Clinical Chemistry and Laboratory Medicine

Assessment of serum free light chain measurements in a large Chinese chronic kidney disease cohort: a multicenter real-world studyXia Luoon April 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2024-1226. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing monoclonal gammopathy in chronic kidney disease (CKD) patients is challenging due to the complex interpretation of serum free light chain (FLC) levels. This study aimed to assess the FLC levels in a large cohort of Chinese CKD patients. METHODS: … Read more

Defining dried blood spot diameter: implications for measurement and specimen rejection ratesNick Flynnon April 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2025-0183. Online ahead of print. ABSTRACT OBJECTIVES: Dried blood spot (DBS) specimen acceptance guidelines recommend rejecting specimens based on DBS size, often expressed as a diameter. Computer vision methods can estimate DBS size from images obtained from standalone equipment, smartphone cameras or existing laboratory instrumentation. However, no … Read more

Clostebol detection after transdermal and transmucosal contact. A systematic reviewVincenzo Giannicola Mendittoon April 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0331. Online ahead of print. ABSTRACT INTRODUCTION: To analyze the available evidence about the correlation between the presence of detectable amounts of clostebol metabolites in urine and the transdermal or transmucosal contact of clostebol. CONTENT: A systematic review was performed. A systematic search was conducted in PubMed/MEDLINE, … Read more

Supporting prioritization efforts of higher-order reference providers using evidence from the Joint Committee for Traceability in Laboratory Medicine databaseMauro Panteghinion April 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0401. Online ahead of print. ABSTRACT The Joint Committee for Traceability in Laboratory Medicine (JCTLM) database represents a valuable resource for implementing metrological traceability in laboratory medicine. Three main database users can be identified: (a) in vitro diagnostic (IVD) manufacturers, using the database information for meeting ISO … Read more

Cell population data for early detection of sepsis in patients with suspected infection in the emergency departmentMarta Cancella De Abreuon April 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0180. Online ahead of print. ABSTRACT OBJECTIVES: Traditional biomarkers used for sepsis diagnosis have limited sensitivity and specificity and, so far, are not recommended for sepsis diagnosis. We aimed to evaluate diagnostic accuracy of XN-9000® hematology analyzer derived cell population data (CPD) for sepsis. METHODS: We conducted … Read more

Clinical vs. statistical significance: considerations for clinical laboratoriesHamit Hakan Alpon April 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2025-0219. Online ahead of print. ABSTRACT Amongst the main perspectives when evaluating the results of medical studies are statistical significance (following formal statistical testing) and clinical significance. While statistical significance shows that a factor’s observed effect on the study results is unlikely (for a given alpha) to … Read more

Liquid chromatography tandem mass spectrometry (LC-MS/MS) candidate reference measurement procedure for urine albuminSeiei Shibaon April 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2024-1374. Online ahead of print. ABSTRACT OBJECTIVES: Urine albumin is a key biomarker utilized for diagnosis and monitoring progression of chronic kidney disease (CKD). These characteristics highlight the importance urine albumin serves in patient management. However, laboratory results are confounded by a lack of standardization where results … Read more

IgA-type macroprolactin among 130 patients with macroprolactinemiaMasayuki Ishiharaon April 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2025-0264. Online ahead of print. ABSTRACT OBJECTIVES: Macroprolactin (macro-PRL) mostly comprises a complex of PRL with IgG. The aim of this study was to clarify whether IgA-type macro-PRL exists and, if so, to elucidate the prevalence of and differences in laboratory data from IgG-type. METHODS: One hundred … Read more

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