Clinical Chemistry and Laboratory Medicine

Analytical and diagnostic evaluation of the Anvajo fluidlab 2 analyzer: a novel urine particle analyzer for clinical application using digital holographic microscopy?Sigrid Deprezon January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 2. doi: 10.1515/cclm-2025-1202. Online ahead of print. ABSTRACT OBJECTIVES: The performance of a novel urine particle analyzer, fluidlab 2 (Anvajo GmbH, Dresden, Germany), was evaluated against phase-contrast visual microscopy according to the most recent EFLM European Urinalysis Guideline. METHODS: The fluidlab 2 device combines digital holographic microscopy with neural … Read more

Impact of pneumatic tube system transport and blood collection tubes on cell-free DNA analysis of plasma samplesLuisa Matos do Cantoon December 30, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Oct 9;64(2):332-342. doi: 10.1515/cclm-2025-0367. Print 2026 Jan 29. ABSTRACT OBJECTIVES: Transporting blood samples with pneumatic tube systems (PTSs) is routine in many hospitals. The influence of PTS transport on cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) analyses has not been comprehensively tested. METHODS: Paired blood samples from non-patient donors … Read more

Flow cytometry, cytology and histology in the diagnosis of ocular hematologic neoplasms: a 15-year monocentric experience with a focus on ocular lymphomasAlessandra Faldaon December 30, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Oct 9;64(2):489-504. doi: 10.1515/cclm-2025-0216. Print 2026 Jan 29. ABSTRACT OBJECTIVES: Ocular lymphomas are rare diseases that occur in ocular adnexa or specific intraocular regions. Although histology remains the gold standard, cytology and flow cytometry (FCM) are fundamental, mainly when a biopsy sampling is technically demanding. This study evaluated the effectiveness … Read more

Strategy of Laboratory Medicine – EFLM VisionMario Plebanion December 29, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 30. doi: 10.1515/cclm-2025-1678. Online ahead of print. ABSTRACT The strategic direction of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) is guided by global healthcare trends, rapid technological advancements, and the evolving role of laboratory professionals in modern medicine. The aim is to position laboratory medicine as … Read more

Kappa Index predicts disease activity and transition to high-efficacy therapies in multiple sclerosisSimone Marchesellion December 27, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 29. doi: 10.1515/cclm-2025-1339. Online ahead of print. ABSTRACT OBJECTIVES: The Kappa Index has proven its diagnostic value for multiple sclerosis (MS), while its prognostic potential remains to be fully explored. The objective of this study is thus to investigate the value of the Kappa Index at disease onset in … Read more

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