Journal

Combined measurement uncertainty of HbA1c and glucose using ISO 20914:2019 and outcome-based simulationEmine Feyza Yurton May 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 15. doi: 10.1515/cclm-2026-0388. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to calculate the measurement uncertainty (MU) of HbA1c and glucose according to ISO/TS 20914:2019 guideline and to evaluate using indirect outcome-based analytical performance specifications (APS). METHODS: MU was estimated using internal quality control data collected between October … Read more

Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practiceHanna De Baetson May 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 14. doi: 10.1515/cclm-2026-0320. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of tacrolimus is essential due to its high inter- and intra-patient variability and narrow therapeutic window. Conventional venous blood sampling may limit sampling frequency and patient convenience. Capillary dried blood spot (DBS) sampling represents a patient-centric … Read more

Optimising newborn screening for galactosaemia: reclassifying GALE and GALM deficiencies as non-target conditions to improve specificityDoris Wongon May 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 14. doi: 10.1515/cclm-2026-0419. Online ahead of print. ABSTRACT OBJECTIVES: Traditionally, neonates were screened for classical galactosaemia in 4 of the 5 jurisdictions in Australia creating inequitable access to early intervention. A push to nationally harmonise newborn bloodspot screening enabled the state of Victoria to proceed with implementation of screening … Read more

The complete blood count: data or clinical information?Mario Plebanion May 12, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 13. doi: 10.1515/cclm-2026-0590. Online ahead of print. ABSTRACT Harmonization in laboratory medicine is increasingly recognized as a fundamental requirement to ensure interchangeable laboratory information, avoid confusion among users, and ultimately improve patient safety. However, current evidence continues to highlight substantial gaps in harmonization across several dimensions of the total … Read more

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