Journal

Antiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damageAriela Hoxhaon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1565. Online ahead of print. ABSTRACT OBJECTIVES: Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are promising non-criteria aPLs associated with antiphospholipid syndrome (APS) manifestations. Their influence on long-term outcomes and damage remains uncertain. To assess aPS/PT antibodies association with accrual damage and severe APS disease phenotypes, focusing on their potential for … Read more

Discovery of an Artificial Intelligence Label Feedback Loop: How the Success of a Clinically Implemented Artificial Intelligence Algorithm Has Created an Unforeseen Challenge to Algorithm Retraining

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Clin Chem. 2026 Feb 2:hvag001. doi: 10.1093/clinchem/hvag001. Online ahead of print. ABSTRACT BACKGROUND: Artificial intelligence (AI) augmented laboratory tests can improve quality, efficiency, cost-effectiveness, and staff satisfaction. However, the clinical success of these tests can introduce unforeseen challenges for model retraining. This study describes the discovery of an “AI label feedback loop” in a clinically … Read more

Bioequivalence of C-reactive protein in fingerprick blood and serum measured using the point-of-care LumiraDx test for tuberculosis diagnosis in exposed contacts​on February 2, 2026 at 2:00 pm

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Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Arthur M. Chiwaya, Shima M. Abdulgader, Patricia Manjate, James Sserubiri, Bayanda Mdoda, Loide N.N. Shipingana, Dinis Nguenha, Derrick Semugenze, Marc Bañuls, Vinzeigh N. Leukes, Adam Penn-Nicholson, Achilles Katamba, Moses Joloba, Willy Ssengooba, Alberto L. García-Basteiro, Frank Cobelens, Grant Theron  

Laboratory solution to diagnose and monitor atypical IgG4-mediated anti-GBM diseaseJoannes F M Jacobson February 1, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 2. doi: 10.1515/cclm-2025-1499. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing atypical IgG4-mediated anti-glomerular basement membrane (anti-GBM) disease is challenging because conventional serological assays poorly detect IgG4 antibodies. Here we study which commercial assays are affected and we describe proof-of-concept of improved IgG4 anti-GBM detection. METHODS: To investigate the scope … Read more

Antibody response against HERV-K polymerase and envelope by patients with multiple sclerosis​on February 1, 2026 at 1:08 pm

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Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Bruna Reimberg Flose, Kevin Cézar Nascimento Silva, Maria Aparecida Juliano, Virginia Fernandes Moça Trevisani, Carolina Nunes França, Marcelo Andreetta Corral, Luiz Henrique da Silva Nali, Marina Tiemi Shio  

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