Journal

Exploring Sex-Specific High-Sensitivity Cardiac Troponin Thresholds for Rule-Out of Non-ST-Elevation Myocardial Infarction

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Clin Chem. 2026 May 15:hvag030. doi: 10.1093/clinchem/hvag030. Online ahead of print. ABSTRACT BACKGROUND: Sex-specific diagnostic thresholds for high-sensitivity cardiac troponin (hs-cTn) assays are recommended by international guidelines for the diagnosis of myocardial infarction (MI). We assessed the performance of sex-specific single-sample rule-out thresholds for identifying low-risk patients in the emergency department. METHODS: The derivation cohort … Read more

First-trimester free thyroxine as an independent predictor of gestational diabetes mellitus: a retrospective cohort study​Thu T T Doon May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Apr 28;7(2):132-139. doi: 10.1515/almed-2026-0007. eCollection 2026 Jun. ABSTRACT OBJECTIVES: Gestational diabetes mellitus (GDM) and thyroid dysfunction are two common endocrine diseases during pregnancy, both of which can adversely affect maternal and fetal health. Numerous studies have shown that abnormalities in thyroid hormones, particularly TSH and FT4, are associated with an increased … Read more

Comparison of capillary and venous hemoglobin determination among school-age children: insights from Zanzibar, Tanzania​Kaunara Azizion May 15, 2026 at 10:00 am

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Adv Lab Med. 2026 Apr 15;7(2):140-147. doi: 10.1515/almed-2025-0053. eCollection 2026 Jun. ABSTRACT OBJECTIVES: There is apprehension regarding the agreement between capillary and venous hemoglobin (Hb) concentrations, which may have far-reaching consequences for global anemia prevalence estimates, heavily dependent on capillary Hb data. METHODS: We investigated the discrepancies in Hb concentrations obtained from venous and capillary … Read more

Comprehensive assessment of innovative immunoassays for the detection of myositis specific antibodiesIvo Rimann-Langejuergenon May 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 15. doi: 10.1515/cclm-2026-0179. Online ahead of print. ABSTRACT OBJECTIVES: Myositis specific antibodies (MSA) are important in the diagnosis of idiopathic inflammatory myopathies (IIM). In addition, several studies have shown clear utility to stratify IIM patients into more homogeneous subsets based on MSA signatures. However, methods for MSA detection show … Read more

Combined measurement uncertainty of HbA1c and glucose using ISO 20914:2019 and outcome-based simulationEmine Feyza Yurton May 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 15. doi: 10.1515/cclm-2026-0388. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to calculate the measurement uncertainty (MU) of HbA1c and glucose according to ISO/TS 20914:2019 guideline and to evaluate using indirect outcome-based analytical performance specifications (APS). METHODS: MU was estimated using internal quality control data collected between October … Read more

Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practiceHanna De Baetson May 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 14. doi: 10.1515/cclm-2026-0320. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of tacrolimus is essential due to its high inter- and intra-patient variability and narrow therapeutic window. Conventional venous blood sampling may limit sampling frequency and patient convenience. Capillary dried blood spot (DBS) sampling represents a patient-centric … Read more

Optimising newborn screening for galactosaemia: reclassifying GALE and GALM deficiencies as non-target conditions to improve specificityDoris Wongon May 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 14. doi: 10.1515/cclm-2026-0419. Online ahead of print. ABSTRACT OBJECTIVES: Traditionally, neonates were screened for classical galactosaemia in 4 of the 5 jurisdictions in Australia creating inequitable access to early intervention. A push to nationally harmonise newborn bloodspot screening enabled the state of Victoria to proceed with implementation of screening … Read more

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