Clinical Chemistry and Laboratory Medicine

Introduction of new calibrator lots for quantitative protein mass spectrometry and adjustment of calibration settings for long term multiplex apolipoproteins quantificationNico P M Smiton July 8, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2025-0872. Online ahead of print. ABSTRACT OBJECTIVES: Calibration is a cornerstone of clinical chemistry test results and maintaining an in-house LDT requires periodic renewal of calibrators. Here we present the introduction of a new set of native human serum calibrators, using different curve fitting approaches for long-term … Read more

Detection of M-protein by iMS-IP and iMS-FLC assays redefines previously non-secretory POEMS syndromeYuan Huangon July 8, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0489. Online ahead of print. ABSTRACT OBJECTIVES: In polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, when monoclonal plasma cell proliferation is absent, it is considered ‘non-secretory POEMS syndrome’. We aimed to study whether M-protein was detectable by mass spectrometry (MS) in previously non-secretory POEMS syndrome. … Read more

A revised approach to data modelling for patient classification to determine analytical performance specifications based on Milan 1bGraham Ross Dallas Joneson July 8, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2026-0444. Online ahead of print. ABSTRACT A widely accepted approach to setting Analytical Performance Specifications (APS) in laboratory medicine is the Milan models. The Milan Model 1b is an approach in which APS are developed based on patient classification or clinical decision-making, noting that these factors are … Read more

Assessing neonatal and paediatric acute kidney injury: current practices and insights from the IFCC C-ETPLM International Laboratory SurveyTim Langon July 8, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2026-0626. Online ahead of print. ABSTRACT OBJECTIVES: Identification of acute kidney injury (AKI) in neonatology and paediatrics continues to present challenges to laboratories. Emerging biomarkers are being developed which may offer early detection but haven’t been adopted in current guidelines yet. The aim of this IFCC survey … Read more

A novel comprehensive non-invasive prenatal testing system for the simultaneous detection of single-gene disorders, chromosomal structural rearrangements, and aneuploidyYichen Zhangon July 8, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2025-1488. Online ahead of print. ABSTRACT OBJECTIVES: Invasive prenatal diagnosis is recommended for high-risk pregnancies, but many decline due to potential complications. To date, no non-invasive prenatal testing (NIPT) simultaneously detects monogenic diseases, balanced chromosomal rearrangements (BCRs), and aneuploidies. We developed a comprehensive NIPT to detect monogenic … Read more

Fish-shaped erythrocytes and pincer cells co-occur in distinct hematological disorders and are associated with anemia severityAnna Lena Lembeckon July 6, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 7. doi: 10.1515/cclm-2026-0957. Online ahead of print. ABSTRACT OBJECTIVES: Red blood cell (RBC) morphology in peripheral blood smears (PBS) remains essential for the differential diagnosis of anemia and other hematologic disorders. As yet unclassified poikilocytes, fish-shaped RBCs and pincer (mushroom-shaped) cells are rarely observed but have been described as … Read more

Artificial general intelligence and the clinical laboratory: a paradigm shift toward Lab 2.0Koichiro Yujion July 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0789. Online ahead of print. ABSTRACT Clinical laboratory medicine faces converging structural pressures: workforce shortages, growing data complexity, and rapid advances in artificial intelligence (AI). Some prominent developers, including Demis Hassabis of Google DeepMind, have projected the arrival of artificial general intelligence (AGI) around 2030; such timelines … Read more

Addressing property and unit discordance in laboratory interoperability: the role of NPU as a governance layerKuenyoul Parkon July 4, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0743. Online ahead of print. ABSTRACT OBJECTIVES: Unified Code for Units of Measure (UCUM) encodes syntax without prescribing which unit should be used. The Nomenclature for Properties and Units (NPU) terminology, developed by IFCC and IUPAC, specifies both the kind-of-quantity (e.g., mass concentration or substance concentration) and … Read more

Ethical evaluation of reflex and reflective testing in conformity with ISO 15189:2022 at the value-based laboratory medicine eraGulsen Yilmazon July 3, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 6. doi: 10.1515/cclm-2026-0661. Online ahead of print. ABSTRACT OBJECTIVES: The objective of this study is to evaluate the ethical dimensions of reflex and reflective testing (RRT) within the framework of value-based laboratory medicine and in alignment with ISO 15189:2022. The study aims to highlight the challenges in guiding and … Read more

Emerging blood-based diagnostic strategies for tuberculosisChunlin Yueon July 1, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 2. doi: 10.1515/cclm-2026-0123. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a global public health challenge. Rapid and accurate diagnostic methods are critical for effective TB control. In recent years, serological diagnosis has attracted growing attention with the continuous identification of novel biomarkers, owing … Read more

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