Clinical Chemistry and Laboratory Medicine

High myoglobin plasma samples risk being reported as falsely low due to antigen excess – follow up after a 2-year period of using a mitigating procedureAnders O Olssonon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0409. Online ahead of print. ABSTRACT OBJECTIVES: Antigen excess (AE) or high dose hook-effect can seriously affect the reported concentration of an analyte, which may impact clinical decisions. This study analyze to what extent the Roche Elecsys® Myoglobin assay is affected by antigen excess and how this … Read more

Practical handling of hemolytic, icteric and lipemic samples for coagulation testing in European laboratories. A collaborative survey from the European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM)Ann Helen Kristoffersenon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0319. Online ahead of print. ABSTRACT OBJECTIVES: Coagulation test results may be affected by hemolysis, icterus and/or lipemia (HIL). Detailed guidelines for HIL-management are missing, both for manual and automatic HIL-checks. The aim of this survey was to provide an overview of the practical procedures for the … Read more

Diagnostic performance of morphological analysis and red blood cell parameter-based algorithms in the routine laboratory screening of heterozygous haemoglobinopathiesGermain Simonon May 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 22. doi: 10.1515/cclm-2025-0210. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study was to carry out a cross-analysis of the morphological abnormalities (MA) and the electrophoretic profile (EP) of blood samples suspect for heterozygous haemoglobinopathies (HTZ HGP). Screening for HTZ HGP was based on erythrocyte parameters provided … Read more

Detecting cardiac injury: the next generation of high-sensitivity cardiac troponins improving diagnostic outcomesGiuseppe Lippion May 4, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0418. Online ahead of print. ABSTRACT Cardiac injury, encompassing a spectrum of heart muscle damage, requires prompt and accurate diagnosis to improve patient outcomes. Early detection using cardiac biomarkers is vital for timely intervention and reducing mortality. This review highlights the role of high-sensitivity cardiac troponins (hs-cTns) … Read more

A value-based score for clinical laboratories: promoting the work of the new EFLM committeeMario Plebanion May 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0490. Online ahead of print. ABSTRACT After the dissemination of a manifesto for the implementation of value-based laboratory medicine (VBLM) and a Strategic Conference dedicated to this issue, a novel initiative of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) is to be initiated with … Read more

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