Clinical Chemistry and Laboratory Medicine

From metabolic profiles to clinical interpretation: multivariate approaches to population-based and personalized reference intervals and reference change valuesAbdurrahman Coskunon August 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0786. Online ahead of print. ABSTRACT Interpretation of laboratory test results is a comparative process that requires reference data. Such data are derived for each analyte separately, without accounting for, the interrelationships among analytes. Physicians use test panels containing multiple analytes to enhance clinical significance and improve … Read more

Comparative analysis of population-based and personalized reference intervals for biochemical markers in peri-menopausal women: population from the PALM cohort studyJiaming Wuon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0658. Online ahead of print. ABSTRACT OBJECTIVES: Significant changes in clinical biochemical markers occur during the peri-menopausal period. Traditional population-based reference intervals (popRIs) may not reflect individual physiological variability, limiting clinical interpretation. This study aimed to establish personalized reference intervals (prRIs) for menopausal women and compare them … Read more

Evaluating large language models as clinical laboratory test recommenders in primary and emergency care: a crucial step in clinical decision makingAhmed Medhat Zayedon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0647. Online ahead of print. ABSTRACT OBJECTIVES: Large language models (LLMs), such as OpenAI’s GPT-4o, have demonstrated considerable promise in transforming clinical decision support systems. In this study, we focused on a single but crucial task of clinical decision-making: laboratory test ordering. METHODS: We evaluated the self-consistency … Read more

The current status of serum insulin measurements and the need for standardizationCurt Rohlfingon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0552. Online ahead of print. ABSTRACT OBJECTIVES: Insulin assays are used to assess insulin resistance and to aid in the diagnosis of conditions such as insulinoma and various forms of hypoglycemia. However, discrepancies among commercial assays limit their clinical and research utility. This study evaluates the current … Read more

Biomarkers in body fluids and their detection techniques for human intestinal permeability assessmentJian Zhangon August 12, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 13. doi: 10.1515/cclm-2025-0318. Online ahead of print. ABSTRACT INTRODUCTION: Intestinal permeability (IP) is a crucial index for intestinal tract integrity, reflecting intestinal barrier function, injury, diseases, and related systemic conditions. However, current mainstream testing methods are invasive and qualitative. Biomarkers for IP in body fluids offer noninvasive and quantitative … Read more

Overview of laboratory diagnostics for immediate management of patients presenting to the emergency department with acute bleedingGiuseppe Lippion August 12, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 13. doi: 10.1515/cclm-2025-0775. Online ahead of print. ABSTRACT Acute, life-threatening bleeding is a relatively common but critical presentation in the emergency department (ED), needing immediate assessment and intervention to reduce morbidity and mortality. Rapid identification of the bleeding source, evaluation of hemostatic function, and timely initiation of resuscitation are … Read more

Challenges of using natriuretic peptides to screen for the risk of developing heart failure in patients with diabetes: a report from the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee on Clinical Applications of Cardiac Bio-Markers (C-CB)Allan S Jaffeon August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0863. Online ahead of print. ABSTRACT BACKGROUND: Several guidelines groups have made recommendations about how to use natriuretic peptides (NPs) to screen patients with diabetes for incipient heart failure. This group is at risk for undetected and stage B heart failure, where structural heart disease is present … Read more

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