Clinical Chemistry and Laboratory Medicine

Extended verification of an automated MALDI-TOF mass spectrometry system for high throughput serum M-protein measurementLouis Nevejanon December 2, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 3. doi: 10.1515/cclm-2025-0894. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to perform an extended analytical verification of the Immunoglobulin Isotypes (GAM) for the EXENT® Analyzer (EXENT®-GAM) assay, a MALDI-TOF mass spectrometry-based method for detecting and quantifying serum M-proteins in patients with plasma cell dyscrasias, and to compare … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of progesterone in human serum and plasmaSara Cheikh Ibrahimon December 1, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 1. doi: 10.1515/cclm-2025-0514. Online ahead of print. ABSTRACT OBJECTIVES: Progesterone regulates reproductive processes and is used clinically to monitor ovarian function in people experiencing fertility problems. Measuring serum progesterone is challenging as it is highly protein-bound and exists at very low physiological levels. An isotope dilution-liquid chromatography-tandem mass spectrometry-based … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone sulfate in human serum and plasmaSara Cheikh Ibrahimon November 29, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 1. doi: 10.1515/cclm-2025-0179. Online ahead of print. ABSTRACT OBJECTIVES: Dehydroepiandrosterone sulfate (DHEAS), the sulfate ester of dehydroepiandrosterone, is one of the most common steroid hormones in the human body and the precursor of several other androgens. It is primarily used as a diagnostic or prognostic indicator in adrenal and … Read more

From conventional to personalized reference intervals and decision limits: addressing latent errors in the post-post analytical phaseAbdurrahman Coskunon November 27, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 28. doi: 10.1515/cclm-2025-1338. Online ahead of print. ABSTRACT Laboratory errors are an important component of medical errors and are predominantly associated with the extra-analytical phases of the total testing process, particularly the pre-pre-analytical and post-post-analytical phases, which are largely dependent on clinical activities but also require laboratory support. The … Read more

Addressing the silent epidemic of recreational nitrous oxide use: a position, call to action and recommendations by the European Federation of Clinical Chemistry and Laboratory Medicine Committee on Biological Markers of Nitrous Oxide AbuseGuillaume Grzychon November 26, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 20. doi: 10.1515/cclm-2025-1060. Online ahead of print. ABSTRACT Recreational nitrous oxide (N2O) use has emerged as a growing public health concern, with increasing reports of neurological, psychiatric, and thrombotic complications. This position paper from the EFLM Committee on Biological Markers of Nitrous Oxide Abuse highlights the urgent need for … Read more

Performance evaluation of a new high-sensitivity cardiac troponin T assay: hs-cTnT (CLIA) assayXin Shuon November 25, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 26. doi: 10.1515/cclm-2025-1258. Online ahead of print. ABSTRACT OBJECTIVES: The Fourth Universal Definition of Myocardial Infarction recommends high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker for diagnosing myocardial infarction. This study evaluated the analytical and clinical performance of a novel hs-cTnT chemiluminescence immunoassay (CLIA) developed by Mindray. METHODS: Analytical … Read more

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