocrinology relies critically on high-quality biochemical data for diagnosis, therapeutic decisions, and long-term patient monitoring. As endocrine diagnostics grow more complex due to expanding test menus, technological advances, and changing patient populations, the need for a strong, structured partnership between … Read more
An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17-hydroxyprogesterone in human serum and plasmaMartina Bachmannon March 11, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2025-1169. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of 17α-hydroxyprogesterone (17-OHP) in human serum and plasma is required for steroid profiling, to ensure the appropriate diagnosis of congenital adrenal hyperplasia. Therefore, an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) to quantify 17-OHP … Read more
Response to: Be aware of legally required metrology and higher-order reference measurement services run in calibration laboratoriesEmmanuel J Favaloroon March 11, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0328. Online ahead of print. NO ABSTRACT PMID:41808360 | DOI:10.1515/cclm-2026-0328
Comparative Analysis of Diagnostic Kits for Detecting Ureaplasma spp. and M. hominis in Genital and Urinary Sampleson March 12, 2026 at 7:25 am
Publication date: Available online 10 March 2026 Source: Practical Laboratory Medicine Author(s): Juliette Beaucarne, Ivana Buttice, Nada Riahi, Ethel Seyll, Mony Hing, Bram Vanmechelen, Delphine Martiny
Elevated IL-27 and altered anti-inflammatory cytokine levels in SLE patients with end-stage renal diseaseon March 12, 2026 at 7:25 am
Publication date: June 2026 Source: Clinical Biochemistry, Volume 143 Author(s): Paria Bayati, Doaa Hussein Neamah, Yasser Bagheri, Somayeh Sadani, Nikoo Emtiazi, Mohsen Saeidi, Somayeh Ghorbani, Saeid Amirkhanlou
Performance evaluation of automated magnetic beads extraction method for the measurement of 23 plasma steroids using dual liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodon March 12, 2026 at 7:25 am
Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Han Chen, Gang Xu, Mei-juan Zhang, Fu-rong Ying, Hai-xia Huang, He-huan Liu, Jian-rong Yang