Clinical Chemistry and Laboratory Medicine

Acoustophoresis-based blood sampling and plasma separation for potentially minimizing sampling-related blood lossAmal Nathon July 4, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 7. doi: 10.1515/cclm-2025-0539. Online ahead of print. ABSTRACT OBJECTIVES: Frequent blood sampling in vulnerable patient groups, such as prematurely born infants, can lead to significant blood loss and increased transfusion needs. Current pre-analytical technology requires comparably large blood volumes and leads to discarding of cells. This study investigates a … Read more

Cellular expression of PD-1, PD-L1 and CTLA-4 in patients with JAK2V617F mutated myeloproliferative disordersChristoph Winkleron July 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 3. doi: 10.1515/cclm-2025-0306. Online ahead of print. ABSTRACT OBJECTIVES: The acquired, somatic JAK2V617F mutation is the most common molecular aberration in patients with myeloproliferative neoplasms (MPN) and also significantly involved in the regulation of T cell immunity. PD-1, PD-L1 and CTLA-4 are key immune checkpoint regulators that are elevated … Read more

Comprehensive evaluation of antiphospholipid antibody testing methodologies in APS diagnosis: performance comparisons across assay systems and clinical subtypesYun Wangon June 26, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 27. doi: 10.1515/cclm-2025-0499. Online ahead of print. ABSTRACT OBJECTIVES: Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and obstetric complications associated with antiphospholipid antibodies (aPLs). This study aimed to compare the diagnostic performance of six commercial assay systems for detecting aCL and aβ2GPI antibodies. METHODS: Sixty-three APS … Read more

Exploring commutable materials for serum folate measurement: challenges in cross-method harmonizationXiaerbanu Nizhamudingon June 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 26. doi: 10.1515/cclm-2024-1403. Online ahead of print. ABSTRACT OBJECTIVES: Commutability is a critical attribute for reference materials (RMs) employed in standardization and calibration activities, it ensures the accuracy and equivalence of analytical results across heterogeneous measurement systems and laboratories. In the context of folate quantification, commutability holds particular significance, … Read more

Isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedures for the quantification of total and free phenytoin in human serum and plasmaTobias Schierscheron June 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 23. doi: 10.1515/cclm-2024-0858. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) was developed and validated to accurately measure serum and plasma concentrations of total and free phenytoin. METHODS: Quantitative nuclear magnetic resonance spectroscopy (qNMR) was used to determine the … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry based candidate reference measurement procedure for the simultaneous quantification of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum and plasmaKerstin Kandleron June 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 20. doi: 10.1515/cclm-2024-1138. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of 25-hydroxyvitamin D2 (25OHD2) and 25-hydroxyvitamin D3 (25OHD3) in human serum and plasma is presented. METHODS: Quantitative Nuclear Magnetic Resonance (qNMR) spectroscopic methodology has been … Read more

Assessment of atypical cells in detecting bladder cancer in female patientsYan Zhaoon June 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 18. doi: 10.1515/cclm-2025-0268. Online ahead of print. ABSTRACT OBJECTIVES: Atypical or malignant urothelial cells may be identified with a research parameter of atypical cells (Atyp.C) using a fully automated urine particle analyzer in routine urinalysis. This study aimed to determine whether Atyp.C can serve as an effective screening tool … Read more

The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevanceWilson de Melo Cruvinelon June 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 18. doi: 10.1515/cclm-2025-0286. Online ahead of print. ABSTRACT The indirect immunofluorescence assay (IFA) on HEp-2 cells is the prevailing method used to screen for autoantibodies in the investigation of systemic autoimmune diseases (SAID). When positive, the titer provides a semi-quantitative assessment of the autoantibody serum concentration whereas the immunofluorescence … Read more

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