Harnessing Personalized Nutrition and Clinical Chemistry: Opportunities to Improve Public Health

Clin Chem. 2025 Oct 13:hvaf114. doi: 10.1093/clinchem/hvaf114. Online ahead of print. ABSTRACT BACKGROUND: The past 2 decades have seen rapid advances in the development of the concept of personalized nutrition (PN) interventions, and in its application. PN has evolved from attempts to understand the well-recognized interindividual variability in response to dietary intervention that have been … Read more

A New International Patient-Based External Quality Assessment Program to Monitor Harmonization and Standardization Efforts

Clin Chem. 2025 Oct 10:hvaf122. doi: 10.1093/clinchem/hvaf122. Online ahead of print. ABSTRACT BACKGROUND: External quality assessment (EQA) should strive to monitor and reflect variation across laboratories and measuring systems. We introduce a newly developed patient-based EQA program named Noklus Patient Median (NOPAM) that is freely available for the participants. The results from NOPAM enable laboratories … Read more

Quantitative Analysis of a Novel Metabolite Panel to Estimate GFR (Panel eGFR) in Serum and Plasma Using LC-MS/MS

Clin Chem. 2025 Oct 10:hvaf110. doi: 10.1093/clinchem/hvaf110. Online ahead of print. ABSTRACT BACKGROUND: Estimated glomerular filtration rate (eGFR) using creatinine (eGFRcr), cystatin C (eGFRcys), or both (eGFRcr-cys) is not sufficiently accurate in many settings, often due to non-glomerular filtration rate (GFR) determinants of the filtration markers. In principle, using a panel of endogenous markers (panel … Read more

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