Clinical Chemistry and Laboratory Medicine

Reference ranges for ionized calcium in plasma in Danish children aged 0 days to 3 years using laboratory registry dataAnne-Sofie Allermann Faarvangon August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0353. Online ahead of print. ABSTRACT OBJECTIVES: Measurement of ionized calcium is frequently used in the assessment of calcium metabolism. However, the utility of ionized calcium in young children can pose a challenge. In this study, we aimed at establishing novel accurate reference ranges for ionized calcium … Read more

Assessment of measurement uncertainty of immunoassays and LC-MS/MS methods for serum 25-hydroxyvitamin DEtienne Cavalieron August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0554. Online ahead of print. ABSTRACT OBJECTIVES: Accurate 25-hydroxyvitamin D (25-(OH)D) assays are essential for defining vitamin D status and ensuring appropriate clinical decisions. Standardization efforts, including the Vitamin D Standardization Program (VDSP), aim to minimize assay variability. This study evaluates the measurement uncertainty (MU) of various … Read more

HCV serology: an unfinished agendaClaudio Gallion August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 11. doi: 10.1515/cclm-2025-0501. Online ahead of print. ABSTRACT Over 50 years have elapsed since the clinical definition of non-A, non-B hepatitis and 36 years since the unveiling of hepatitis C virus (HCV) and the availability of specific serological assays, but few advances in the serological diagnosis of HCV infection … Read more

Oral salt loading combined with postural stimulation tests for confirming and subtyping primary aldosteronismJenny Yeuk Ki Chengon August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0644. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is an underdiagnosed yet important condition. This study aimed to evaluate the diagnostic performance of a combined protocol using oral salt loading and postural stimulation tests (PST), named the balance study, to confirm and subtype PA. METHODS: … Read more

Clinical validation of a liquid chromatography single quadrupole mass spectrometry (LC-MS) method using Waters Kairos™ Amino Acid Kit reagentsRowan Hellieron August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0424. Online ahead of print. ABSTRACT OBJECTIVES: Quantitation of plasma amino acids (AA) is critical for the diagnosis and monitoring of inherited disorders of AA metabolism. AA analysis using ion-exchange chromatography (IEC) with post-column ninhydrin derivatization is time consuming, with run times of ∼2 h, limiting sample … Read more

A novel corrective model based on red blood cells indices and haemolysis index enables accurate unhaemolysed potassium determination in haemolysed samples – Hemokalc projectCharles R Lefèvreon August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0330. Online ahead of print. ABSTRACT OBJECTIVES: Haemolysis is a major preanalytical issue that affects potassium measurements, often leading to sample rejection and delayed clinical management. This study proposes a novel corrective model for accurate unhaemolysed potassium prediction. METHODS: Blood samples from 14 healthy volunteers were used … Read more

Total laboratory automation: fit for its intended purposes?Mario Plebanion August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0855. Online ahead of print. ABSTRACT Since the 1980s, automation has profoundly transformed clinical laboratory operations, enhancing efficiency, standardization, and throughput. This technological evolution has enabled laboratories to meet rising testing demands, address persistent workforce shortages, and control operational costs. Beyond analytical consolidation, significant progress has been … Read more

Establishment of region-, age- and sex-specific reference intervals for aldosterone and renin with sandwich chemiluminescence immunoassaysLin-Lin Caoon August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0587. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of plasma aldosterone (ALD) and renin is important in primary aldosteronism screening and diagnosis. The high variability of ALD and renin due to salt intake, age, and sex, as well as the lack of immunoassay standardization necessitates the … Read more

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