Clinical Chemistry

Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol

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Clin Chem. 2025 Sep 3:hvaf099. doi: 10.1093/clinchem/hvaf099. Online ahead of print. ABSTRACT BACKGROUND: Direct measurement of low-density lipoprotein cholesterol (LDL-C) is widely used and recommended by professional society guidelines despite its potential limitations in patients with hypertriglyceridemia and low LDL-C. This study evaluated the performance of 3 direct LDL-C (LDL-CD) assays, 2 modern LDL-C calculation … Read more

Machine Learning Algorithms for Predicting Urinary Tract Infections: Integration of Demographic Data and Dipstick Reflectance Results

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Clin Chem. 2025 Aug 26:hvaf088. doi: 10.1093/clinchem/hvaf088. Online ahead of print. ABSTRACT BACKGROUND: Urinary tract infections (UTIs) are among the most common infections encountered in healthcare settings. Current diagnostic practices often require 24-48 h due to the time needed for culture results. Given that 70%-80% of cultures return negative, there is significant interest in rapidly … Read more

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