Clinical Chemistry and Laboratory Medicine

Small-scale external quality assessment of methylated SHOX2 and RASSF1A detection in China: findings from 2023-2024Chengxiang Chuon October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-0846. Online ahead of print. ABSTRACT OBJECTIVES: DNA methylation in short homeobox gene 2 (SHOX2) and RAS association domain family protein 1 (RASSF1A) shows significant auxiliary diagnostic value for early-stage lung cancer. However, the detection accuracy is frequently compromised because of the complexity of the analytical procedures. … Read more

Development and validation of a machine learning model for accurate detection of wrong blood in tube errors in hospitalized patientsJordi Tortosa-Carrereson October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-0564. Online ahead of print. ABSTRACT OBJECTIVES: To develop and validate a machine-learning model based on routinely available biochemical and hematological parameters for detecting wrong blood in tube (WBIT) errors in hospitalized patients. METHODS: A retrospective multicenter study including one internal cohort (IC) and two external validation … Read more

Saliva sampling matters for salivary diagnostics of viral infectionsChuixi Kongon October 28, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 29. doi: 10.1515/cclm-2025-0607. Online ahead of print. ABSTRACT Saliva, a non-invasive biofluid with a variety of biomolecules, has been increasingly recognized as a reliable specimen in the diagnostics of viral infections. Compared to the standard specimens represented by blood and nasopharyngeal swab, saliva is advantageous in non-invasive, simple collection, … Read more

Point of care testing of biochemical markers for monitoring astronauts during long duration missions in deep spaceSimona Ferraroon October 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 28. doi: 10.1515/cclm-2025-0526. Online ahead of print. ABSTRACT BACKGROUND: Investigations into human performance and health status during long-duration spaceflights are ongoing aboard the International Space Station (ISS) and are critical for planning missions beyond Low Earth Orbit (LEO). This review evaluates the current evidence on point-of-care-testing (POCT) in space, … Read more

Methodological evaluation and clinical interpretation of hs-cTnI and hs-cTnT variations: a reappraisalAldo Clericoon October 27, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 28. doi: 10.1515/cclm-2025-1318. Online ahead of print. ABSTRACT Recent debates have focused on the impact of analytical imprecision in high-sensitivity cardiac troponin (hs-cTnI and hs-cTnT) assays on the diagnosis of non-ST-elevation myocardial infarction (NSTEMI), based on the absolute delta thresholds for the rapid rule-in/rule-out algorithms in emergency department (ED) … Read more

Hemolysis index. Can we uncritically trust manufacturer declarations?Alen Vrtaricon October 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-1302. Online ahead of print. ABSTRACT OBJECTIVES: Hemolysis is a common preanalytical interference in clinical biochemistry, affecting up to 3.3 % of routine samples and contributing to approximately 60 % of rejected specimens. It results from the release of intracellular constituents, such as hemoglobin and potassium, into … Read more

ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verificationGunnar Brandhorston October 22, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0637. Online ahead of print. ABSTRACT OBJECTIVES: Reference intervals (RIs) are essential for interpreting laboratory test results. It is recommended that each medical laboratory establishes and reviews its own RIs. The use of direct methods is often unfeasible for most laboratories, while indirect methods are a more … Read more

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