Journal

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research

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Clin Chem. 2026 Jul 4:hvag078. doi: 10.1093/clinchem/hvag078. Online ahead of print. ABSTRACT BACKGROUND: The quantification of plasma glucagon and oxyntomodulin is important in the assessment of α-cell function, which is impaired in patients with diabetes. We aimed to transfer between laboratories a novel assay that uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the sensitive and … Read more

Addressing property and unit discordance in laboratory interoperability: the role of NPU as a governance layerKuenyoul Parkon July 4, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0743. Online ahead of print. ABSTRACT OBJECTIVES: Unified Code for Units of Measure (UCUM) encodes syntax without prescribing which unit should be used. The Nomenclature for Properties and Units (NPU) terminology, developed by IFCC and IUPAC, specifies both the kind-of-quantity (e.g., mass concentration or substance concentration) and … Read more

Ethical evaluation of reflex and reflective testing in conformity with ISO 15189:2022 at the value-based laboratory medicine eraGulsen Yilmazon July 3, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0661. Online ahead of print. ABSTRACT OBJECTIVES: The objective of this study is to evaluate the ethical dimensions of reflex and reflective testing (RRT) within the framework of value-based laboratory medicine and in alignment with ISO 15189:2022. The study aims to highlight the challenges in guiding and … Read more

Glucose-enhanced BISAP score for early prediction of severe acute pancreatitis​Kadir Nıgız Salim Satar Selen Acehan Muge Gulen Sarper Sevdımbas Mehmet Gorur a Ministry of Health Sebinkarahisar State Hospital, Emergency Medicine Clinic, Giresun, Turkeyb Health Sciences University, Adana City Training and Research Hospital, Emergency Medicine Clinic, Adana, Turkeyc Ministry of Health 5 Ocak State Hospital, Emergency Medicine Clinic, Adana, Turkeyon May 11, 2026 at 1:52 am

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Volume 86, Issue 4, JULY 2026, Page 334-343.

Likelihood ratios of quantitative diagnostic test results​Arne Åsberg Gustav Mikkelsen Ann Elisabeth Åsberg Øyvind Skadberg a Department of Medical Biochemistry, Stavanger University Hospital, Stavanger, Norwayb Department of Medical Biochemistry, Trondheim University Hospital, Trondheim, Norwayc Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norwayd Department of pediatrics, Trondheim University Hospital, Trondheim, Norwayon May 14, 2026 at 9:55 am

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Volume 86, Issue 4, JULY 2026, Page 369-373.

Cutoff-dependent test responses and age, sex and seasonal variations of the alcohol biomarkers phosphatidylethanol (PEth) and carbohydrate-deficient transferrin (CDT)​Anders Helander Fredrik Sparring a Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Swedenb Departments of Clinical Chemistry and Clinical Pharmacology, Karolinska University Hospital, Stockholm, Swedenc Avonova Health AB, Skara, Swedenon June 1, 2026 at 8:43 am

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Volume 86, Issue 4, JULY 2026, Page 384-393.

Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer

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Clin Chem. 2026 Jul 1:hvag079. doi: 10.1093/clinchem/hvag079. Online ahead of print. ABSTRACT BACKGROUND: Comprehensive drug testing (CDT) by liquid chromatography-high-resolution mass spectrometry (LC-HRMS) is a valuable method for evaluating clinical samples for unknown toxicological agents. However, the sensitivity of CDT methods is generally lower than targeted approaches. A novel MS technology, linear ion trap (LIT)-pulsing, … Read more

Emerging blood-based diagnostic strategies for tuberculosisChunlin Yueon July 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0123. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global public health challenge. Rapid and accurate diagnostic methods are critical for effective TB control. In recent years, serological diagnosis has attracted growing attention with the continuous identification of novel biomarkers, owing … Read more

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