Clinical Chemistry and Laboratory Medicine

Diagnostic accuracy of TIMP-2 and IGFBP7 for detecting acute kidney injury in adult intensive care unit patients: a systematic review and meta-analysisThais F Comizon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0234. Online ahead of print. ABSTRACT Acute kidney injury (AKI) is a frequent complication in hospitalized patients, particularly those admitted to the intensive care unit (ICU), which leads to high rates of morbidity and mortality. Under these conditions, tissue inhibitor metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein … Read more

Unity among the units – a position paper by the DGKLRalf Junkeron March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 18. doi: 10.1515/cclm-2026-0075. Online ahead of print. ABSTRACT More than 30 years after German reunification, the units of measurement used for laboratory medical parameters still differ between eastern and western Germany. While the eastern German states predominantly use “SI” units, “conventional” units are common in medical facilities in the … Read more

S100B urine levels are gestational age, birthweight, delivery mode and gender-dependent in healthy newbornsEbe D’Adamoon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2025-1526. Online ahead of print. ABSTRACT OBJECTIVES: The inclusion of neurobiomarkers (NB) into routine clinical practice remains an unresolved challenge. Among the actions recommended by leading international institutions, a key priority is the establishment of reference curves during the perinatal period. The aim of the study was … Read more

Establishing the laboratory error database: rationale, methodology, and a practical exampleHikmet Can Çubukçuon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0174. Online ahead of print. ABSTRACT Laboratory errors represent a critical yet underestimated threat to patient safety, with 26-30 % of reported errors adversely affecting patient care. Despite extensive scientific literature, no sustainable, open-access platform exists that allows laboratory professionals to rapidly access comprehensive information on error … Read more

Serum protein electrophoresis pattern associated with elevated polyclonal IgG4 concentrations: a monoclonal-mimicking profile with potentially significant clinical implicationsLaura Michettion March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0183. Online ahead of print. ABSTRACT OBJECTIVES: To estimate the frequency and characterize the distinctive features of the serum electrophoretic pattern associated with polyclonal elevations of IgG4, and to evaluate its clinical relevance. METHODS: A total of 127,827 serum protein electrophoresis (SPEP) analyses performed in our laboratory … Read more

Representation and performance of CE-marked and in-house in vitro diagnostic tests for routine laboratory parameters in external quality assessment programmesChristoph Buchtaon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 17. doi: 10.1515/cclm-2026-0288. Online ahead of print. ABSTRACT OBJECTIVES: European legislation requires detailed performance evaluation of in vitro diagnostic medical devices (IVD-MD) by both commercial manufacturers (through the Conformité Européenne (CE) mark) and in-house (IH) IVDs. Little information is currently available on how CE- and IH-IVDs are mapped in … Read more

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