Clinical Chemistry

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

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Clin Chem. 2025 Nov 13:hvaf162. doi: 10.1093/clinchem/hvaf162. Online ahead of print. ABSTRACT BACKGROUND: Phosphorylated tau 217 (p-tau217) has emerged as a leading blood-based biomarker for Alzheimer disease (AD). While typically measured in plasma, serum is a widely used matrix in clinical laboratories, yet few p-tau217 assays have been validated for serum. Evaluating serum p-tau217 performance … Read more

Per Se Driving Under the Influence of Cannabis Statutes and Blood Delta-9-Tetrahydrocannabinol Concentrations following Short-Term Cannabis Abstinence

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Clin Chem. 2025 Nov 12:hvaf121. doi: 10.1093/clinchem/hvaf121. Online ahead of print. ABSTRACT BACKGROUND: Several US states have per se laws using 2 or 5 ng/mL of delta-9-tetrahydrocannabinol (THC) as cutpoints for driving under the influence of cannabis, while some have zero-tolerance statutes. These cutpoints are considered prima facia evidence of driving impairment. METHODS: In a … Read more

Emerging Threat of Xylazine

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Clin Chem. 2025 Nov 11:hvaf147. doi: 10.1093/clinchem/hvaf147. Online ahead of print. ABSTRACT BACKGROUND: The increasing reports of xylazine in clinical and postmortem toxicology necessitate a survey of its clinical impact. This review examines reports of xylazine across the peer-reviewed literature and grey literature (government and public health reports). CONTENT: Before 2005, reports of xylazine abuse … Read more

Integrated Genotyping Strategies for Uncovering Detailed Haplotype Structures and Characterization of DMD Duplications

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Clin Chem. 2025 Nov 7:hvaf136. doi: 10.1093/clinchem/hvaf136. Online ahead of print. ABSTRACT BACKGROUND: Duchenne and Becker muscular dystrophies are X-linked neuromuscular disorders caused by mutations in the dystrophin gene (DMD). Duplications account for approximately 10% of pathogenic variants, but their structural complexity and variable clinical impact present significant challenges in pathogenicity interpretation. METHODS: We retrospectively … Read more

Validation of a Multiplex mRNA- and gDNA-Based Droplet Digital PCR Assay in Acute Myeloid Leukemia Patients with an NPM1 Mutation

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Clin Chem. 2025 Nov 6:hvaf142. doi: 10.1093/clinchem/hvaf142. Online ahead of print. ABSTRACT BACKGROUND: NPM1 is a disease-defining gene in the diagnosis of acute myeloid leukemia (AML) and is important for measurable residual disease (MRD) assessment. Over 50 different NPM1 mutations have been described, but only the 3 most common are routinely monitored during follow-up. METHODS: … Read more

Single Nucleotide Polymorphism Typing Going Spatial: In Situ Padlock Probes Targeting mRNA Variants to Identify Haploidentical Cells within the Tissue Environment

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Clin Chem. 2025 Nov 4:hvaf119. doi: 10.1093/clinchem/hvaf119. Online ahead of print. ABSTRACT BACKGROUND: Despite almost 3 decades of research, the mechanisms underlying the bidirectional trafficking of cells at the maternal-fetal interface that gives rise to microchimerism remain poorly understood. A major barrier to progress has been the lack of suitable detection methods capable of distinguishing … Read more

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