Journal

A Culture-Free Lipidomics-Based Screening Test for Uropathogens

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Clin Chem. 2026 Mar 5;72(3):381-389. doi: 10.1093/clinchem/hvaf164. ABSTRACT BACKGROUND: A rapid culture-free method is needed to improve diagnostic efficiency and guide timely antimicrobial therapy for urinary tract infections (UTIs). Previously, we utilized the lipidomics-based fast lipid analysis technique (FLAT) to screen for uropathogens by identifying distinctive microbial membrane lipid profiles, specifically lipid A in gram-negative … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasmaMarie Kubicovaon March 9, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 10. doi: 10.1515/cclm-2025-1366. Online ahead of print. ABSTRACT OBJECTIVES: The quantification of linezolid in serum and plasma matrices is crucial for therapeutic drug monitoring and pharmacokinetic studies. A reference measurement procedure (RMP) was developed and validated to provide accurate, precise, and reliable measurements, fit for its intended use while … Read more

Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care settingPaul Collinsonon March 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2026-0210. Online ahead of print. ABSTRACT A challenge in the implementation of rapid risk-stratification algorithms for patients with suspected acute coronary syndrome is the turnaround time for cardiac troponin (cTn) from blood sampling to reporting of results. Measurement of cTn in whole blood using point of care … Read more

Rare ANA patterns and their clinical correlates: a retrospective large-cohort studyRenren Ouyangon March 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2025-1493. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence and clinical associations of rare HEp 2 indirect immunofluorescence ANA patterns and to evaluate their relationships with disease categories, ANA titers, and expression form. METHODS: We retrospectively analyzed 366,524 ANA tests performed between 2018 and 2024 … Read more

Inosine attenuates glycolysis in erythrocytes via glucose transporter inhibition​Yukio Kume, Motohiro Ohkubo, Naru NaKatuka, Sayaka Aritake-Okada, Naoyuki Yoshikawa, Teruhiko Yoshida, Hideaki Isago, Makoto Kurano1Department of Clinical Laboratory, 719261The University of Tokyo Hospital, Tokyo, Japan2Graduate School of Health and Social Services, Saitama Prefectural University, Saitama, Japan3Department of Clinical Laboratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japanon March 2, 2026 at 11:35 am

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Annals of Clinical Biochemistry, Ahead of Print. BackgroundBlood glucose concentrations decrease after blood collection. We recently developed novel blood collection tubes containing inosine added to sodium fluoride (NaF; FI tubes), which effectively inhibits post-collection blood glucose decline. …

Harnessing the gut–heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategies​on March 9, 2026 at 7:36 pm

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Publication date: 15 May 2026 Source: Clinica Chimica Acta, Volume 587 Author(s): Qhelen Mayline Chandra, Davini Clister, Princella Halim, Aminah Dalimunthe, Muhammad Ichwan, Dina Keumala Sari, Chindy Umaya, Nahida Aktary, Amama Rani, Moon Nyeon Park, Bonglee Kim, Rony Abdi Syahputra  

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