Clinical Chemistry

Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring

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Clin Chem. 2025 Dec 19:hvaf156. doi: 10.1093/clinchem/hvaf156. Online ahead of print. ABSTRACT BACKGROUND: The safety and efficacy of fecal microbiota transplantation for prevention of recurrent Clostridioides difficile infection relies on complex interactions between the donor and recipient microbiome. CONTENT: Screening of donor stool has largely aimed to ensure safety; however, metagenomic and metabolic features of … Read more

Association of Serum Uromodulin and Carbamylated Albumin with All-Cause and Cardiovascular Mortality in Patients with No or Mild Chronic Kidney Disease

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Clin Chem. 2025 Dec 16:hvaf166. doi: 10.1093/clinchem/hvaf166. Online ahead of print. ABSTRACT BACKGROUND: Serum uromodulin (SUmod) and carbamylated albumin (C-Alb) are emerging biomarkers for chronic kidney disease (CKD) progression and mortality. SUmod reflects tubular health, while C-Alb is associated with excretory kidney function, CKD progression, and cardiovascular (CV) mortality. We hypothesized that the combined use … Read more

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