Clinical Chemistry and Laboratory Medicine

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17-hydroxyprogesterone in human serum and plasmaMartina Bachmannon March 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2025-1169. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of 17α-hydroxyprogesterone (17-OHP) in human serum and plasma is required for steroid profiling, to ensure the appropriate diagnosis of congenital adrenal hyperplasia. Therefore, an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) to quantify 17-OHP … Read more

Rare ANA patterns and their clinical correlates: a retrospective large-cohort studyRenren Ouyangon March 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2025-1493. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence and clinical associations of rare HEp 2 indirect immunofluorescence ANA patterns and to evaluate their relationships with disease categories, ANA titers, and expression form. METHODS: We retrospectively analyzed 366,524 ANA tests performed between 2018 and 2024 … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of linezolid in human serum and plasmaMarie Kubicovaon March 9, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 10. doi: 10.1515/cclm-2025-1366. Online ahead of print. ABSTRACT OBJECTIVES: The quantification of linezolid in serum and plasma matrices is crucial for therapeutic drug monitoring and pharmacokinetic studies. A reference measurement procedure (RMP) was developed and validated to provide accurate, precise, and reliable measurements, fit for its intended use while … Read more

Considerations and pragmatic strategies for implementation of point of care testing for high sensitivity cardiac troponin into the acute care settingPaul Collinsonon March 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2026-0210. Online ahead of print. ABSTRACT A challenge in the implementation of rapid risk-stratification algorithms for patients with suspected acute coronary syndrome is the turnaround time for cardiac troponin (cTn) from blood sampling to reporting of results. Measurement of cTn in whole blood using point of care … Read more

Discrepancies of results for post infusion levels of extended half-life factor VIII/IX concentrates – a cause of concern, awaiting for solutionArmando Tripodion March 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0042. Online ahead of print. ABSTRACT Hemophilia A and B are X-linked hemorrhagic disorders, characterized by low/dysfunctional factor (F)VIII or FIX, respectively. The history of hemophilia treatment has evolved remarkably over time from the introduction of cryoprecipitate in the 1960s to plasma-derived factors in the 1970s. The … Read more

Diagnostic performance evaluation of the Siemens Healthineers Atellica HEMA 580 hematology analyzer for abnormal cell detection and optimization of immature myeloid cell cut-offsVincenzo De Iuliison March 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Mar 3. doi: 10.1515/cclm-2026-0083. Online ahead of print. ABSTRACT OBJECTIVES: We evaluated the diagnostic performance of the Atellica HEMA 580 hematology analyzer for complete blood count (CBC) parameters compared with the ADVIA 2120i and assessed its capability to flag abnormal cells, and determined optimal cut-offs for immature myeloid cell detection. … Read more

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