Clinical Chemistry and Laboratory Medicine

Comprehensive assessment of medical laboratory performance: a 4D model of quality, economics, velocity, and productivity indicatorsPavel S Zubanovon May 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0323. Online ahead of print. ABSTRACT Laboratory diagnostics play a crucial role in modern medicine and healthcare economics. The effective management of a medical laboratory is based on reliable assessment of indicators characterizing quality of testing, productivity, velocity (speed) and cost-effectiveness. The usual concepts of laboratory management … Read more

Pre-analytical phase errors constitute the vast majority of errors in clinical laboratory testingYanchun Linon May 1, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0190. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory errors pose a threat to patient safety and previous studies have demonstrated that pre-analytical error is the most common error type. Our study aimed to determine the types and frequency of errors occurring in clinical laboratory testing in … Read more

Promising protein biomarkers for early gastric cancer: clinical performance of combined detectionWeifeng Shenon April 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2024-1510. Online ahead of print. ABSTRACT OBJECTIVES: In the early stage of gastric cancer (GC), identifying cancer-specific biomarkers is a key step in the disease screening process. This study aims to explore the clinical value of five novel protein biomarkers and their combination (5 MP) for GC … Read more

Beyond the Hydrashift assay: the utility of isoelectric focusing for therapeutic antibody and paraprotein detectionRieke Reiteron April 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0352. Online ahead of print. ABSTRACT OBJECTIVES: In serum immunofixation electrophoresis, therapeutic monoclonal antibodies (tmAbs) can be misinterpreted as paraproteins. Strategies to circumvent these interferences include the use of anti-tmAb antibodies, which led to the development of the Hydrashift assay. However, this assay is exclusively available for … Read more

Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practicesWeiyan Zhouon April 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0186. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) is critical for optimizing antipsychotic therapy, yet inter-laboratory comparability in China remains poor. Unstandardized practices risk suboptimal dosing and adverse effects, highlighting the need for standardization. This study evaluated TDM practices for six antipsychotics (olanzapine, clozapine, … Read more

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