Clinical Chemistry and Laboratory Medicine

Development of commutable candidate certified reference materials from protein solutions: concept and application to human insulinShiwen Luoon April 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0329. Online ahead of print. ABSTRACT OBJECTIVES: To explore the reasons behind the lack of commutability in protein solution reference materials (RMs) and seeks to eliminate these factors in order to develop commutable reference materials, using human insulin (hINS) as example, to meet the growing demand for … Read more

Biological variation of serum cholinesterase activity in healthy subjectsEmiş Deniz Akbuluton April 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0240. Online ahead of print. ABSTRACT OBJECTIVES: Serum cholinesterase (ChE) 3.1.1.8 is measured to assess exposure to organophosphorus pesticides and determine deficiency related to prolonged apnea after the induction of anesthesia with certain drugs and less often as an indicator of liver function. Biological variation (BV) is … Read more

New insights in preanalytical qualityMario Plebanion April 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0478. Online ahead of print. ABSTRACT The negative impact of preanalytical errors on the quality of laboratory testing is now universally recognized. Nonetheless, recent technological advancements and organizational transformations in healthcare – catalyzed by the still ongoing coronavirus disease 2019 (COVID-19 pandemic) – have introduced new challenges … Read more

Impact of renal function impairment on kappa free light chain indexMartin Schmidaueron April 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0007. Online ahead of print. ABSTRACT OBJECTIVES: To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. METHODS: Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin quotient. Structural equation modeling (SEM) was used to evaluate the direct influence … Read more

Evaluation of error detection and treatment recommendations in nucleic acid test reports using ChatGPT modelsWenzheng Hanon April 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0089. Online ahead of print. ABSTRACT OBJECTIVES: Accurate medical laboratory reports are essential for delivering high-quality healthcare. Recently, advanced artificial intelligence models, such as those in the ChatGPT series, have shown considerable promise in this domain. This study assessed the performance of specific GPT models-namely, 4o, o1, … Read more

The accuracy of presepsin in diagnosing neonatal late-onset sepsis in critically ill neonates: a prospective studyCinzia Aurition April 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0128. Online ahead of print. ABSTRACT OBJECTIVES: The diagnostic accuracy of presepsin (P-SEP) in the newborn is still under evaluation. METHODS: In a multicenter study, we studied the accuracy of P-SEP as a diagnostic marker of late-onset sepsis (LOS) in critical newborns with underlying disorders, to define … Read more

Direct screening and quantification of monoclonal immunoglobulins in serum using MALDI-TOF mass spectrometry without antibody enrichmentHou-Long Luoon April 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 18. doi: 10.1515/cclm-2025-0203. Online ahead of print. ABSTRACT OBJECTIVES: Monoclonal gammopathies (MGs) are characterized by the presence of monoclonal immunoglobulins (M-proteins). Currently, recommendations for screening of MGs primarily rely on nephelometry, turbidimetry and electrophoresis, which have inherent limitations in sensitivity and throughput. This study aimed to evaluate a novel … Read more

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