Journal

Homocitrulline and 3-year mortality in older hospitalised adults: an exploratory studyPeter Noujaimon July 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0173. Online ahead of print. ABSTRACT OBJECTIVES: Reliable biomarkers may allow early risk stratification for mortality in older adults. Post-translational modification-derived products (PTMDPs), such as homocitrulline, and the tissue accumulation of advanced glycation end products (AGEs), measured by skin autofluorescence, have been suggested as potential biomarkers of … Read more

Impact of age partitioning on classification discordance in pediatric ferritin reference intervalsDien Minh Tranon June 30, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0785. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate how alternative age-partitioning strategies affect result classification using discrete pediatric ferritin reference intervals (RIs). METHODS: In a prospective cohort of 3,322 apparently healthy individuals aged birth to <19 years, serum ferritin was measured on the Cobas Pro platform. … Read more

National implementation of LOINC: translation methodology and experience from the Polish laboratory terminology standardization projectRafał Świechowskion June 30, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0504. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to present the results of translating the LOINC standard into Polish, summarize key methodological lessons, and outline the current stage of LOINC implementation in Poland. METHODS: Three editions of the LOINC dictionary translation process were conducted using … Read more

Harmonization of measurement units: mission impossible or ethical imperative?Mario Plebanion June 30, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 1. doi: 10.1515/cclm-2026-0934. Online ahead of print. ABSTRACT Harmonization initiatives in laboratory medicine have a long history. Nevertheless, despite substantial efforts by international federations, scientific societies, and expert working groups, their implementation and widespread adoption remain incomplete, with many initiatives still at a relatively early stage of development. More … Read more

Analysis of albumin-to-creatinine ratio on automated analysers using a microsampling card (Capitainer DIP70 card) for the collection of urineJohan Olaussonon June 29, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 30. doi: 10.1515/cclm-2026-0034. Online ahead of print. ABSTRACT OBJECTIVES: Albuminuria is a key biomarker of kidney damage, yet preanalytical challenges with conventional liquid urine testing, limiting its utility for decentralized and large-scale screening. This study evaluated the analytical performance of a novel dried urine spot (DUS) device, for measuring … Read more

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes

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Clin Chem. 2026 Jun 25:hvag067. doi: 10.1093/clinchem/hvag067. Online ahead of print. ABSTRACT BACKGROUND: How changes in hemoglobin A1c (HbA1c) and continuous glucose monitoring (CGM) metrics track together over time is poorly understood, particularly in type 2 diabetes. We investigated the patterns of change in HbA1c and CGM metrics among older adults with type 2 diabetes. … Read more

New insights in primary aldosteronism diagnosis: a prospective multicenter studyKaijuan Wangon June 25, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 26. doi: 10.1515/cclm-2026-0579. Online ahead of print. ABSTRACT OBJECTIVES: The high variability in screening and confirmatory cut-off values for primary aldosteronism (PA) largely reflects the insufficient standardization of current analytical methods. Competitive and sandwich immunoassays show variable correlation with the reference liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique. This prospective … Read more

The effect of Sebia’s CZE IFCC-converted results on carbohydrate-deficient transferrin (CDT) interpretation in driver’s license assessmentsNathan Debunneon June 25, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 26. doi: 10.1515/cclm-2026-0346. Online ahead of print. ABSTRACT OBJECTIVES: Carbohydrate-deficient transferrin (CDT) is a specific biomarker for chronic excessive alcohol consumption. The IFCC Working Group on CDT Standardization recommends 2-sialo-transferrin (2-sialo-Tf) as the sole measurand, with a decision threshold of 2.0 % CDTIFCC using HPLC. This study evaluates the … Read more

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