Clinical Chemistry and Laboratory Medicine

Pseudovirus reference material and RT-digital PCR reference method for the quantification of human rhinovirus RNA with metrological traceabilityHuijie Lion May 6, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 7. doi: 10.1515/cclm-2025-1137. Online ahead of print. ABSTRACT OBJECTIVES: This study developed a pseudoviral human rhinovirus (HRV) reference material using pseudovirus technology and integrating RT-dPCR with HPLC-IDMS to achieve accurate HRV RNA quantification, aiming to standardize HRV detection across labs and platforms. METHODS: We developed an RT-digital PCR (RT-dPCR) … Read more

EFLM position statement on the proposed 2025/0404(COD) IVDR Amendment of Article 5.5Christa Cobbaerton May 6, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 7. doi: 10.1515/cclm-2026-0580. Online ahead of print. ABSTRACT Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR) was introduced to enhance patient safety and ensure the availability of safe and effective diagnostics across the European Union. However, its implementation has led to substantial unintended consequences, including certification bottlenecks, … Read more

From research to reality: real-world effectiveness of point-of-care testing in the emergency departmentSalomón Martin-Pérezon May 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 6. doi: 10.1515/cclm-2026-0289. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the real-world impact of Point-of-Care Testing on care timeliness and patient flow in the emergency department. METHODS: A before-and-after, matched-cohort study was conducted involving 25,291 patients with Emergency Severity Index levels 3-4. A POCT group (n=8,746) was compared … Read more

Capillary dried blood microsampling is not suited for dihydropyrimidine dehydrogenase (DPD) phenotypingKevin Vandenbrouckeon May 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 6. doi: 10.1515/cclm-2026-0146. Online ahead of print. ABSTRACT OBJECTIVES: Dihydropyrimidine dehydrogenase (DPD) phenotyping through uracil and dihydrouracil determination is a well-established approach to identify (partial) DPD deficiencies prior to fluoropyrimidine chemotherapy. However, preanalytical stability has challenged this test for years. This study therefore investigated whether dried blood spots (DBS) … Read more

Essential laboratory tests in emergencies; on behalf of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Committee on Preparation of Laboratories for Emergencies (C-PLE)Giuseppe Lippion May 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 6. doi: 10.1515/cclm-2026-0577. Online ahead of print. ABSTRACT This article aims to define a minimum panel of essential laboratory tests to be used in emergency and disaster settings through expert consensus. A structured survey was distributed to the 24 members of the European Federation of Clinical Chemistry and Laboratory … Read more

Clinical validation and implementation of mSTOP, a machine learning-based, longitudinal prediction model for the early identification of non-small cell lung cancer patients who not benefit from immune checkpoint inhibitor treatmentHuub H van Rossumon April 29, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2025-1624. Online ahead of print. ABSTRACT OBJECTIVES: There has been a lot of interest in the field of laboratory medicine regarding the use of machine learning (ML)-based prediction models. The longitudinal ML-based Serum Tumor marker-based Outcome Prediction (STOP) model was previously developed to identify non-small cell lung … Read more

Reply to “Biological variation of serum cholinesterase activity in healthy subjects”: analytical validation of cholinesterase activity measurement in routine practice: experience from a French clinical laboratoryPierre Mercieron April 29, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 29. doi: 10.1515/cclm-2026-0465. Online ahead of print. NO ABSTRACT PMID:42053521 | DOI:10.1515/cclm-2026-0465

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