Clinical Chemistry and Laboratory Medicine

Choosing Wisely – avoiding medical overuse: evidence assessment of recommendations on laboratory parametersCihan Berion July 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0358. Online ahead of print. ABSTRACT OBJECTIVES: Launched in 2012, the Choosing Wisely initiative promotes evidence-based recommendations to reduce unnecessary tests and treatments. This study reviewed laboratory-related recommendations from five countries (USA, UK, Germany, Switzerland, and Austria) to assess their scientific validity. METHODS: Choosing Wisely websites were … Read more

Predictive value of serum biomarkers for first trimester prediction of preterm prelabour rupture of membranes (PPROM): a systematic review and meta-analysisMarion Rouzaireon July 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0380. Online ahead of print. ABSTRACT INTRODUCTION: The identification of early biomarkers is a critical prerequisite for the development and optimization of preventive strategies targeting preterm prelabour rupture of membranes (pPROM). The aim of this systematic review was to evaluate first trimester serum biomarkers for predicting the … Read more

Prospective real-time implementation and verification of patient-based real-time quality control using average of normals in a tertiary hospital laboratorySe-Eun Kooon July 16, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0201. Online ahead of print. ABSTRACT OBJECTIVES: Practical implementation of patient-based real-time quality control (PBRTQC) requires analyte- and institution-specific optimization. This study evaluated the operational feasibility of average-of-normals (AoN)-based PBRTQC through a structured selection process and prospective event-based validation. METHODS: PBRTQC monitoring was performed using the Average … Read more

Establishment of DBS-based reference intervals for vitamins, essential elements, and potentially toxic elements in Chinese adults from Hubei ProvinceMengtong Yangon July 15, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0511. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to establish a comprehensive panel of dried blood spot (DBS)-specific reference intervals (RIs) for vitamins, essential elements, and potentially toxic elements (PTEs) in Chinese adults, and to introduce a hierarchical decision framework for selecting between healthy- and … Read more

Venous-capillary blood agreement for routine chemistry analytes: effects of collection site and sample matrixSara Dezaon July 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 15. doi: 10.1515/cclm-2026-0671. Online ahead of print. ABSTRACT OBJECTIVES: Capillary blood sampling enables minimally invasive testing and decentralized workflows, but interchangeability with venous specimens may depend on collection site, device, and matrix. METHODS: We conducted a single-center, paired clinical study of 480 adults yielding 960 capillary specimens (fingertip lancet … Read more

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