Clinical Chemistry and Laboratory Medicine – Page 26

Implementation of AI systems in the clinical laboratory: insights from an expert survey and recommendations for best practiceHe S Yangon February 3, 2026 at 11:00 am

February 3, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1322. Online ahead of print. ABSTRACT OBJECTIVES: Despite growing interest in artificial intelligence (AI) and machine learning (ML), many laboratory professionals lack experience with developing in-house AI systems or implementing those supplied by external providers. The IFCC Committee on AI in Laboratory Medicine (C-AILM) conducted a survey … Read more

Familial erythrocytosis and phenotypic heterogeneity associated with different defects in alpha globin genes: a significant new case of Hb Wroclaw (α88(F9) Ala>Glu; HBA1: c.266C>A)Valentina Carraion February 2, 2026 at 11:00 am

February 2, 2026 by ccinfoadmin

Clin Chem Lab Med. 2025 Oct 13;64(3):e57-e61. doi: 10.1515/cclm-2025-1118. Print 2026 Feb 24. NO ABSTRACT PMID:41622866 | DOI:10.1515/cclm-2025-1118

Laboratory solution to diagnose and monitor atypical IgG4-mediated anti-GBM diseaseJoannes F M Jacobson February 1, 2026 at 11:00 am

February 1, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Feb 2. doi: 10.1515/cclm-2025-1499. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing atypical IgG4-mediated anti-glomerular basement membrane (anti-GBM) disease is challenging because conventional serological assays poorly detect IgG4 antibodies. Here we study which commercial assays are affected and we describe proof-of-concept of improved IgG4 anti-GBM detection. METHODS: To investigate the scope … Read more

Effect of storage conditions on NSE, S100, and B2M stability in cerebrospinal fluid and serumNatalia García-Sanchaon January 27, 2026 at 11:00 am

January 27, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1320. Online ahead of print. ABSTRACT OBJECTIVES: The reliability of cerebrospinal fluid (CSF) and serum biomarkers depends on sample integrity, which is strongly influenced by storage conditions. While -80 °C is considered the gold standard for long-term preservation, it requires specialized infrastructure, whereas -20 °C is more … Read more

Predicting congenital hypothyroidism in newborns with complex risk profiles by using thyroid-stimulating hormone variations across serial dried blood spotsLaura Cappellettion January 27, 2026 at 11:00 am

January 27, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1387. Online ahead of print. ABSTRACT OBJECTIVES: Newborn screening for congenital hypothyroidism (CH) relies on thyroid-stimulating hormone (TSH) levels from dried blood spots (DBS). We investigated whether incorporating TSH variation across serial DBS could improve prediction of CH in term and preterm infants with complex risk profiles. … Read more

Utility of flow cytometric PAX5 protein detection for the diagnosis of B-cell acute lymphoblastic leukemiaTanintorn Pootrakulon January 27, 2026 at 11:00 am

January 27, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1647. Online ahead of print. ABSTRACT OBJECTIVES: Accurate B-lineage assignment in acute leukemia is critical for therapeutic decisions. While nuclear expression of PAX5 protein (nPAX5) is a highly reliable marker for B-cell differentiation, its conventional assessment by time-consuming immunohistochemistry (IHC) is not ideal for rapid diagnosis. This … Read more

Cardiac troponin T measurement following cardiac surgery in children with congenital heart defects predicts adverse outcomesGiuseppe Isgròon January 27, 2026 at 11:00 am

January 27, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1461. Online ahead of print. ABSTRACT OBJECTIVES: Testing for high-sensitivity cardiac troponin (hs-cTn) often occurs following pediatric cardiac surgery, although evidence regarding its utility remains heterogeneous. This study aimed to assess the prognostic value of postoperative hs-cTnT patterns detected within 48 h after cardiac surgery. METHODS: Serum … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 5-alpha-dihydrotestosterone in human serum and plasmaLea Lewinon January 24, 2026 at 11:00 am

January 24, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1155. Online ahead of print. ABSTRACT OBJECTIVES: 5α-dihydrotestosterone (DHT) is a potent androgen, related to male sexual development and irreversibly synthesized from testosterone via 5α-reductase. Dysfunctions in the 5α-reductase system, locally or globally, can have substantial health impacts; measurement of both DHT levels and the testosterone-DHT ratio … Read more

Biological variation and inter-relation between key calcium homeostasis biomarkersNora Alicia Guldhaugon January 23, 2026 at 11:00 am

January 23, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1225. Online ahead of print. ABSTRACT OBJECTIVES: This study aims to explore the biological variability of calcium homeostasis biomarkers, including calcium, phosphate, magnesium, 25-OH vitamin D, 1,25-OH vitamin D, and parathyroid hormone (PTH), and to develop a model that predicts PTH concentrations based on these parameters. METHODS: … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of voriconazole in human serum and plasmaMarie Kubicovaon January 23, 2026 at 11:00 am

January 23, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jan 26. doi: 10.1515/cclm-2025-1371. Online ahead of print. ABSTRACT OBJECTIVES: Voriconazole is an antifungal agent measured in serum and plasma for therapeutic drug monitoring. This study aimed to develop a robust isotope-dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) reference measurement procedure (RMP) to ensure accurate and reliable quantification in compliance with … Read more