Clinical Chemistry and Laboratory Medicine

ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verificationGunnar Brandhorston October 22, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0637. Online ahead of print. ABSTRACT OBJECTIVES: Reference intervals (RIs) are essential for interpreting laboratory test results. It is recommended that each medical laboratory establishes and reviews its own RIs. The use of direct methods is often unfeasible for most laboratories, while indirect methods are a more … Read more

Use of indirect methods and machine learning algorithms for the estimation of reference intervals, taking cortisol measurements as an exampleFatma Demet Arslanon October 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0984. Online ahead of print. ABSTRACT OBJECTIVES: This study aims to determine reliable reference intervals (RIs) for total cortisol (TC) in adults considering the effects of both age and blood collection time, using indirect methods and machine learning approaches. METHODS: Serum TC results from blood samples collected … Read more

Dental amalgams and blood mercury concentrations in American adultsDavid A Geieron October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0909. Online ahead of print. ABSTRACT OBJECTIVES: Dental amalgam (50 % mercury (Hg) by weight) is a commonly used material to restore a tooth damaged by decay. In recent years, amalgam safety has become a matter of ongoing controversy. This hypothesis-testing epidemiological study evaluated the relationship between … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human urineMyriam Otton October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0522. Online ahead of print. ABSTRACT OBJECTIVES: Precise and accurate determination of urinary cortisol is important for diagnosis and monitoring of cortisol excess and deficiency. To achieve this, a selective and specific, isotope-dilution two-dimensional heart-cut liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method was developed. METHODS: A novel, two-dimensional … Read more

Optimization and comparison of genomic DNA extraction from whole blood collected in PAXgene blood RNA tube using automated platformsJianlan Youon October 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1079. Online ahead of print. ABSTRACT OBJECTIVES: With the development of genomic technologies, the isolation of genomic DNA (gDNA) from clinical samples has become more important for both clinical diagnostics and research studies. Blood samples collected in PAXgene Blood RNA Tubes, which are typically used for RNA … Read more

An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid in human serum and plasmaTobias Schierscheron October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2024-0860. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid (MPA). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was utilized … Read more

ADORE: the performance characteristics of five automated platforms in the analysis of urinary dysmorphic erythrocytes and pathological castsJolien J Luimstraon October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0938. Online ahead of print. ABSTRACT OBJECTIVES: Automated urine particle analyzers are increasingly employed in clinical laboratories to standardize urinalysis. These systems can reduce workload, turnaround time and the inter-observer variation. This study aimed to assess the performance of five automated urine particle analyzers in detecting and … Read more

Automated reticulocyte counting: advances, standardization challenges, and clinical accessibilityHongyin Zhouon October 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1032. Online ahead of print. ABSTRACT With the advent of flow cytometry and dedicated fluorescent dyes in the 1980s, automated reticulocyte enumeration has effectively superseded conventional manual microscopy, dramatically boosting throughput and precision while, through metrics including the immature reticulocyte fraction (IRF) and reticulocyte production index (RPI), … Read more

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