Excess Leading to Deficiency: An Unusual Cause of Cytopenia
Clin Chem. 2025 Nov 4;71(11):1105-1108. doi: 10.1093/clinchem/hvaf096. NO ABSTRACT PMID:41184091 | DOI:10.1093/clinchem/hvaf096
Clinical Chemistry
Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making
Clin Chem. 2025 Nov 4;71(11):1178-1179. doi: 10.1093/clinchem/hvaf084. NO ABSTRACT PMID:41184090 | DOI:10.1093/clinchem/hvaf084
Presence of Acicular Crystals in Urine
Clin Chem. 2025 Nov 4;71(11):1176-1177. doi: 10.1093/clinchem/hvaf113. NO ABSTRACT PMID:41184089 | DOI:10.1093/clinchem/hvaf113
Commentary on Excess Leading to Deficiency: An Unusual Cause of Cytopenia
Clin Chem. 2025 Nov 4;71(11):1109. doi: 10.1093/clinchem/hvaf107. NO ABSTRACT PMID:41184088 | DOI:10.1093/clinchem/hvaf107
Commentary on Excess Leading to Deficiency: An Unusual Cause of Cytopenia
Clin Chem. 2025 Nov 4;71(11):1110. doi: 10.1093/clinchem/hvaf108. NO ABSTRACT PMID:41184087 | DOI:10.1093/clinchem/hvaf108
Flow Cytometry in Acute Myeloid Leukemia (AML): A Critical Tool for Accurate Diagnosis, Classification, and Monitoring
Clin Chem. 2025 Oct 23:hvaf111. doi: 10.1093/clinchem/hvaf111. Online ahead of print. ABSTRACT BACKGROUND: Flow cytometry is a crucial diagnostic tool in hematopathology. It supports the identification and follow-up of hematolymphoid neoplasms by providing detailed immunophenotypic data and quantification, and is applicable to various specimen types. CONTENT: Classification and management of acute myeloid leukemia (AML), the … Read more
Challenges in Responding to Cannabis-Impaired Motor Vehicle Drivers
Clin Chem. 2025 Oct 22:hvaf126. doi: 10.1093/clinchem/hvaf126. Online ahead of print. NO ABSTRACT PMID:41124087 | DOI:10.1093/clinchem/hvaf126
Analytical Error of Cardiac Troponin and Impact on the Performance of Accelerated Diagnostic Protocols in Patients with Acute Chest Pain
Clin Chem. 2025 Oct 14:hvaf116. doi: 10.1093/clinchem/hvaf116. Online ahead of print. ABSTRACT BACKGROUND: This study simulates how assay-specific bias influences the diagnostic performance of 0/1-h accelerated diagnostic protocols (ADPs) for 3 different high-sensitivity cardiac troponin (hs-cTn) assays. METHODS: We included 1493 patients presenting with chest pain. hs-cTnT (Roche Diagnostics), hs-cTnI from Abbott Diagnostics (hs-cTnI-A), and … Read more
Regulatory Fragmentation in Europe and Its Risks for Patient Access and Safety: Subcontracting Work Flow Steps of In-House Diagnostic Procedures
Clin Chem. 2025 Oct 14:hvaf123. doi: 10.1093/clinchem/hvaf123. Online ahead of print. ABSTRACT The European Union (EU) In Vitro Diagnostic Regulation (IVDR) imposes stringent obligations on laboratories using in-house in vitro diagnostic devices (IH-IVDs), yet offers limited clarity on whether discrete work flow steps may be subcontracted while maintaining compliance with Article 5(5). This Special Report … Read more
Age-Specific Control and Alzheimer Disease Reference Curves and z-Scores for Glial Fibrillary Acidic Protein in Blood
Clin Chem. 2025 Oct 13:hvaf120. doi: 10.1093/clinchem/hvaf120. Online ahead of print. ABSTRACT BACKGROUND: Serum glial fibrillary acidic protein (GFAP) is a biomarker for astrocytic injury and astrogliosis. Concentrations are elevated in numerous neurological disorders, including a pronounced increase in Alzheimer disease (AD). However, GFAP levels in the serum also increase with age. Consequently, the integration … Read more