Clinical Chemistry and Laboratory Medicine

Interference of therapeutic monoclonal antibodies with electrophoresis and immunofixation of serum proteins: state of knowledge and systematic reviewSacha Pelletieron August 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 1. doi: 10.1515/cclm-2025-0678. Online ahead of print. ABSTRACT INTRODUCTION: The increasing use of therapeutic monoclonal antibodies (t-mAbs) has improved cancer and autoimmune disorder treatment. These therapeutics can interfere with serum protein electrophoresis (SPEP) and immunofixation (IF), potentially leading to the appearance of monoclonal bands that may be misinterpreted as … Read more

Fecal leukocyte esterase levels predict endoscopic severity as an alternative biomarker in inflammatory bowel diseaseFeng-Pai Tsaion August 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 1. doi: 10.1515/cclm-2025-0747. Online ahead of print. ABSTRACT OBJECTIVES: Our previous study revealed a correlation between fecal leukocyte esterase and fecal calprotectin levels. This study assessed the predictive value of fecal leukocyte esterase compared with fecal calprotectin and C-reactive protein of inflammatory bowel disease. METHODS: Patients with inflammatory bowel … Read more

Cerebrospinal fluid leptin in Alzheimer’s disease: relationship to plasma levels and to cerebrospinal amyloidElodie Bouaziz-Amaron August 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 1. doi: 10.1515/cclm-2025-0304. Online ahead of print. ABSTRACT OBJECTIVES: Dysregulation of brain leptin signaling contributes to Alzheimer’s disease (AD) pathophysiology, but plasma leptin may not accurately reflect central nervous system activity. This study examined the correlation between plasma and cerebrospinal fluid (CSF) leptin levels and their relationship with beta-amyloid … Read more

Failure Mode and Effects Analysis (FMEA) integrating quality indicators for risk assessment of the total testing process in human papillomavirus genotyping testing: a proactive risk analysis model for molecular diagnosticsTingting Lion August 29, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 29. doi: 10.1515/cclm-2025-0598. Online ahead of print. ABSTRACT OBJECTIVES: To develop a proactive risk assessment model for human papillomavirus (HPV) genotyping testing by integrating Failure Mode and Effects Analysis (FMEA) with quality indicators (QIs), ensuring compliance with ISO 15189:2022 and improving diagnostic accuracy. METHODS: A multidisciplinary team designed and … Read more

False-positive cardiac troponin I values due to macrotroponin in healthy athletes after COVID-19Angelika Hammerer-Lercheron August 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 17. doi: 10.1515/cclm-2025-0427. Online ahead of print. ABSTRACT OBJECTIVES: Cardiac troponins (cTn) are used to detect and quantify acute cardiomyocyte injury. In patients presenting with symptoms that could indicate myocarditis, elevated cTn concentrations typically mandate cardiac catheterization and heart muscle biopsy or cardiac magnetic resonance imaging (CMR). Accordingly, increased … Read more

Age distorts the interpretation of FIB-4Arne Åsbergon August 25, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 26. doi: 10.1515/cclm-2025-0615. Online ahead of print. ABSTRACT OBJECTIVES: To determine whether the diagnostic accuracy of the liver fibrosis marker FIB-4 and the likelihood ratios (LRs) of specific FIB-4 values vary with age. METHODS: We used a published dataset of 540 patients diagnosed with non-alcoholic fatty liver disease (NAFLD) … Read more

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