Journal

Clin Chem. 2025 Dec 30;72(1):17. doi: 10.1093/clinchem/hvaf139. NO ABSTRACT PMID:41468140 | DOI:10.1093/clinchem/hvaf139

Clin Chem. 2025 Dec 30;72(1):7-10. doi: 10.1093/clinchem/hvaf149. NO ABSTRACT PMID:41468139 | DOI:10.1093/clinchem/hvaf149

Clin Chem. 2025 Dec 30;72(1):133-139. doi: 10.1093/clinchem/hvaf158. ABSTRACT BACKGROUND: Congenital heart defects (CHDs) are the most prevalent birth defects, contributing significantly to infant morbidity and mortality. While genetic factors account for a subset of CHDs, environmental exposures during critical periods of cardiac development are increasingly recognized as potential contributors. CONTENT: This review synthesizes current evidence … Read more

Clin Chem. 2025 Dec 30;72(1):11-15. doi: 10.1093/clinchem/hvaf125. NO ABSTRACT PMID:41468137 | DOI:10.1093/clinchem/hvaf125

Clin Chem. 2025 Dec 30;72(1):123-132. doi: 10.1093/clinchem/hvaf148. ABSTRACT BACKGROUND: Newborn screening (NBS) is a foundational public health program designed to identify severe but treatable conditions in presymptomatic newborns. Since Robert Guthrie introduced the phenylketonuria test in the 1960s, NBS has evolved from single-condition assays to multiplex platforms, enabling early diagnosis, intervention, and long-term follow-up. Understanding … Read more

Clin Chem. 2025 Dec 30;72(1):173-182. doi: 10.1093/clinchem/hvaf159. ABSTRACT BACKGROUND: Congenital cytomegalovirus (cCMV) infection is a leading cause of sensorineural hearing loss in children. Recent evidence that high-dose valacyclovir reduces vertical transmission following primary maternal infection has renewed the urgency for screening. We investigated the utility of quantifying cell-free CMV DNA from noninvasive prenatal screening (NIPS) … Read more

Clin Chem. 2025 Dec 30;72(1):206-216. doi: 10.1093/clinchem/hvaf135. ABSTRACT BACKGROUND: Angiogenic biomarkers aid in short-term prediction of preeclampsia (PE) but are often limited by false-positive results. N-terminal pro-B-type natriuretic peptide (NT-proBNP), which is elevated in PE due to cardiovascular dysfunction, may enhance diagnostic precision. This study evaluated whether adding NT-proBNP to the soluble fms-like tyrosine kinase-1 … Read more

Clin Chem. 2025 Dec 30;72(1):39-46. doi: 10.1093/clinchem/hvaf146. ABSTRACT BACKGROUND: Persistent disparities in prenatal care contribute to preventable maternal and fetal morbidity and mortality, particularly among high-risk and underserved populations. Clinical laboratories play a central role in early detection of prenatal gaps in care and stratifying pregnancy-related risk factors linked to other health conditions, yet their … Read more

Clin Chem. 2025 Dec 30;72(1):82-100. doi: 10.1093/clinchem/hvaf169. ABSTRACT BACKGROUND: Childhood cancer, though rare, remains the leading cause of disease-related death among children in the United States. The overall incidence has been rising for the past several decades, and the factors underlying the increasing rates are unclear. This unexplained increase underscores the critical need for high-quality, … Read more