Clinical Chemistry and Laboratory Medicine

The complete blood count: data or clinical information?Mario Plebanion May 12, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 13. doi: 10.1515/cclm-2026-0590. Online ahead of print. ABSTRACT Harmonization in laboratory medicine is increasingly recognized as a fundamental requirement to ensure interchangeable laboratory information, avoid confusion among users, and ultimately improve patient safety. However, current evidence continues to highlight substantial gaps in harmonization across several dimensions of the total … Read more

A model to increase automation and support reliable interpretation of clinical chemistry testsAlessandra Faldaon May 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 11. doi: 10.1515/cclm-2025-1727. Online ahead of print. ABSTRACT OBJECTIVES: Pathological conditions may result in clinical chemical values exceeding the linearity range of laboratory methods. In clinical practice, not all tests require exact numerical values for patient management, as useful information can still be provided when results are reported to … Read more

Limitations to the development of Milan model 1b analytical performance specificationsGraham Ross Dallas Joneson May 9, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 11. doi: 10.1515/cclm-2026-0377. Online ahead of print. ABSTRACT A widely accepted approach to setting Analytical Performance Specifications (APS) in laboratory medicine is the Milan models. Milan model 1b is an approach where APS are developed based on patient classification, or clinical decision-making, noting that these factors link to the … Read more

Factors associated with analytical errors in blood chemistry testsHyunjung Kimon May 9, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 11. doi: 10.1515/cclm-2026-0153. Online ahead of print. ABSTRACT OBJECTIVES: Few studies have systematically evaluated the factors contributing to laboratory errors in the analytical phase. This study analyzed five years of retest data to determine the frequency and characteristics of analytical errors across routine blood chemistry parameters, identify analytes most … Read more

Analytical agreement and platform-specific decision thresholds for plasma p-tau217 measured on Lumipulse G600II and Cobas e801 in a paired CSF-plasma cohortMaría Martínez-Bujidoson May 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 5. doi: 10.1515/cclm-2026-0395. Online ahead of print. ABSTRACT OBJECTIVES: Plasma phosphorylated tau at threonine 217 (p-tau217) has emerged as a highly accurate blood-based biomarker of Alzheimer’s disease (AD) pathology. As disease-modifying anti-amyloid therapies enter clinical practice, scalable biomarkers with robust and clinically interpretable decision thresholds are required. However, evidence … Read more

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