Clinical Chemistry

Clin Chem. 2025 Jul 28:hvaf076. doi: 10.1093/clinchem/hvaf076. Online ahead of print. ABSTRACT BACKGROUND: Confined placental mosaicism can cause false-positive prenatal cell-free DNA (cfDNA) screening results, thereby reducing the positive predictive value (PPV) of the test. We sought to investigate how PPVs for the common fetal trisomies can be refined based on the presence or absence … Read more

Clin Chem. 2025 Jul 25:hvaf080. doi: 10.1093/clinchem/hvaf080. Online ahead of print. ABSTRACT BACKGROUND: Continuous glucose monitors (CGMs) assess interstitial glucose concentrations and improve diabetes management in outpatient settings. However, limited studies have assessed CGM performance in hospitalized pediatric patients, especially at high and low glucose thresholds near clinical decision limits. METHODS: This retrospective study included … Read more

Clin Chem. 2025 Jul 21:hvaf081. doi: 10.1093/clinchem/hvaf081. Online ahead of print. ABSTRACT BACKGROUND: Cell-free fetal DNA (cffDNA) screening exhibits higher sensitivity and lower false-positive rates (FPRs) compared to combined first-trimester screening for common trisomies. However, additional anomalies on other autosomes detected by genome-wide assays cause anxiety and trigger increased rates of amniocentesis. Here, we evaluated … Read more

Clin Chem. 2025 Jul 18:hvaf074. doi: 10.1093/clinchem/hvaf074. Online ahead of print. ABSTRACT BACKGROUND: Iron deficiency (ID) is a prevalent global health issue with a major impact on well-being. Early detection of ID is crucial but challenging due to its nonspecific symptoms and the limitations of traditional diagnostic tests, which are impractical for large-scale screening. This … Read more

Clin Chem. 2025 Jul 15:hvaf077. doi: 10.1093/clinchem/hvaf077. Online ahead of print. ABSTRACT BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays are prone to negative and positive interferences caused by endogenous cardiac troponin-specific autoantibodies (cTnAAbs). Large macrotroponin complexes formed of cardiac troponin (cTn) and cTnAAbs may result in falsely elevated hs-cTn results. This is potentially due to reduced … Read more

Clin Chem. 2025 Jul 9:hvaf073. doi: 10.1093/clinchem/hvaf073. Online ahead of print. ABSTRACT BACKGROUND: Cardiovascular guidelines have long recommended low-density lipoprotein-cholesterol (LDL-C) as the primary target for lipid-lowering therapy. Recent guidelines have emphasized the importance of achieving low LDL-C levels; hence, the accurate measurement of low LDL-C is increasingly clinically relevant. METHODS: Using lipid panel test … Read more

Clin Chem. 2025 Jul 8:hvaf078. doi: 10.1093/clinchem/hvaf078. Online ahead of print. NO ABSTRACT PMID:40626709 | DOI:10.1093/clinchem/hvaf078

Clin Chem. 2025 Jul 4;71(7):737-740. doi: 10.1093/clinchem/hvae223. NO ABSTRACT PMID:40613799 | DOI:10.1093/clinchem/hvae223

Clin Chem. 2025 Jul 4;71(7):821-823. doi: 10.1093/clinchem/hvaf048. NO ABSTRACT PMID:40613798 | DOI:10.1093/clinchem/hvaf048

Clin Chem. 2025 Jul 4;71(7):740-741. doi: 10.1093/clinchem/hvaf010. NO ABSTRACT PMID:40613797 | DOI:10.1093/clinchem/hvaf010