IOF-IFCC international survey of global laboratory practices for bone status indicesEtienne Cavalieron August 6, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0941. Online ahead of print. ABSTRACT OBJECTIVES: Bone status indices (BSIs) are increasingly used in metabolic bone disease, yet global laboratory practices remain poorly characterized. Building on recent IOF-IFCC nomenclature and ESCEO-IOF-IFCC recommendations, we conducted an international descriptive survey of BSI practices. METHODS: A cross-sectional web-based questionnaire … Read more

Sustainability comparison of three clinical laboratory analytical systems in SpainAntonio Fernández Suárezon August 6, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0817. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratories face growing demands to balance healthcare needs with cost and resource efficiency. Solutions that optimise space, cut costs, and minimise water use and waste offer a competitive edge. This study compares water consumption, waste generation, and reagent efficiency … Read more

Unified definition of integrated diagnostics: a position statement of the EFLMJochen K Lennerzon August 6, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0949. Online ahead of print. ABSTRACT Integrated diagnostics is an emerging multidisciplinary model of care that integrates traditionally siloed domains, including pathology, radiology, genomics, and laboratory medicine, into a coordinated framework designed to improve diagnostic accuracy, treatment selection, and clinical outcomes. In this position statement, the EFLM … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of meropenem in human serum and plasmaRupert Schmidon August 5, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Aug 6. doi: 10.1515/cclm-2026-0428. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of meropenem is critical for optimizing clinical efficacy and minimizing toxicity. We describe the validation of an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) candidate reference measurement procedure (RMP) for the quantification of meropenem in human serum … Read more

Enriching Microbial Cell-Free DNA in Clinical Metagenomics Using Epigenetic Filters

Clin Chem. 2026 Aug 5:hvag089. doi: 10.1093/clinchem/hvag089. Online ahead of print. ABSTRACT INTRODUCTION: Noninvasive cell-free DNA (cfDNA) metagenomic sequencing enables hypothesis-free detection of microbial pathogens in patients with suspected infections. However, its clinical sensitivity is often limited by the overwhelming background of host-derived cfDNA, which can obscure low-abundance microbial signals. We developed an epigenetically guided … Read more

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