Clinical Chemistry and Laboratory Medicine

Long-read Oxford Nanopore sequencing enables rapid, cost-effective, and comprehensive TTR genetic testing for hereditary transthyretin amyloidosisGilles Millaton May 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 20. doi: 10.1515/cclm-2026-0553. Online ahead of print. ABSTRACT OBJECTIVES: Hereditary transthyretin amyloidosis (ATTRv) is a rare autosomal dominant disorder caused by pathogenic variants in the TTR gene, with marked clinical heterogeneity and frequent underdiagnosis. Genetic confirmation is essential for patient management but is traditionally based on Sanger sequencing or … Read more

Quantitative analysis and clinical evaluation of 20- and 22-kDa growth hormone isoforms in somatotroph adenoma using immunocapture coupled with LC-MS/MSYao Huon May 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 19. doi: 10.1515/cclm-2026-0382. Online ahead of print. ABSTRACT OBJECTIVES: The 20- and 22-kDa isoforms of growth hormone 1 (GH1) play potentially distinct physiological and pathological roles, but their structural similarity makes quantification challenging. Conventional immunoassays lack sufficient specificity, highlighting the need for more precise analytical methods. METHODS: We developed … Read more

EurA1c: a review of 9 years performance of up to 5120 laboratories in 29 country and 26 manufacturer groups according to current and proposed criteria of the IFCC Model for Quality Targets in relation to the use of HbA1c for monitoring and diagnosis of diabetesEurA1c Trial Groupon May 18, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 19. doi: 10.1515/cclm-2026-0276. Online ahead of print. ABSTRACT OBJECTIVES: A major objective of the IFCC Committee for Education in the Use of Biomarkers in Diabetes is to monitor the success of global standardization of HbA1c through benchmark evaluation of the performance by country and manufacturer. METHODS: From 2016 to … Read more

Comprehensive assessment of innovative immunoassays for the detection of myositis specific antibodiesIvo Rimann-Langejuergenon May 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 15. doi: 10.1515/cclm-2026-0179. Online ahead of print. ABSTRACT OBJECTIVES: Myositis specific antibodies (MSA) are important in the diagnosis of idiopathic inflammatory myopathies (IIM). In addition, several studies have shown clear utility to stratify IIM patients into more homogeneous subsets based on MSA signatures. However, methods for MSA detection show … Read more

Combined measurement uncertainty of HbA1c and glucose using ISO 20914:2019 and outcome-based simulationEmine Feyza Yurton May 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 15. doi: 10.1515/cclm-2026-0388. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to calculate the measurement uncertainty (MU) of HbA1c and glucose according to ISO/TS 20914:2019 guideline and to evaluate using indirect outcome-based analytical performance specifications (APS). METHODS: MU was estimated using internal quality control data collected between October … Read more

Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practiceHanna De Baetson May 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 14. doi: 10.1515/cclm-2026-0320. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of tacrolimus is essential due to its high inter- and intra-patient variability and narrow therapeutic window. Conventional venous blood sampling may limit sampling frequency and patient convenience. Capillary dried blood spot (DBS) sampling represents a patient-centric … Read more

Optimising newborn screening for galactosaemia: reclassifying GALE and GALM deficiencies as non-target conditions to improve specificityDoris Wongon May 13, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 14. doi: 10.1515/cclm-2026-0419. Online ahead of print. ABSTRACT OBJECTIVES: Traditionally, neonates were screened for classical galactosaemia in 4 of the 5 jurisdictions in Australia creating inequitable access to early intervention. A push to nationally harmonise newborn bloodspot screening enabled the state of Victoria to proceed with implementation of screening … Read more

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