Clinical Chemistry and Laboratory Medicine

Investigation of the possible cause of over-estimation of human aldosterone in plasma, using a unique, non-synthetic human aldosterone-free matrixSheree Stoneron July 31, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 1. doi: 10.1515/cclm-2024-1468. Online ahead of print. ABSTRACT OBJECTIVES: Aldosterone is over-estimated by direct immunoassay when compared to assay by LC-MS/MS. We have investigated the mechanism for this over-estimation, using dichloromethane (DCM) extraction and a unique matrix of non-synthetic aldosterone-free plasma (ALFP). METHODS: Samples used were from patients with … Read more

A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163Victor Bruunon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0653. Online ahead of print. ABSTRACT OBJECTIVES: Hemophagocytic lymphohistiocytosis (HLH) is a severe condition requiring timely diagnosis to initiate immunomodulatory therapy. Soluble interleukin-2 receptor (sIL-2R) and soluble CD163 (sCD163) are biomarkers crucial for making this diagnosis. This study aims to establish pediatric reference intervals (RIs) for serum … Read more

Robustness of steroidomics-based machine learning for diagnosis of primary aldosteronism: a laboratory medicine perspectiveGraeme Eisenhoferon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0200. Online ahead of print. ABSTRACT OBJECTIVES: Use of machine learning (ML) in diagnostics offers promise to optimise interpretation of laboratory data and guide clinical decision-making. For this, ML-based outputs should provide robustly reproducible results at least as good as the underlying laboratory data. The objective of … Read more

Can Theranos resurrect from its ashes?Miyo K Chatanakaon July 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 18. doi: 10.1515/cclm-2025-0651. Online ahead of print. ABSTRACT Theranos was a biotechnology company which, in the 2010s, promised to revolutionize traditional clinical chemistry testing by using novel technology, microvolumes of blood obtained by finger pricks, and performance of tests outside traditional clinical chemistry laboratories, such as in pharmacies. Theranos … Read more

MAGLUMI® Tacrolimus (CLIA) assay: analytical performances and comparison with LC-MS/MS and ARCHITECT Tacrolimus (CMIA) assayMingpeng Fuon July 15, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 16. doi: 10.1515/cclm-2025-0181. Online ahead of print. ABSTRACT OBJECTIVES: Tacrolimus has been a cornerstone of immunosuppressive therapy over the past two decades. Due to its narrow therapeutic window and pharmacokinetic variability, drug monitoring is vital for enhancing the efficacy and safety during therapy. In the present study, we evaluated … Read more

Utilization analysis of laboratory tests using health insurance claims data: advancing nationwide diagnostic stewardship monitoring systemsSe-Eun Kooon July 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 15. doi: 10.1515/cclm-2025-0641. Online ahead of print. ABSTRACT OBJECTIVES: Diagnostic stewardship aims to optimize laboratory testing practices by ensuring appropriate test utilization while minimizing unnecessary testing. However, the nationwide monitoring systems for laboratory test utilization remain underdeveloped. In this study, we analyzed nationwide health insurance claims data to identify … Read more

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